Antifungal chromans inhibiting the mitochondrial respiratory chain of pea seeds and new xanthones from Calophyllum caledonicum.

Abstract:

:Two new xanthones, caledonixanthone M 1 and caloxanthone L 2, and one new acid, caledonic acid 6 were isolated from the hexane-soluble extract of the stem bark of Calophyllum caledonicum. In the course of this phytochemical study, seven other known compounds - calothwaitesixanthone, calozeyloxanthone, allanxanthone, isoapetalic acid 3, calolongic acid 4, apetalic acid 5 and isocalolongic acid 7 - were isolated. Their antifungal activity against the growth of the human pathogenic fungus Aspergillus fumigatus was then investigated. The results indicated that the crude extract, calolongic acid 4 and isocalolongic acid 7 exhibited strong inhibitory effects with MIC (80) values of 8, 4, 2 microg/mL, respectively. Besides, calolongic acid 4, its lactone derivative 4a and isocalolongic acid 7 markedly reduced the respiration of pea seed mitochondria.

journal_name

Planta Med

journal_title

Planta medica

authors

Hay AE,Guilet D,Morel C,Larcher G,Macherel D,Le Ray AM,Litaudon M,Richomme P

doi

10.1055/s-2003-818004

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

1130-5

issue

12

eissn

0032-0943

issn

1439-0221

journal_volume

69

pub_type

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