Abstract:
:Valepotriates are iridoids found in variable amounts in Valerianaceae and might be among the bioactive compounds which confer anxiolytic properties to the Valeriana species. On the other hand, unspecific cytotoxicity has also been described. Presently, however, no particular molecular target has been defined for these compounds. Here we studied the effect of valtrate, acevaltrate, and 1- β-acevaltrate isolated from Valeriana glechomifolia on the enzymatic activity of rat P-type ATPases. Valepotriates did not affect rat skeletal muscle sarco/endoplasmic reticulum Ca²⁺-ATPase (SERCA) activity at the highest concentration used (100 µM). In contrast, the same concentration inhibited roughly half of the total H⁺/K⁺-ATPase activity from rat gastric epithelium (valtrate 54.6 ± 3.2 %, acevaltrate 60.7 ± 7.3 %, 1- β-acevaltrate 50.2 ± 3.1 %; mean ± SEM, n = 3-5). Finally, these substances showed the highest inhibitory potency toward Na⁺/K⁺-ATPase, and the inhibition curves obtained provided a similar IC₅₀ (in µM) for rat kidney α1 isoform (valtrate 21.2, acevaltrate 22.8, 1- β-acevaltrate 24.4) and brain hemispheres α2/ α3 isoforms (valtrate 19.4, acevaltrate 42.3, 1- β-acevaltrate 38.3). Our results suggest that P-type ATPases are differentially inhibited by valepotriates and that Na⁺/K⁺-ATPase might be one of their molecular targets in vivo.
journal_name
Planta Medjournal_title
Planta medicaauthors
Bettero GM,Salles L,Rosário Figueira RM,Poser Gv,Rates SM,Noël F,Quintas LEdoi
10.1055/s-0030-1271084subject
Has Abstractpub_date
2011-10-01 00:00:00pages
1702-6issue
15eissn
0032-0943issn
1439-0221journal_volume
77pub_type
杂志文章相关文献
PLANTA MEDICA文献大全abstract::An efficient in vitro propagation protocol for rapidly producing Cannabis sativa plantlets from young leaf tissue was developed. Using gas chromatography-flame ionization detection (GC-FID), high THC yielding elite female clone of a drug-type CANNABIS variety (MX) was screened and its vegetatively propagated clones we...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0030-1249773
更新日期:2010-10-01 00:00:00
abstract::A sensitive and rapid liquid chromatography-mass spectrometric method for the determination of ophiopogonin D in rat plasma was developed and validated. Chromatographic separation was performed on a C (18) column using a step gradient program with the mobile phase of 0.5 mmol/L ammonium chloride solution and acetonitr...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0028-1088339
更新日期:2008-12-01 00:00:00
abstract::A series of mainly marine derived natural products were tested for their activities against Mycobacterium tuberculosis and M. avium. Of the thirty-nine compounds tested fifteen demonstrated minimum inhibition concentrations (MICs) of 32 micrograms/ml or less, and eleven had MICs of 16 micrograms/ml or less. The most a...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2000-8534
更新日期:2000-05-01 00:00:00
abstract::Three new dammar-type triterpenoid caffeates (1-3) were isolated from the stalks of Celastrus rosthornianus Loes. Their structures were established through various spectral studies as 3beta,20(S),24(S)-trihydroxyldammar-25-ene 3-caffeate (1), 3beta,20(S),24(R)-trihydroxyldammar-25-ene 3-caffeate (2) and 3beta,20(S),25...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-916214
更新日期:2006-03-01 00:00:00
abstract::Nano-encapsulation of several natural products has become an important tool in enhancing the bioavailability of some modern drugs against many diseases. Pelargonidin is an anthocyanidin found in many fruits and vegetables. Pelargonidin is loaded with poly-lactide-co-glycolic-acid, a non-toxic biodegradable polymer, to...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0043-100017
更新日期:2017-03-01 00:00:00
abstract::The anti-inflammatory effects of boldine and reticuline isolated from Litsea cubeba were evaluated by using xylene-induced ear edema and carrageenan-induced paw edema in mice and rats. Our results demonstrated that intragastric administration with boldine and reticuline significantly mitigated ear weight in mice and d...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0043-113447
更新日期:2018-01-01 00:00:00
abstract::High molecular compounds from Chinese herbal medicines, including ribosome-inactivating proteins and polysaccharides from both fungi and high plants have been tested for the treatment of malignant diseases. Polysaccharides possessing immunostimulating activities can be used as adjuvants in tumor treatment. The fungi c...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-2003-38494
更新日期:2003-03-01 00:00:00
