Abstract:
:N-Deacetylcolchiceine (DAC) administered i.p. to rats decreased the level of serum cholesterol and apoB. It was accompanied by the fall of HDL-C due to the decrease of both HDL subfractions HDLa and HDLb, and by a rather weaker decrease of LDL-C. The levels of serum and lipoprotein triacylglycerols were not significantly affected. The "clearing reaction" to heparin in DAC rats differed from controls with regard to plasma cholesterol resulting in its accumulation in HDLa and LDL simultaneously with an increased activity of post-heparin lipoprotein lipase. These results suggest that the DAC accelerates the lipoprotein cholesterol metabolism.
journal_name
Planta Medjournal_title
Planta medicaauthors
Skottová N,Vecera R,Walterová D,Simánek Vsubject
Has Abstractpub_date
1992-02-01 00:00:00pages
26-30issue
1eissn
0032-0943issn
1439-0221journal_volume
58pub_type
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