Antimalarial activity of biflavonoids from Ochna integerrima.

abstract：:A series of bitter secoiridoid glucosides isolated from various GENTIANA species (Gentianaceae) have been investigated by D/CI-MS. Amarogentin, amaropanin, amaroswerin, deglucosyltrifloroside, desacetylcentapicrin, gentiopicrin, swertiamarin and sweroside have been characterized by quasimolecular ions and typical frag...

journal_title：Planta medica

authors： Schaufelberger D,Domon B,Hostettmann K

更新日期：1984-10-01 00:00:00

abstract：:A callus was induced from the petiole of Panax ginseng C. A. Meyer by treatment with 2,4-D. The callus has been maintained on the synthetic media containing 2,4-D as growth factor. Habituated ginseng callus which required no auxin for its growth was induced from a 2,4-D callus by successive treatments with a low conce...

journal_title：Planta medica

authors： Furuya T,Yoshikawa T,Ishii T,Kajii K

更新日期：1983-03-01 00:00:00

abstract：:Hyperuricemia is a clinical condition characterized by an elevated level of serum uric acid and is a key risk factor for the development of gout and metabolic disorders. The existing urate-lowering therapies are often impractical for certain patient populations, providing a rationale to explore new agents with improve...

journal_title：Planta medica

authors： Kim JK,Kim WJ,Hyun JM,Lee JS,Kwon JG,Seo C,Song MJ,Choi CW,Hong SS,Park K,Kim P,Sung H,Lee JK,Choi Y

更新日期：2017-11-01 00:00:00

abstract：:The 2-mono- and 2,13-bis-glutathionyl adducts of helenalin and the 2-monoglutathionyl adduct of 11 alpha,13-dihydrohelenalin acetate were previously shown to be formed by spontaneous Michael addition at physiological pH. In living cells, glutathione (GSH) conjugation of many types of electrophilic agents is catalysed ...

journal_title：Planta medica

authors： Schmidt TJ

更新日期：2000-03-01 00:00:00

abstract：:The quantification of free and total alkannins in 13 endemic Anatolian Alkanna species is described for the first time. Extraction of the samples was performed by sonication with hexane, followed by hydrolysis in 1 N NaOH. For analysis, a new HPLC method, utilizing reversed phase material (Synergi Max RP), was develop...

journal_title：Planta medica

authors： Pekin G,Ganzera M,Senol S,Bedir E,Korkmaz KS,Stuppner H

更新日期：2007-03-01 00:00:00

abstract：:Purification of a cytotoxic crude alkaloid extract of Cassytha filiformis led to the isolation of four known aporphine alkaloids: neolitsine, dicentrine, cassythine (= cassyfiline) and actinodaphnine. Their structures were determined by analysis of spectroscopic data. All isolated alkaloids were tested for their cytot...

journal_title：Planta medica

authors： Stévigny C,Block S,De Pauw-Gillet MC,de Hoffmann E,Llabrès G,Adjakidjé V,Quetin-Leclercq J

更新日期：2002-11-01 00:00:00

abstract：:DNA barcoding methods originally developed for the identification of plant specimens have been applied to the authentication of herbal drug materials for industrial quality assurance. These methods are intended to be complementary to current morphological and chemical methods of identification. The adoption of these m...

journal_title：Planta medica

authors： Sgamma T,Lockie-Williams C,Kreuzer M,Williams S,Scheyhing U,Koch E,Slater A,Howard C

更新日期：2017-10-01 00:00:00

abstract：:Protopanaxatriol and protopanaxadiol exhibit limited oral bioavailability due to the poor solubility and intestinal cytochromes P450-mediated metabolism. This study set out to develop a novel cytochromes P450 inhibitory excipient(s)-based self-microemulsion to encapsulate protopanaxatriol and protopanaxadiol so as to ...

journal_title：Planta medica

authors： Yang F,Zhou J,Liu C,Hu X,Pan R,Chang Q,Liu X,Liao Y

更新日期：2017-03-01 00:00:00

abstract：:The isoflavonoids found in soy have attracted great interest as dietary phytoestrogens that might be effective for postmenopausal hormone replacement therapy. Special attention has been devoted to the hormonal effects of various isoflavonoids, like genistein (GEN) and daidzein's (DAID) potent metabolite, equol (EQ). H...

journal_title：Planta medica

authors： Tezval M,Sehmisch S,Seidlová-Wuttke D,Rack T,Kolios L,Wuttke W,Stuermer KM,Stuermer EK

更新日期：2010-02-01 00:00:00

abstract：:The dietary intake of flavonoids seems to be inversely related to cardiovascular mortality. The consumption of isoflavonoids is increasing in the general population, especially due to the use of food supplements and a variety of isoflavonoid-rich foods. However, detailed studies on the vascular influence of individual...

