Light-mediated antifungal activity of Echinacea extracts.


:This study demonstrated that plant extracts containing acetylenic isobutylamides and polyacetylenes, previously reported as occurring in Echinacea, have phototoxic antimicrobial activity against fungi, including clinically relevant pathogenic fungi. Results show that hexane extracts of Echinacea variably inhibit growth of yeast strains of Saccharomyces cerevisiae, Candida shehata, C. kefyr, C. albicans, C. steatulytica and C. tropicalis under near UV irradiation (phototoxicity) and to a lower extent without irradiation (conventional antifungal activity). The presence of polyacetylenes and alkylamides in extracts of different organs was confirmed in Echinacea purpurea by HPLC in agreement with previously reported data in the literature, and was related to phototoxic activity. Two representative pure compounds, undeca-2E,4Z-diene-8,10-diynoic acid isobutylamide and dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamide, were isolated from Echinacea purpurea root extracts, and compared in a disk assay (5 micrograms/disk) with the highly conjugated trideca-1-ene-3,5,7,9,10-pentayne (previously isolated in our laboratory and found here in E. purpurea). Significant phototoxicity was demonstrated by pure trideca-1-ene-3,5,7,9,10-pentayne, while only minor phototoxicity was induced by the other two acetylenic compounds. Phototoxic activity of Echinacea spp. is primarily attributed to the ketoalkenes and ketoalkynes abundantly present in the roots.


Planta Med


Planta medica


Binns SE,Purgina B,Bergeron C,Smith ML,Ball L,Baum BR,Arnason JT




Has Abstract


2000-04-01 00:00:00












  • Cloning and characterization of a cDNA coding a hydroxycinnamoyl-CoA quinate hydroxycinnamoyl transferase involved in chlorogenic acid biosynthesis in Lonicera japonica.

    abstract::The flower buds of Lonicera japonica are widely used in Chinese medicine for their anti-inflammatory properties. The reason why L. japonica has potent and significant effects is that it contains various active components, especially chlorogenic acid (CGA). In the present study, we isolated a hydroxycinnamoyl-CoA quina...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Peng X,Li W,Wang W,Bai G

    更新日期:2010-11-01 00:00:00

  • Antiherpetic activities of sulfated polysaccharides from green algae.

    abstract::In order to evaluate the potency of novel antiviral drugs, 11 natural sulfated polysaccharides (SPs) from 10 green algae ( Enteromorpha compressa, Monostroma nitidum, Caulerpa brachypus, C. okamurai, C. scapelliformis, Chaetomorpha crassa, C. spiralis, Codium adhaerens, C. fragille, and C. latum) and 4 synthetic sulfa...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Lee JB,Hayashi K,Maeda M,Hayashi T

    更新日期:2004-09-01 00:00:00

  • Incomptines C and D, two heliangolides from Decachaeta incompta and their antiprotozoal activity.

    abstract::Two new heliangolides, incomptines C (3) and D (4), were isolated from the leaves of Decachaeta incompta. The structures were established by spectroscopic methods and confirmed by X-ray crystallography. The antiprotozoal activity of incomptines C and D was evaluated. Additionally, the chromatographic profile of the le...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Bautista E,Calzada F,Yepez-Mulia L,Chavez-Soto M,Ortega A

    更新日期:2012-10-01 00:00:00

  • Antibacterial properties of phenolic triterpenoids against Staphylococcus epidermidis.

    abstract::Two phenolic triterpenoids, pristimerol (30 µg/mL) and 8- EPI-6-deoxoblepharodol (20 µg/mL), obtained by catalytic reduction of pristimerin, exhibited bacteriostatic action against Staphylococcus epidermidis. This activity was not dependent on the inoculum size and the growth phase although it showed a stronger effect...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: López MR,de León L,Moujir L

    更新日期:2011-05-01 00:00:00

  • Chemical constituents from the stem bark of Trewia nudiflora L. and their antioxidant activities.

    abstract::Three new compounds, namely, (+)-dihydrodehydrodiconiferyl alcohol 4- O- beta-(6''- O-galloyl)-glucopyranoside ( 1), 4,4'- O-dimethylellagic acid 3-(2''- O-acetyl)- alpha-rhamnopyranoside ( 2), and ethyl O- beta-(6'-galloyl)-glucopyranoside ( 3), together with eleven known ones, were isolated from the stem bark of Tre...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Kang QJ,Yang XW,Wu SH,Ma YL,Li L,Shen YM

    更新日期:2008-03-01 00:00:00

  • Desorption/Chemical ionization mass spectrometry of bitter glycosides from gentiana1.

