Abstract:
:The active ingredient dl-tetrahydropalmatine (THP) isolated from the traditional Chinese herb Corydalis racemosa has been found to have antihypertensive effects. However, severe cardiac and neurological toxic effects were reported from using this herb for the treatment of pain. In an isolated perfused rat heart model, THP at the concentration of 100 microM was found to have a negative effect (-45%) on left ventricular pressure and this effect was produced concentration-dependently from concentrations lower than 50 microM. In isolated cardiomyocytes, radioactive calcium influx was also inhibited significantly by THP at the concentration of 100 microM and this effect was also in a concentration-dependent manner (-39%). In a patient with latent heart disease, the use of Corydalis should probably be detrimental, the toxic effect was probably due to calcium influx inhibition.
journal_name
Planta Medjournal_title
Planta medicaauthors
Chan P,Chiu WT,Chen YJ,Wu PJ,Cheng JTdoi
10.1055/s-1999-13998subject
Has Abstractpub_date
1999-05-01 00:00:00pages
340-2issue
4eissn
0032-0943issn
1439-0221journal_volume
65pub_type
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