Assessment of antimycobacterial activity of a series of mainly marine derived natural products.

abstract：:The inhibitory action of the major constituent of Sebastiania schottiana (Euphorbiaceae), 2-hydroxy-4,6-dimethoxyacetophenone (xanthoxyline) on contractions induced by agonists and electrical stimulation of smooth and cardiac muscle preparations was analysed. Xanthoxyline (30 to 300 microM) inhibited contractions of t...

journal_title：Planta medica

authors： Calixto JB,Miguel OG,Yunes RA,Rae GA

更新日期：1990-02-01 00:00:00

abstract：:The chloroform extract of Valeriana officinalis led to the isolation of clionasterol-3-O-beta-D-glucopyranoside and a mixture of 6'-O-acyl-beta-D-glucosyl-clionasterols. The acyl moieties were identified as hexadecanoyl, 8 E,11 E-octadecadienoyl and 14-methylpentadecanoyl by alkaline hydrolysis followed by GC-MS analy...

journal_title：Planta medica

authors： Pullela SV,Choi YW,Khan SI,Khan IA

更新日期：2005-10-01 00:00:00

abstract：:DNA technology provides a powerful tool to complement chemical analyses for authentication of Chinese medicinal plants and to ensure that herbal materials are not contaminated with ineffective or potentially harmful substitutes or adulterants. In the last two decades molecular biotechnology has provided sophisticated ...

journal_title：Planta medica

authors： Heubl G

更新日期：2010-12-01 00:00:00

abstract：:Flavonoids are metabolized in vivo to monocyclic phenolic acids. We investigated whether 18 phenolic acids of the benzoic, phenylacetic, phenylpropanoic or cinnamic series-known or potential metabolites of flavonoids-inhibit reactive oxygen species (ROS) released by human polymorphonuclear neutrophils (PMNs). Chemilum...

journal_title：Planta medica

authors： Limasset B,Ojasoo T,le Doucen C,Doré JC

更新日期：1999-02-01 00:00:00

abstract：:The essential oil obtained from the aerial parts of Phlomis lanata has been analyzed by GC/MS. 48 compounds representing 96.85% of the oil were identified; alpha-pinene, limonene and trans-caryophyllene were found as its main components. The essential all showed a moderate in vitro activity against six Gram (+/-) bact...

journal_title：Planta medica

authors： Couladis M,Tanimanidis A,Tzakou O,Chinou IB,Harvala C

更新日期：2000-10-01 00:00:00

abstract：:The content of ursolic acid and oleanolic acid was determined in different plant parts of two Glechoma species, G. hederacea and G. hirsuta. To achieve optimal extraction conditions of ursolic acid and oleanolic acid from plant material, several methods including maceration, heat reflux, Soxhlet, and ultrasonic extrac...

journal_title：Planta medica

authors： Grabowska K,Żmudzki P,Wróbel-Biedrawa D,Podolak I

更新日期：2021-01-15 00:00:00

abstract：:Ten alkaloids were isolated from the bulb of CORYDALIS HSUCHOWENSIS W. Y. Lian nov. ined. Among them nine alkaloids are known, identified as (-)-stylopine ( 1), cheilanthifoline ( 2), (+)-adlumidine ( 3), (+)-bicuculline ( 4), sibiricine ( 5), humosine A ( 6), (+)-bulbocapnine ( 7), (-)-scoulerine ( 8), and protopine ...

journal_title：Planta medica

authors： Zhou JY,Tong XJ,Lian WY,Fang QC

更新日期：1991-04-01 00:00:00

abstract：:Twelve phenolic compounds, including three stilbenes, two flavonoids, two coumarins, one neolignan, and four lignans, isolated from Euphorbia and Pycnanthus species or obtained by derivatization, were assayed for their potential antineoplastic efficacy in three human cancer cell lines: gastric (EPG85-257), pancreatic ...

journal_title：Planta medica

authors： Duarte N,Lage H,Abrantes M,Ferreira MJ

更新日期：2010-07-01 00:00:00

abstract：:For quantitative determination of grayanotoxin I (1) in plant material, a GC/MS method was developed after trimethylsilyl derivatisation of the analytes. Forskolin (5) was used as an internal standard for quantification. ICH-compliant method validation indicated sufficient specificity, precision, quantitation (15 µg/m...

journal_title：Planta medica

authors： Lechtenberg M,Dierks F,Sendker J,Louis A,Schepker H,Hensel A

更新日期：2014-10-01 00:00:00

abstract：:Solasodine--a steroid present in the mucilaginous exotesta of the seed in Solanum viarum Dunal (syn. S. khasianum var. chatterjeeanum) is a major source of steroidal raw material. Evidence for the site of solasodine synthesis was sought through reciprocal grafts involving steroid-bearing S. viarum (both diploid and au...

journal_title：Planta medica

authors： Srinivas M,Krishnan R

更新日期：1996-08-01 00:00:00

abstract：:The anti-inflammatory effects of boldine and reticuline isolated from Litsea cubeba were evaluated by using xylene-induced ear edema and carrageenan-induced paw edema in mice and rats. Our results demonstrated that intragastric administration with boldine and reticuline significantly mitigated ear weight in mice and d...