    abstract::A series of bitter secoiridoid glucosides isolated from various GENTIANA species (Gentianaceae) have been investigated by D/CI-MS. Amarogentin, amaropanin, amaroswerin, deglucosyltrifloroside, desacetylcentapicrin, gentiopicrin, swertiamarin and sweroside have been characterized by quasimolecular ions and typical frag...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Schaufelberger D,Domon B,Hostettmann K

    更新日期:1984-10-01 00:00:00

  • Bioactive polyacetylenes from Bidens pilosa.

    abstract::From the methanolic extract of the whole plants of Bidens pilosa the new beta-D-glucopyranosyloxy-3-hydroxy-6(E)-tetradecen-8, 10,12-triyne besides a known polyine has been isolated and identified mainly by IR and NMR methods. The new compound showed overgrowing action against normal and transformed human cell lines i...

    journal_title:Planta medica

    pub_type: 信件


    authors: Alvarez L,Marquina S,Villarreal ML,Alonso D,Aranda E,Delgado G

    更新日期:1996-08-01 00:00:00

  • Sarothrin from Alkanna orientalis is an antimicrobial agent and efflux pump inhibitor.

    abstract::An Alkanna orientalis leaf and flower extract inhibited the growth of Staphylococcus aureus, a pathogen that causes an estimated 478 000 hospitalizations in the US annually. Bioassay-guided fractionation of A. orientalis resulted in isolation of the flavonoid sarothrin (5,7,4'-trihydroxy-3,6,8-trimethoxyflavone), whic...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Bame JR,Graf TN,Junio HA,Bussey RO 3rd,Jarmusch SA,El-Elimat T,Falkinham JO 3rd,Oberlies NH,Cech RA,Cech NB

    更新日期:2013-03-01 00:00:00

  • Two new 8-oxotetrahydroprotoberberine alkaloids, gusanlung A and B, from Acangelisia gusanlung.

    abstract::Two new 8-oxotetrahydroprotoberberine alkaloids, gusanlung A(1) and B(2), together with known isoquinoline alkaloids, berberine and jatrorrhizine, were isolated from the Chinese medicinal plant Acangelisia gusanlung H. S. Lo (Menispermaceae). Their structures were elucidated mainly by spectroscopic analysis. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Zhang JS,Chen ZL

    更新日期:1991-10-01 00:00:00

  • Neurotropic action of the hydroalcoholic extract of Melissa officinalis in the mouse.

    abstract::A lyophilised hydroalcoholic extract of Melissa officinalis L. (Lamiaceae) has been evaluated for behavioral effects in mice. According to the traditional use of M. officinalis, sedative properties have been confirmed for low doses by the decrease of behavioral parameters measured in a non-familiar environment test (s...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Soulimani R,Fleurentin J,Mortier F,Misslin R,Derrieu G,Pelt JM

    更新日期:1991-04-01 00:00:00

  • Investigation of the Alkaloid Content of Rauwolfia serpentina Roots from Regenerated Plants.

    abstract::The indole alkaloid content of RAUWOLFIA SERPENTINA roots from regenerated plants (from stem-and root-callus) was compared with the parental stock. Although the total alkaloid content seems to be slightly higher in the roots from regenerated plants, HPLC-analysis of individual alkaloids indicated that the contents of ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Ruyter CM,Akram M,Illahi I,Stöckigt J

    更新日期:1991-08-01 00:00:00

  • Croblongifolin, a new anticancer clerodane from Croton oblongifolius.

    abstract::A new furoclerodane, croblongifolin, together with one known clerodane, crovatin and one known labdane, nidorellol, were isolated from the stem bark of Croton oblongifolius. Structures were established based on spectroscopic and X-ray analysis. Croblongifolin showed a significant cytotoxicity against various human tum...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Roengsumran S,Musikul K,Petsom A,Vilaivan T,Sangvanich P,Pornpakakul S,Puthong S,Chaichantipyuth C,Jaiboon N,Chaichit N

    更新日期:2002-03-01 00:00:00

  • Chemography of natural product space.

    abstract::We present the application of the generative topographic map algorithm to visualize the chemical space populated by natural products and synthetic drugs. Generative topographic maps may be used for nonlinear dimensionality reduction and probabilistic modeling. For compound mapping, we represented the molecules by two-...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Miyao T,Reker D,Schneider P,Funatsu K,Schneider G

    更新日期:2015-04-01 00:00:00

  • p-Terphenyl- and phenanthraquinone derivatives: an NMR study.

    abstract::(1)H- and (13)C-NMR spectral data are presented for six p-terphenylquinone derivatives (and for two monosubstituted quinones 1 and 2, used as model compounds) and for 9,10-phenanthraquinone and retenequinone. The chemical shifts were confirmed through correlation spectroscopy and NOE measurements. ...

