Abstract:
:The cytotoxicity of goniothalamin was found to be strong towards both cancerous (HGC-27, MCF-7, PANC-1, HeLa), and non-cancerous (3T3) cell lines, especially in cases of dividing cells. Drug exposure studies indicated that the cytotoxic action of goniothalamin was time- and dose-dependent. At the ultrastructural level, goniothalamin-induced cytotoxicity revealed a necrotic mode of cell death towards MCF-7 cells.
journal_name
Planta Medjournal_title
Planta medicaauthors
Ali AM,Mackeen MM,Hamid M,Aun QB,Zauyah Y,Azimahtol HL,Kawazu Kdoi
10.1055/s-2006-957611subject
Has Abstractpub_date
1997-02-01 00:00:00pages
81-3issue
1eissn
0032-0943issn
1439-0221journal_volume
63pub_type
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