journal_title：Planta medica

authors： Yang X,Gao X,Cao Y,Guo Q,Li S,Zhu Z,Zhao Y,Tu P,Chai X

更新日期：2018-01-01 00:00:00

abstract：:Sesquiterpene lactones 1-5 were isolated for the first time from the ethyl acetate of Vernonia fastigiata (Asteraceae). Compounds 3, 4 and 5 are new, compounds 1 and 2 have been found earlier in other Vernonia species but not in V. fastigiata. ...

journal_title：Planta medica

authors： Roos G,Prawat H,Walter CU,Klaiber I,Vogler B,Guse JH,Kraus W

更新日期：1998-10-01 00:00:00

abstract：:Three new vermistatin derivatives, 6-demethylpenisimplicissin (1), 5'-hydroxypenisimplicissin (2), and 2''-epihydroxydihydrovermistatin (3), along with five known vermistatin analogues, methoxyvermistatin (4), vermistatin (5), 6-demethylvermistatin (6), hydroxyvermistatin (7), and penisimplicissin (8), were isolated f...

journal_title：Planta medica

authors： Liu Y,Xia G,Li H,Ma L,Ding B,Lu Y,He L,Xia X,She Z

更新日期：2014-07-01 00:00:00

abstract：:During the screening of antimalarial substances, the 80% EtOH extract from the outer bark of Ochna integerrima Merr. (Ochnaceae) was shown to have a good anti-malarial activity (IC50 value: 6.5 microg/mL) whereas extracts from the inner barks of O.integerrima showed no antimalarial activity. Biflavanone (1), which had...

journal_title：Planta medica

authors： Ichino C,Kiyohara H,Soonthornchareonnon N,Chuakul W,Ishiyama A,Sekiguchi H,Namatame M,Otoguro K,Omura S,Yamada H

更新日期：2006-06-01 00:00:00

abstract：:Eight compounds were isolated from the CH (2)Cl (2) extracts of ERYTHRINA SENEGALENSIS to assess HIV-1 protease (PR) activity inhibition. The prenylated isoflavone structures, identified by spectroscopic analysis, were 8-prenylluteone ( 1), auriculatin ( 2), erysenegalensein O ( 3), erysenegalensein D ( 4), erysenegal...

journal_title：Planta medica

authors： Lee J,Oh WK,Ahn JS,Kim YH,Mbafor JT,Wandji J,Fomum ZT

更新日期：2009-02-01 00:00:00

abstract：:The phenylpropanoid dibenzylbutyrolactone lignan arctigenin, a key component found in Arctium lappa, or burdock, has been reported with a variety of therapeutic effects including anticancer, anti-inflammation, and antivirus effects. Using LC/MS/MS, three novel metabolites of arctigenin, namely, arctigenic acid, arctig...

journal_title：Planta medica

authors： Gao Q,Zhang Y,Wo S,Zuo Z

更新日期：2013-04-01 00:00:00

abstract：:From the defatted seeds of Cassia marginata fam (Caesalpinaceae) two new anthraquinone glycosides have been isolated and characterised as physcion-8-O-alpha-L-xylopyranoside and emodin-8-O-alpha-L-arabinopyranoside. ...

journal_title：Planta medica

authors： Duggal JK,Misra K

更新日期：1982-05-01 00:00:00

abstract：:During the seasons 1989-1993, Valeriana officinalis plants were investigated for their contents of essential oil, valerenic acid and derivatives, and valepotriates. Harvesting of the subterranean parts was started in August of the year in which the seeds were sown, and continued until the last week of April of the sub...

journal_title：Planta medica

authors： Bos R,Woerdenbag HJ,van Putten FM,Hendriks H,Scheffer JJ

更新日期：1998-03-01 00:00:00

abstract：:A micellar electrokinetic capillary chromatography (MEKC) method for the determination of xanthyletin and xanthoxyletin in the roots bark of three Citrus plants was developed for the first time. The electrophoresis buffer was 10 mmol/L sodium borate containing 50 mmol/L sodium dodecyl sulfate, 20% (v/v) acetonitrile a...

journal_title：Planta medica

authors： Wang SF,Ju Y,Chen XG,Hu ZD

更新日期：2003-05-01 00:00:00

abstract：:In our ongoing efforts to identify effective naturally sourced agents for the treating of diabetic complications, two new (1 and 2) and 11 known phenolic compounds (3-13) were isolated from an 80 % ethanol extract of Litsea japonica leaves. The structures of the new compounds were established by spectroscopic and chem...

journal_title：Planta medica

authors： Lee IS,Kim YJ,Jung SH,Kim JH,Kim JS

更新日期：2017-02-01 00:00:00

abstract：:Bioassay-guided fractionation of the H(2)O extract of the seeds of Psoralea corylifolia furnished one hepatoprotective compound, bakuchiol (1), together with two moderately active compounds, bakuchicin (2) and psoralen (3), on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC(50) values of compo...