    journal_title:Planta medica

    pub_type: 信件


    authors: Jokela R,Lounasmaa M

    更新日期:1997-08-01 00:00:00

  • Inhibitory effects of bisbenzylisoquinoline alkaloids on induction of proinflammatory cytokines, interleukin-1 and tumor necrosis factor-alpha.

    abstract::Bisbenzylisoquinoline alkaloids are known to affect immune responses as well as inflammatory responses, and have been used for the treatment of inflammatory symptoms in China. This study is aimed at elucidating the inhibitory effects of two alkaloids, fangchinoline and isotetrandrine, on the induction of the proinflam...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Onai N,Tsunokawa Y,Suda M,Watanabe N,Nakamura K,Sugimoto Y,Kobayashi Y

    更新日期:1995-12-01 00:00:00

  • Salvia plebeia Extract Inhibits Xanthine Oxidase Activity In Vitro and Reduces Serum Uric Acid in an Animal Model of Hyperuricemia.

    abstract::Hyperuricemia is a clinical condition characterized by an elevated level of serum uric acid and is a key risk factor for the development of gout and metabolic disorders. The existing urate-lowering therapies are often impractical for certain patient populations, providing a rationale to explore new agents with improve...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Kim JK,Kim WJ,Hyun JM,Lee JS,Kwon JG,Seo C,Song MJ,Choi CW,Hong SS,Park K,Kim P,Sung H,Lee JK,Choi Y

    更新日期:2017-11-01 00:00:00

  • Endophytic fungal metabolite fumigaclavine C causes relaxation of isolated rat aortic rings.

    abstract::Two indole alkaloids were isolated from the culture of Aspergillus fumigatus (strain No. CY018), an endophytic fungus harboring inside the elder leaf of Cynodon dactylon. These two chemicals were identified as fumigaclavine C and fumitremorgin C. In screening the bioactivity of these two indole alkaloids, their vasore...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Ma HY,Song YC,Mao YY,Jiang JH,Tan RX,Luo L

    更新日期:2006-04-01 00:00:00

  • Honokiol induces apoptosis via cytochrome c release and caspase activation in activated rat hepatic stellate cells in vitro.

    abstract::The therapeutic goal in liver fibrosis is the reversal of fibrosis and the selective clearance of activated hepatic stellate cells (HSCs) by inducing apoptosis. Over the past several years, we have screened for natural products that mediate apoptosis in activated HSCs. Among the candidate compounds, honokiol, isolated...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Park EJ,Zhao YZ,Kim YH,Lee BH,Sohn DH

    更新日期:2005-01-01 00:00:00

  • Comparison of the inhibitory effects of monomeric, dimeric, and trimeric procyanidins on the biochemical markers of skin tumor promotion in mouse epidermis in vivo.

    abstract::Several procyanidin dimers and an epicatechin trimer purified from Douglas fir bark tannins were compared with their monomer components (+)-catechin and (-)-epicatechin for their abilities to inhibit the biochemical effects of the potent tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) in mouse epidermis in v...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Gali HU,Perchellet EM,Gao XM,Karchesy JJ,Perchellet JP

    更新日期:1994-06-01 00:00:00

  • Protective Effects of Bacopa Monnieri on Hydrogen Peroxide and Staurosporine: Induced Damage of Human Neuroblastoma SH-SY5Y Cells.

    abstract::Many herbs, and recently their biomass from in vitro cultures, are essential for the treatment of diseases. The aim of this study was to determine the optimal growth of Bacopa monnieri (water hyssop) in an in vitro culture and to examine if extracts of the B. monnieri biomass from the in vitro culture would affect hyd...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Łojewski M,Pomierny B,Muszyńska B,Krzyżanowska W,Budziszewska B,Szewczyk A

    更新日期:2016-02-01 00:00:00

  • Naturally occurring norephedrine oxazolidine derivatives in khat (Catha edulis).

    abstract::Khat (Catha edulis Forsk.) is a perennial shrub whose young leaves are chewed for their psychostimulating and anorectic properties. The main active principles of khat are believed to be the phenylpropylamino alkaloids, primarily (-)-cathinone [(S)-α-aminopropiophenone], (+)-cathine [(1S)(2S)-norpseudoephedrine], and (...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Krizevski R,Bar E,Dudai N,Levy A,Lewinsohn E,Sitrit Y,Ben-Shabat S

    更新日期:2012-05-01 00:00:00

  • Extracts from Pygeum africanum and other ethnobotanical species with antiandrogenic activity.

    abstract::Extracts from Pygeum africanum, Serenoa repens and Cucurbita pepo are used in the treatment of benign prostatic hyperplasia (BPH) and prostate cancer (PCa). The activity of the androgen receptor (AR) is known to control growth of the prostate. Here, we examined extracts of these plants for their antiandrogenic activit...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Schleich S,Papaioannou M,Baniahmad A,Matusch R