journal_title：Planta medica

authors： Migkos T,Pourová J,Vopršalová M,Auger C,Schini-Kerth V,Mladěnka P

更新日期：2020-07-01 00:00:00

abstract：:The pharmacokinetic profile of arctiin, the major active lignan in fruits of Arctium lappa L., was investigated. Its main meta"bolite arctigenin was identified by an LC-MS method, and an HPLC-UV technique was developed for the simultaneous quantification of the metabolite and arctiin in plasma and organs. Chromatograp...

journal_title：Planta medica

authors： He F,Dou DQ,Sun Y,Zhu L,Xiao HB,Kang TG

更新日期：2012-05-01 00:00:00

abstract：:In the course of our screening program for acyl-CoA : cholesterol acyltransferase (ACAT) inhibitors from Korean herbal medicines, ACAT inhibitors were isolated from the hairy roots of Panax ginseng (Araliaceae) and identified as panaxynol, panaxydol, panaxydiol, and panaxytriol. These active compounds inhibit rat live...

journal_title：Planta medica

authors： Kwon BM,Ro SH,Kim MK,Nam JY,Jung HJ,Lee IR,Kim YK,Bok SH

更新日期：1997-12-01 00:00:00

abstract：:Gas chromatography-flame ionization detection (GC-FID) was used to assess the chemical profile and quantification of cannabinoids to identify the differences, if existing, in the chemical constituents of in vitro propagated plants (IVP), conventionally grown plants (VP) and indoor grown mother plants (MP-Indoor) of a ...

journal_title：Planta medica

authors： Chandra S,Lata H,Mehmedic Z,Khan IA,ElSohly MA

更新日期：2010-05-01 00:00:00

abstract：:Solasodine--a steroid present in the mucilaginous exotesta of the seed in Solanum viarum Dunal (syn. S. khasianum var. chatterjeeanum) is a major source of steroidal raw material. Evidence for the site of solasodine synthesis was sought through reciprocal grafts involving steroid-bearing S. viarum (both diploid and au...

journal_title：Planta medica

authors： Srinivas M,Krishnan R

更新日期：1996-08-01 00:00:00

abstract：:Ulcerative colitis is a chronic inflammatory condition whose treatment includes aminosalicylates, corticosteroids, and immunomodulators. Medicinal plants seem to be an important alternative treatment for this condition. They have been the subject of a great number of studies in recent years. This study was conducted t...

journal_title：Planta medica

authors： Santana MT,Cercato LM,Oliveira JP,Camargo EA

更新日期：2017-05-01 00:00:00

abstract：:The leaves of Echinodorus grandiflorus are traditionally used in Brazil to treat several inflammatory conditions, including arthritis. This study aimed to investigate the antiarthritis activity of the 70% ethanol extract of E. grandiflorus leaves and a standardized flavonoid-rich fraction in an antigen-induced arthrit...

journal_title：Planta medica

authors： Garcia Ede F,de Oliveira MA,Candido LC,Coelho FM,Costa VV,Queiroz-Junior CM,Boff D,Amaral FA,de Souza Dda G,Teixeira MM,Braga FC

更新日期：2016-03-01 00:00:00

abstract：:We present the application of the generative topographic map algorithm to visualize the chemical space populated by natural products and synthetic drugs. Generative topographic maps may be used for nonlinear dimensionality reduction and probabilistic modeling. For compound mapping, we represented the molecules by two-...

journal_title：Planta medica

authors： Miyao T,Reker D,Schneider P,Funatsu K,Schneider G

更新日期：2015-04-01 00:00:00

abstract：:Bisbenzylisoquinoline alkaloids are known to affect immune responses as well as inflammatory responses, and have been used for the treatment of inflammatory symptoms in China. This study is aimed at elucidating the inhibitory effects of two alkaloids, fangchinoline and isotetrandrine, on the induction of the proinflam...

journal_title：Planta medica

authors： Onai N,Tsunokawa Y,Suda M,Watanabe N,Nakamura K,Sugimoto Y,Kobayashi Y

更新日期：1995-12-01 00:00:00

abstract：:This study demonstrated that plant extracts containing acetylenic isobutylamides and polyacetylenes, previously reported as occurring in Echinacea, have phototoxic antimicrobial activity against fungi, including clinically relevant pathogenic fungi. Results show that hexane extracts of Echinacea variably inhibit growt...

journal_title：Planta medica

authors： Binns SE,Purgina B,Bergeron C,Smith ML,Ball L,Baum BR,Arnason JT

更新日期：2000-04-01 00:00:00

abstract：:An efficient in vitro propagation protocol for rapidly producing Cannabis sativa plantlets from young leaf tissue was developed. Using gas chromatography-flame ionization detection (GC-FID), high THC yielding elite female clone of a drug-type CANNABIS variety (MX) was screened and its vegetatively propagated clones we...

journal_title：Planta medica

authors： Lata H,Chandra S,Khan IA,Elsohly MA

更新日期：2010-10-01 00:00:00

abstract：:Lipophilic extracts of Isatis tinctoria L. exhibit significant activity against several clinically relevant targets of inflammation. The alkaloid tryptanthrin was identified as one of the active principles in woad and characterised as a potent dual inhibitor of COX-2 and 5-LOX. Here, the anti-inflammatory efficacy of ...

