Quantitative determination of ophiopogonin d by liquid chromatography/electrospray ionization mass spectrometry and its pharmacokinetics in rat.

abstract：:The present study assessed the absolute and relative bioavailabilities of dodeca-2 E,4 E,8 Z,10 E/ Z-tetraenoic acid isobutylamides (tetraenes), the main bioactive constituents in Echinacea, administered as pure compounds or in the form of an Echinacea purpurea root extract preparation. Tetraenes were administered ora...

journal_title：Planta medica

authors： Ardjomand-Woelkart K,Kollroser M,Magnes C,Sinner F,Frye RF,Derendorf H,Bauer R,Butterweck V

更新日期：2011-11-01 00:00:00

abstract：:Human vascular endothelial cells (HUVECs) were exposed to CoCl2 as an in vitro model of hypoxia. Expression of VCAM-1 (vascular cell adhesion molecule), reduction of PECAM-1 (platelet endothelial cell adhesion molecule) and cytoskeletal changes without alterations in cell viability were observed. HUVECs were also expo...

journal_title：Planta medica

authors： Montopoli M,Froldi G,Comelli MC,Prosdocimi M,Caparrotta L

更新日期：2007-03-01 00:00:00

abstract：:A simple and efficient method for the separation of the three phenolic diketones, curcumin 1, demethoxycurcumin 2, and bis-demethoxycurcumin 3, isolated from the rhizomes of Curcuma longa has been developed. The method is of general applicability for the separation of compounds containing acidic and chelating groups a...

journal_title：Planta medica

authors： Rasmussen HB,Christensen SB,Kvist LP,Karazmi A

更新日期：2000-05-01 00:00:00

abstract：:We aimed to find antiallergic agents from natural sources using mast cells activated during allergic reaction. We screened over 2000 plants for blockade of histamine release and identified two of them, S. baicalenesis and P. edulis. Bioassay-guided fractionation led to two main constituent flavonoids, baicalin from S....

journal_title：Planta medica

authors： Kim DS,Son EJ,Kim M,Heo YM,Nam JB,Ro JY,Woo SS

更新日期：2010-05-01 00:00:00

abstract：:The neuroprotective effects of spiramine T, an atisine-type diterpenoid alkaloid isolated from the Chinese herbal medicine Spiraea japonica var. acuta (Rosaceaee), on cerebral ischemia-reperfusion injury produced by 10-min bilateral occlusion of the common carotid arteries followed by 5-day reperfusion in gerbils were...

journal_title：Planta medica

authors： Li L,Nie J,Shen Z,Wu W,Chen Z,Hao X

更新日期：2001-03-01 00:00:00

abstract：:Six pentacyclic triterpenic acid methyl esters have been isolated from the methylated ethyl acetate extract of the trunk wood of MUSANGA CECROPIOIDES, as well as a triterpene saponin of the same group. One of them, cecropic acid methyl ester, is new. The structures of these compounds have been established from interpr...

journal_title：Planta medica

authors： Lontsi D,Sondengam BL,Ayafor JF,Tsoupras MG,Tabacchi R

更新日期：1990-06-01 00:00:00

abstract：:We investigated the apoptotic effects of the protopanaxadiol ginsenosides, Rb (1) and Rb (2), and their intestinal bacterial metabolite, 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol (M1), and of the protopanaxatriol ginsenoside, Rg (1), and its intestinal bacterial metabolite, 20(S)-protopanaxatriol, in activated ...

journal_title：Planta medica

authors： Park EJ,Zhao YZ,Kim J,Sohn DH

更新日期：2006-10-01 00:00:00

abstract：:The distribution and level of yew constituents vary with species and tissues. In this study, a rapid and valid method incorporating ultra-fast liquid chromatography (UFLC) with MS and UV detection was developed for simultaneous determination of paclitaxel and its six semisynthesis precursors in needles and hair roots ...