abstract::The indole alkaloid content of RAUWOLFIA SERPENTINA roots from regenerated plants (from stem-and root-callus) was compared with the parental stock. Although the total alkaloid content seems to be slightly higher in the roots from regenerated plants, HPLC-analysis of individual alkaloids indicated that the contents of ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-960109
更新日期:1991-08-01 00:00:00
abstract::Hepatocellular carcinoma is one of the leading causes of malignancy-related death in China. Its therapy in clinics is a big challenge. Ginsenoside Rh2 is one of the most notable cancer-preventing components from red ginseng and it has been reported that ginsenoside Rh2 exhibited potent cytotoxicity against human hepat...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-101764
更新日期:2016-05-01 00:00:00
abstract::The involvement of unfolded protein response (UPR) activation in tumor survival and resistance to chemotherapies suggests a new anticancer strategy targeting UPR pathway. Arctigenin, a natural product, has been recently identified for its antitumor activity with selective toxicity against cancer cells under glucose st...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0030-1250179
更新日期:2011-01-01 00:00:00
abstract::As an exploratory investigation of antimicrobial promoting compounds, 3- O-acyl-(-)-epicatechins and 3- O-acyl-(+)-catechins possessing various aromatic groups and aliphatic chains of varying length from C4 to C16 for increasing lipophilicity were synthesized and tested for antimicrobial activities against Gram-positi...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2004-818923
更新日期:2004-03-01 00:00:00
abstract::This paper reports the phytochemical investigation of the 50% aq. EtOH extract of Houttuynia cordata, an effective TCM and functional food in China, which led to the isolation of 17 flavonoids including four new ones. The four new compounds were flavonoid derivatives tethered with houttuynin (3-oxododecanal). Each of ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0033-1351051
更新日期:2013-12-01 00:00:00
abstract::The crude ethanol extract from the leaves of Dendropanax arboreus (Araliaceae) from Monteverde, Costa Rica, exhibits cytotoxic activity against Hep-G2, A-431, H-4IIE, and L-1210 tumor cell lines, but is not toxic against normal hepatocytes. The active component has been isolated by activity-directed separation and ide...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-958139
更新日期:1995-10-01 00:00:00
abstract::HPLC determinations of the aescin contents in calli and embryoids from leaf explants of AESCULUS HIPPOCASTANUM L. were carried out in order to determine whether it was possible to obtain aescin-forming proliferations IN VITRO. The results indicate that embryogenic calli and embryoids derived from them produce an amoun...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-960016
更新日期:1991-02-01 00:00:00
abstract::The composition of the phthalide mixture of the essential oil from roots of Levisticum officinale Koch was investigated. The phthalide mixture was analyzed by combining separation methods - GLC, LSC and TLC - and subsequently using spectroscopic methods - IR, MS and NMR. E- and Z-butylidenephthalide, E- and Z-ligustil...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-971448
更新日期:1982-04-01 00:00:00
abstract::The traditional therapeutic indications for the use of Morinda citrifolia L. (Rubiaceae) have been investigated. The lyophilised aqueous extract of roots of M. citrifolia was evaluated for analgesic and behavioural effects in mice. The extract did not exhibit any toxic effects but did show a significant, dose-related,...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-961004
更新日期:1990-10-01 00:00:00
abstract::Guinea pigs were sensitized with trinitrophenylated liver macromolecular protein fraction (TNP-LP1) prepared by using sodium trinitrobenzenesulfonate of strong immunogenicity as the hapten and LP1 as the carrier protein. The administration of trinitrophenylated hepatocytes and lipopolysaccharide to these TNP-LP1-sensi...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-960006
更新日期:1991-02-01 00:00:00
abstract::Different oil-samples of Melissa officinalis L. were analysed by capillary GC/MS, using fused silica columns and E.I.-Mass-spectrometry. Comparing the observed mass-spectra with those of a spectral collection, 70 compounds of the oil were identified. Geranial, neral, 6-methyl-5-hepten-2-one, citronellal, geranyl-aceta...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-970028
更新日期:1982-10-01 00:00:00
abstract::A new cytotoxic roridin-type trichothecene macrolide named roritoxin E(1) was characterized from the solid culture of Myrothecium roridum IFB-E091 (residing originally inside Artemisia annua root), together with the known compounds lumichrome (2), (22 E,24 S)-cerevisterol (3), and (22 E,24 R)-6 beta-methoxy-ergosta-7,...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-0029-1240897
