The effect of N-deacetylcolchiceine on serum lipoproteins in rats.

Abstract:

:N-Deacetylcolchiceine (DAC) administered i.p. to rats decreased the level of serum cholesterol and apoB. It was accompanied by the fall of HDL-C due to the decrease of both HDL subfractions HDLa and HDLb, and by a rather weaker decrease of LDL-C. The levels of serum and lipoprotein triacylglycerols were not significantly affected. The "clearing reaction" to heparin in DAC rats differed from controls with regard to plasma cholesterol resulting in its accumulation in HDLa and LDL simultaneously with an increased activity of post-heparin lipoprotein lipase. These results suggest that the DAC accelerates the lipoprotein cholesterol metabolism.

journal_name

Planta Med

journal_title

Planta medica

authors

Skottová N,Vecera R,Walterová D,Simánek V

subject

Has Abstract

pub_date

1992-02-01 00:00:00

pages

26-30

issue

1

eissn

0032-0943

issn

1439-0221

journal_volume

58

pub_type

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