    更新日期:2006-07-01 00:00:00

  • Differentiation of the traditional Chinese medicinal plants Euphorbia humifusa and E. maculata from adulterants by TaqMan real-time polymerase chain reaction.

    abstract::DNA sequence analysis of the rDNA internal transcribed spacer 1 (ITS1) and TaqMan real-time polymerase chain reaction were exploited for their applications in the differentiation of the traditional chinese medicinal plants euphorbia humifusa and e. maculata from three related adulterants e. hypericifolia, E. atoto and...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Xue HG,Wang H,Li DZ,Xue CY,Wang QZ

    更新日期:2008-02-01 00:00:00

  • An anti-inflammatory ent-kaurane from the stems of Annona squamosa that inhibits various human neutrophil functions.

    abstract::We have previously shown that 11 ent-kauranes isolated from the stems of Annona squamosa exhibited immunomodulating effects in leukocytes. In this study, a cellular model using isolated human neutrophils, which are important in the pathogenesis of rheumatoid arthritis, ischemia-reperfusion injury, chronic obstructive ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Yeh SH,Chang FR,Wu YC,Yang YL,Zhuo SK,Hwang TL

    更新日期:2005-10-01 00:00:00

  • Molecular Identification Based on Chloroplast Sequences and Anti-complementary Activity Comparison of Juniperus Samples from the Qinghai-Tibet Plateau.

    abstract::Juniperus (Cupressaceae, Pinales) plants are widely distributed in the Qinghai-Tibet Plateau of China. The leaves and twigs of at least 8 Juniperus species (J. pingii, J. pingii var. wilsonii, J. squamata, J. recurva var. coxii, J. saltuaria, J. indica, J. tibetica and J. convallium var. microsperma) have been used as...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Yang YT,De J,Fu ZL,Wang XL,Chen DF,Xie H,Lu Y

    更新日期:2020-11-01 00:00:00

  • Antiplasmodial alkaloids from the stem bark of Strychnos malacoclados.

    abstract::From the stem bark of Strychnos malacoclados, one new bisindole alkaloid, 3-hydroxylongicaudatine Y (1), was isolated along with the known alkaloids vomicine (2), bisnordihydrotoxiferine (3), divarine (4), longicaudatine (5), longicaudatine Y (6), and longicaudatine F (7). All the compounds were tested for their antim...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Tchinda AT,Ngono AR,Tamze V,Jonville MC,Cao M,Angenot L,Frédérich M

    更新日期:2012-03-01 00:00:00

  • Antineoplastic agents. II. Four furostanol glycosides from rhizomes of Dioscorea collettii var. hypoglauca.

    abstract::During activity-guided fractionations to screen for antineoplastic agents, further studies by means of preparative HPLC led to the isolation of four known furostanol saponins: protoneodioscin, protodioscin, protoneogracillin, protogracillin, along with their corresponding artifacts: methyl protoneodioscin, methyl prot...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Hu K,Dong A,Yao X,Kobayashi H,Iwasaki S

    更新日期:1997-04-01 00:00:00

  • Assay of volatile oil-cyclodextrin complexes by pyrolyzis gas-chromatography.

    abstract::A pyrolytic gaschromatographic process was developed for the routine assay of both cyclodextrin inclusion complexes, and for the differentiation of the mechanical mixture of the same oil with beta-cyclodextrin. The method is a direct assay of low material demand. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Pobozsny K,Kernóczi L,Tétényi P,Héthelyi I,Szejtli J

    更新日期:1981-07-01 00:00:00

  • Peltogynoids and 2-phenoxychromones from Peltophorum pterocarpum and evaluation of their estrogenic activity.

    abstract::Phytochemical investigation of the dichloromethane extract of the leaves of Peltophorum pterocarpum, a tropical ornamental tree, led to the isolation of twelve compounds (1-12). One new derivative of peltogynoid ophioglonin (1) and a new 2-phenoxychromone (2) with its 3'-O-β-D-glucoside derivative (3) are described he...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Polasek J,Queiroz EF,Marcourt L,Meligova AK,Halabalaki M,Skaltsounis AL,Alexis MN,Prajogo B,Wolfender JL,Hostettmann K

    更新日期:2013-04-01 00:00:00

  • The selective antianginal effect without changing blood pressure of butylidenephthalide in conscious rats.

    abstract::Synthetic butylidenephthalide (Bdph), 60 mg/kg per os (p.o.) given 3 h prior to injection of pituitrin (4 U/kg, i.v.), significantly prevented T-wave lowering on lead II electrocardiograph in unanesthetized rats. The effective dose, 60 mg/kg, was about 1/56th of the median lethal dose (LD50, p.o.) in rats. However, Bd...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Ko WC,Sheu JR,Tzeng SH,Chen CM

    更新日期:1998-04-01 00:00:00