journal_title：Planta medica

authors： Ge GB,Liang SC,Hu Y,Liu XB,Mao YX,Zhang YY,Luan HW,Qiu MH,Yang L

更新日期：2010-10-01 00:00:00

abstract：:Four p-terphenyl derivatives named curtisians I-L (1-4) were isolated from the MeOH extract of the fruit bodies of Paxillus curtisii. Their structures were elucidated by 2D NMR, MS, IR and UV spectroscopy and chemical reaction. The absolute configurations of curtisians were determined by GC-MS on a chiral column of th...

journal_title：Planta medica

authors： Quang DN,Hashimoto T,Nukada M,Yamamoto I,Tanaka M,Asakawa Y

更新日期：2003-11-01 00:00:00

abstract：:The leaves of Echinodorus grandiflorus are traditionally used in Brazil to treat several inflammatory conditions, including arthritis. This study aimed to investigate the antiarthritis activity of the 70% ethanol extract of E. grandiflorus leaves and a standardized flavonoid-rich fraction in an antigen-induced arthrit...

journal_title：Planta medica

authors： Garcia Ede F,de Oliveira MA,Candido LC,Coelho FM,Costa VV,Queiroz-Junior CM,Boff D,Amaral FA,de Souza Dda G,Teixeira MM,Braga FC

更新日期：2016-03-01 00:00:00

abstract：:Solasodine--a steroid present in the mucilaginous exotesta of the seed in Solanum viarum Dunal (syn. S. khasianum var. chatterjeeanum) is a major source of steroidal raw material. Evidence for the site of solasodine synthesis was sought through reciprocal grafts involving steroid-bearing S. viarum (both diploid and au...

journal_title：Planta medica

authors： Srinivas M,Krishnan R

更新日期：1996-08-01 00:00:00

abstract：:Emodin, chrysophanol and physcion have been shown to be the major anthraquinone pigments present in the dry roots of RUMEX ABYSINICA. ...

journal_title：Planta medica

authors： Munavu RM,Mudamba LO,Ogur JA

更新日期：1984-02-01 00:00:00

abstract：:The solid dispersion of a poorly water-soluble Silybum marianum extract (SME) was prepared by a one-step fluid-bed coating technique depositing onto non-pareil pellets. In vitro evaluation indicated that this technique was highly efficient and reproducible producing pellets with acceptable appearance, flowability, fri...

journal_title：Planta medica

authors： Sun N,Zhang X,Lu Y,Wu W

更新日期：2008-02-01 00:00:00

abstract：:Tryptanthrin and (E,Z)-3-(4-hydroxy-3,5-dimethoxybenzylidene)indolinone (indolinone) were recently isolated from Isatis tinctoria as potent anti-inflammatory and antiallergic alkaloids, and shown to inhibit COX-2, 5-LOX catalyzed leukotriene synthesis, and mast cell degranulation at low µM to nM concentrations. To ass...

journal_title：Planta medica

authors： Jähne EA,Eigenmann DE,Moradi-Afrapoli F,Verjee S,Butterweck V,Hebeisen S,Hettich T,Schlotterbeck G,Smieško M,Hamburger M,Oufir M

更新日期：2016-08-01 00:00:00

abstract：:As a result of the reinvestigation of the alkaloid content of CORYDALIS BULBOSA (L.) DC. (Papaveraceae), growing in Bulgaria, a new 8,11-dioxoaporphine alkaloid, named bulbodione, together with dihydrosanguinarine, dehydroglaucine, (+/-)-sinactine, glaucinone and bicucullinine were isolated. These six alkaloids had no...

journal_title：Planta medica

authors： Kiryakov HG,Iskrenova ES

更新日期：1984-04-01 00:00:00

abstract：:From the rhizome of Zingiber officinale L. (Zingiberaceae), four shogaols that protect IMR32 human neuroblastoma and normal human umbilical vein endothelial cells from beta-amyloid(25 - 35) insult at EC50 = 4.5 - 81 microM were isolated. The efficacy of cell protection from beta-amyloid(25 - 35) insult by these shogao...

