Abstract:
:In this study, hemolysis, Western blot, and real-time RT-PCR assays were performed to evaluate silibinin's activity against S. aureus α-toxin secretion. In addition, live/dead cell staining and lactate dehydrogenase activity assays were introduced to examine the influence of silibinin on α-toxin-induced cell injury in human alveolar epithelial cells. Furthermore, we tested the influence of silibinin on S. aureus pneumonia in a mouse model. We show that silibinin inhibits the expression of α-toxin in a dose-dependent manner and alleviates α-toxin-induced lung cell injury. The IC50 of silibinin that inhibits the hemolytic activity of S. aureus was 14.33 µg/mL for strain 8325-4. Moreover, this compound provides effective protection on the lung injury of staphylococcal pneumonia.
journal_name
Planta Medjournal_title
Planta medicaauthors
Wang X,Dong J,Dai X,Zhang Y,Wang J,Li H,Lu C,Tan W,Gao X,Deng X,Bu S,Niu Xdoi
10.1055/s-0032-1328068subject
Has Abstractpub_date
2013-01-01 00:00:00pages
110-5issue
2eissn
0032-0943issn
1439-0221journal_volume
79pub_type
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