journal_title：Planta medica

authors： Cho H,Jun JY,Song EK,Kang KH,Baek HY,Ko YS,Kim YC

更新日期：2001-11-01 00:00:00

abstract：:Malaria is a parasitic disease endemic to tropical and subtropical regions responsible for hundreds of millions of clinical cases and hundreds of thousands of deaths yearly. Its agent, the Plasmodium sp., has a highly variable antigenicity, which accounts for the emergence and spread of resistance to all available tre...

journal_title：Planta medica

authors： Mamede L,Ledoux A,Jansen O,Frédérich M

更新日期：2020-06-01 00:00:00

abstract：:A crude polysaccharide fraction (DAP-1) was prepared from roots of Dipsacus asperoides by hot water extraction and EtOH precipitation, and tested for anti-complementary activity, mitogenic activity of lymphocytes, and effects on acid phosphatase and phagocytic activities of macrophages. DAP-1 showed not only anti-comp...

journal_title：Planta medica

authors： Zhang Y,Kiyohara H,Matsumoto T,Yamada H

更新日期：1997-10-01 00:00:00

abstract：:Casearin X (CAS X) is the major clerodane diterpene isolated from the leaves of Casearia sylvestris and has been extensively studied due to its powerful cytotoxic activity at low concentrations. Promising results for in vivo antitumor action have also been described when CAS X was administered intraperitoneally in mic...

journal_title：Planta medica

authors： Moreira da Silva R,de Gaitani CM,Marques LMM,Fraige Baraco K,Cavalheiro AJ,de Moraes LAB,Lopes NP,de Oliveira ARM

更新日期：2019-03-01 00:00:00

abstract：:Using exhaustive chromatographic separation we have isolated (-)-tigloyl-deangeloyl-gomisin F as a novel dibenzocyclooctadiene lignan from schisandra chinensis. With the help of HPLC, we further isolated (+)-schisandrin, (+)-deoxyschisandrin, (+)-γ-schisandrin, (-)-gomisin J, (+)-gomisin A, (-)-gomisin N, (-)-tigloyl-...

journal_title：Planta medica

authors： Smejkal K,Slapetová T,Krmenčík P,Babula P,Dall'Acqua S,Innocenti G,Vančo J,Casarin E,Carrara M,Kalvarová K,Dvorská M,Slanina J,Kramářová E,Julínek O,Urbanová M

更新日期：2010-10-01 00:00:00

abstract：:From Polygonum hydropiper L., a C13-norisoprenoid glucoside was isolated and its absolute configuration was established to be (6S,9S)-roseoside (1) by spectroscopic evidence and X-ray crystallographic analysis of its acetate derivative (2). In addition, the stereostructure of roseoside from Canthium subcordatum was re...

journal_title：Planta medica

authors： Murai Y,Kashimura S,Tamezawa S,Hashimoto T,Takaoka S,Asakawa Y,Kiguchi K,Murai F,Tagawa M

更新日期：2001-07-01 00:00:00

abstract：:Juniperus excelsa fruit essential oil as well as J. oxycedrus, Cedrus libani, and Pinus pinea wood essential oils have been obtained with yields between 2.2 ± 0.3 % to 3.4 ± 0.5 % and analyzed by gas chromatography. Sesquiterpenes mainly characterized C. libani and J. oxycedrus essential oils, while in P. pinea and J....

journal_title：Planta medica

authors： Saab AM,Guerrini A,Sacchetti G,Maietti S,Zeino M,Arend J,Gambari R,Bernardi F,Efferth T

更新日期：2012-12-01 00:00:00

abstract：:Enzymatic thrombin activity is significantly inhibited only by a few selected natural phenolic compounds (myricetin, rosmarinic acid, caffeic acid phenethyl ester) but more strongly by unsaturated fatty acids like erucic acid and oleic acids. Compared to the inhibitory potential against neutrophil elastase, thrombin a...

journal_title：Planta medica

authors： Melzig MF,Henke K

更新日期：2005-08-01 00:00:00

abstract：:Activator protein 1 (AP-1) is a transcription factor which plays a critical role in inflammation and carcinogenesis. The present study was conducted to investigate the effect of berberine, an isoquinoline alkaloid present in plants of the genera Berberis and Coptis, on the activity of AP-1 using a reporter gene assay ...

journal_title：Planta medica

authors： Fukuda K,Hibiya Y,Mutoh M,Koshiji M,Akao S,Fujiwara H

更新日期：1999-05-01 00:00:00

abstract：:The cytotoxicity of goniothalamin was found to be strong towards both cancerous (HGC-27, MCF-7, PANC-1, HeLa), and non-cancerous (3T3) cell lines, especially in cases of dividing cells. Drug exposure studies indicated that the cytotoxic action of goniothalamin was time- and dose-dependent. At the ultrastructural level...

journal_title：Planta medica

authors： Ali AM,Mackeen MM,Hamid M,Aun QB,Zauyah Y,Azimahtol HL,Kawazu K

更新日期：1997-02-01 00:00:00