journal_title：Planta medica

authors： Heinemann C,Schliemann-Willers S,Oberthür C,Hamburger M,Elsner P

更新日期：2004-05-01 00:00:00

abstract：:A method was developed to distinguish Vaccinium species based on leaf extracts using nuclear magnetic resonance spectroscopy. Reference spectra were measured on leaf extracts from several species, including lowbush blueberry (Vaccinium angustifolium), oval leaf huckleberry (Vaccinium ovalifolium), and cranberry (Vacci...

journal_title：Planta medica

authors： Markus MA,Ferrier J,Luchsinger SM,Yuk J,Cuerrier A,Balick MJ,Hicks JM,Killday KB,Kirby CW,Berrue F,Kerr RG,Knagge K,Gödecke T,Ramirez BE,Lankin DC,Pauli GF,Burton I,Karakach TK,Arnason JT,Colson KL

更新日期：2014-06-01 00:00:00

abstract：:Mulberroside A, a major stilbene constituent of MORUS ALBA L. (Moraceae), displays significant antitussive and antiasthmatic effects in animals. As part of our ongoing research on its biotransformation in rats, mulberroside A was orally administered to rats, and the metabolites in the gastrointestinal contents and fec...

journal_title：Planta medica

authors： Zhaxi M,Chen L,Li X,Komatsu K,Yao X,Qiu F

更新日期：2010-03-01 00:00:00

abstract：:The hypoglycemic activity of olive leaf was studied. Maximum hypoglycemic activity was obtained from samples collected in the winter months, especially in February. One of the compounds responsible for this activity was oleuropeoside, which showed activity at a dose of 16 mg/kg. This compound also demonstrated antidia...

journal_title：Planta medica

authors： Gonzalez M,Zarzuelo A,Gamez MJ,Utrilla MP,Jimenez J,Osuna I

更新日期：1992-12-01 00:00:00

abstract：:Four new isoprenylated xanthones, cudraxanthones A, B and C were isolated from the N-hexane extract of the root bark of CUDRANIA TRICUSPIDATA (Carr.) Bur. (Japanese name "Hariguwa"; Moraceae), and cudraxanthone D from the benzene extract. The structures of cudraxanthones A, B, C and D were shown to be 1-4, respectivel...

journal_title：Planta medica

authors： Fujimoto T,Hano Y,Nomura T

更新日期：1984-06-01 00:00:00

abstract：:This in vitro study aimed to determine the effects of a Panax ginseng extract on aristolochic acid-mediated toxicity in HK-2 cells. A methanolic extract of ginseng (50 µg/mL) was able to reduce cell survival after treatment with 50 µM aristolochic acid for 24, 48, and 72 h, as evidenced by a resazurin reduction assay....

journal_title：Planta medica

authors： Bunel V,Antoine MH,Nortier J,Duez P,Stévigny C

更新日期：2015-03-01 00:00:00

abstract：:Volatile constituents of the essential oils from leaves and inflorescences of Solidago chilensis Meyen were analyzed by GC-FID, GC-MS and 13C-NMR and thirty-six different compounds were identified. Pumiloxide, an unusual labdane diterpene, was found to be one of the major components in both oils (15.3 % and 12.3 %, re...

journal_title：Planta medica

authors： Vila R,Mundina M,Tomi F,Furlán R,Zacchino S,Casanova J,Cañigueral S

更新日期：2002-02-01 00:00:00

abstract：:Our investigations into the stability of tincture preparations of milk thistle fruit [ Silybum marianum L. Gaertn. (Asteraceae)] have led to the characterization of a new flavonolignan 4-(4-hydroxy-3-methoxyphenyl)-7-[(2 R,3 R)-3,5,7-trihydroxy-4-oxochroman-2-yl]-1-oxo-1,3,3a,4,5,7a-hexahydro-2-benzofuran-5-carboxylic...

journal_title：Planta medica

authors： MacKinnon SL,Hodder M,Craft C,Simmons-Boyce J

更新日期：2007-09-01 00:00:00

abstract：:Effects of passage of subculture and several culture conditions, nutritional, hormonal and light conditions on 3,4-dihydroxyphenylalanine (DOPA) content were examined in callus of STIZOLOBIUM HASSJOO P IPER and T RACY. The favourable conditions for DOPA accumulation were found to be suboptimal conditions for growth, i...

journal_title：Planta medica

authors： Obata-Sasamoto H,Komamine A

更新日期：1983-10-01 00:00:00

abstract：:Piper methysticum (Kava) is a plant whose roots are used in the preparation of traditional beverages with spiritual, medicinal, and social importance for the Pacific Islanders. Kava is also sold as a herbal supplement or recreational beverage consumed for its mild inebriating effect in Europe and North America. With a...

journal_title：Planta medica

authors： Liu Y,Lund JA,Murch SJ,Brown PN

更新日期：2018-11-01 00:00:00