Ganoderic acids from Ganoderma lucidum: inhibitory activity of osteoclastic differentiation and structural criteria.

Abstract:

:Increased osteoclastic bone resorption plays a central role in the pathogenesis of many bone diseases. Ganoderma lucidum is known for medicinal effects such as anti-inflammatory and anti-bone resorption activities. In this study, we investigated the inhibitory effects of ganoderic acids isolated from G. lucidum on osteoclastic differentiation using RAW264 cells in vitro. A carbonyl in C7 is essential to elicit the inhibition of osteoclast differentiation.

journal_name

Planta Med

journal_title

Planta medica

authors

Liu J,Shiono J,Shimizu K,Kondo R

doi

10.1055/s-0029-1186035

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

137-9

issue

2

eissn

0032-0943

issn

1439-0221

journal_volume

76

pub_type

信件
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