更新日期:2010-07-01 00:00:00
abstract::DNA barcoding methods originally developed for the identification of plant specimens have been applied to the authentication of herbal drug materials for industrial quality assurance. These methods are intended to be complementary to current morphological and chemical methods of identification. The adoption of these m...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-0043-113448
更新日期:2017-10-01 00:00:00
abstract::Danggui buxue tang, an ancient formula composed of astragali radix and Angelicae sinensis radix, has been used for treating menopausal irregularity in women for more than 800 years in China. In danggui buxue tang, the complete functions of astragali radix require the assistance of Angelicae sinensis radix, and both he...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0033-1360314
更新日期:2014-02-01 00:00:00
abstract::A quantitative analysis using (1)H-NMR (Q-NMR) has been developed for the determination of strychnine and brucine in Strychnos nux-vomica seeds and stems. The advantages of the method are that no reference alkaloids are needed for calibration curves, the quantification could be directly realized on a crude extract, st...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2003-818014
更新日期:2003-12-01 00:00:00
abstract::A beta-hydroxychalcone 1, so far not reported as a natural compound, was separated from the diethyl ether extract of LEPTOSPERMUM SCOPARIUM (Myrtaceae). Furthermore, three known flavonoids 2-4 were isolated. The (13)C-NMR spectra of 2-4 are reported, since they have as yet not been reported in the literature. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-959667
更新日期:1993-06-01 00:00:00
abstract::A lyophilised hydroalcoholic extract of Melissa officinalis L. (Lamiaceae) has been evaluated for behavioral effects in mice. According to the traditional use of M. officinalis, sedative properties have been confirmed for low doses by the decrease of behavioral parameters measured in a non-familiar environment test (s...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-960042
更新日期:1991-04-01 00:00:00
abstract::A series of bitter secoiridoid glucosides isolated from various GENTIANA species (Gentianaceae) have been investigated by D/CI-MS. Amarogentin, amaropanin, amaroswerin, deglucosyltrifloroside, desacetylcentapicrin, gentiopicrin, swertiamarin and sweroside have been characterized by quasimolecular ions and typical frag...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969748
更新日期:1984-10-01 00:00:00
abstract::Praziquantel is the drug of choice for the treatment of schistosomiasis. However, several strains of Schistosoma mansoni are resistant to praziquantel, making it necessary to discover new drugs that might be used for its treatment. With this in mind, the properties of a schistosomicidal ethanolic extract of Garcinia b...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1545927
更新日期:2015-06-01 00:00:00
abstract::The pharmacokinetic profile of arctiin, the major active lignan in fruits of Arctium lappa L., was investigated. Its main meta"bolite arctigenin was identified by an LC-MS method, and an HPLC-UV technique was developed for the simultaneous quantification of the metabolite and arctiin in plasma and organs. Chromatograp...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1298433
更新日期:2012-05-01 00:00:00
abstract::Recently, an increasing number of pharmacists had to supply medicinal products based on Cannabis sativa L. (Cannabaceae), prescribed by physicians to individual patients. Cannabis olive oil preparation is the first choice as a concentrated extract of cannabinoids, even though standardized operative conditions for obta...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0043-123074
更新日期:2018-03-01 00:00:00
abstract::Characterization of an alkali-soluble isolate from Pinus nigra Arnold (Pinaceae) seed cones by thioacidolysis revealed a significant phenylpropanoid (i.c. lignin) component which may provide the observed anti-HIV-1 activity for this substance. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-957801
更新日期:1996-02-01 00:00:00
abstract::An isolated rabbit heart Langendorff preparation paced electrically was used to evaluate the effects of a highly purified, high molecular weight fraction of oligomeric procyanidines isolated from Vitis vinifera seeds on myocardial reperfusion injury after 40 minutes of low flow (1 ml/min) ischemia. Infusion of the hea...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-957956
更新日期:1996-12-01 00:00:00