journal_title：Planta medica

authors： Kim DS,Kim DS,Oppel MN

更新日期：2002-04-01 00:00:00

abstract：:Anti-sera against a complement-activating pectin (AR-2IIb), which was purified from the roots of Angelica acutiloba Kitagawa, were obtained by immunization of rabbits, and a polyclonal anti-AR-2IIb antibody of the IgG class was purified by affinity chromatography on AR-2IIb-immobilized Sepharose and Protein G-Sepharos...

journal_title：Planta medica

authors： Wang NL,Kiyohara H,Matsumoto T,Otsuka H,Hirano M,Yamada H

更新日期：1994-10-01 00:00:00

abstract：:We have previously shown that 11 ent-kauranes isolated from the stems of Annona squamosa exhibited immunomodulating effects in leukocytes. In this study, a cellular model using isolated human neutrophils, which are important in the pathogenesis of rheumatoid arthritis, ischemia-reperfusion injury, chronic obstructive ...

journal_title：Planta medica

authors： Yeh SH,Chang FR,Wu YC,Yang YL,Zhuo SK,Hwang TL

更新日期：2005-10-01 00:00:00

abstract：:An Alkanna orientalis leaf and flower extract inhibited the growth of Staphylococcus aureus, a pathogen that causes an estimated 478 000 hospitalizations in the US annually. Bioassay-guided fractionation of A. orientalis resulted in isolation of the flavonoid sarothrin (5,7,4'-trihydroxy-3,6,8-trimethoxyflavone), whic...

journal_title：Planta medica

authors： Bame JR,Graf TN,Junio HA,Bussey RO 3rd,Jarmusch SA,El-Elimat T,Falkinham JO 3rd,Oberlies NH,Cech RA,Cech NB

更新日期：2013-03-01 00:00:00

abstract：:Sponges are a useful source of bioactive natural products. Members of the family Mycalidae, in particular, have provided a variety of chemical structures including alkaloids, polyketides, terpene endoperoxides, peptides, and lipids. This review highlights the compounds isolated from Mycalid sponges and their associate...

journal_title：Planta medica

authors： Habener LJ,Hooper JN,Carroll AR

更新日期：2016-06-01 00:00:00

abstract：:To assess possible herb-drug interactions, rutaecarpine (an herbal ingredient of Evodia rutaecarpa; 25 mg/kg/day, p. o.), the ethanol extract of Evodia rutaecarpa (1 g/kg/day, p. o.), and an herbal preparation of Evodia rutaecarpa (Wu-Chu-Yu-Tang; 1 g/kg/day) were individually pretreated daily for three consecutive da...

journal_title：Planta medica

authors： Tsai TH,Chang CH,Lin LC

更新日期：2005-07-01 00:00:00

abstract：:A quantitative analysis using (1)H-NMR (Q-NMR) has been developed for the determination of strychnine and brucine in Strychnos nux-vomica seeds and stems. The advantages of the method are that no reference alkaloids are needed for calibration curves, the quantification could be directly realized on a crude extract, st...

journal_title：Planta medica

authors： Frédérich M,Choi YH,Verpoorte R

更新日期：2003-12-01 00:00:00

abstract：:The antiinflammatory activity of borjatriol (a diterpenoid isolated from SIDERITIS MUGRONENSIS Borja) was tested using the cotton pellet-granuloma assay. The compound inhibited the granuloma weight and the serum lysozyme activity in a dose-dependently way. The determination of this enzyme has allowed us to distinguish...

journal_title：Planta medica

authors： Villar A,Salom R,Alcaraz MJ

更新日期：1984-02-01 00:00:00

abstract：:Variability in the oil content in natural populations of Cymbopogon jawarancusa is discussed. Races rich in piperitone, phellandrene and other chemical constituents have been identified. The oil producing ability was largely genetic and showed heritability of 79.0 percent. ...

journal_title：Planta medica

authors： Dhar AK,Thappa RK,Atal CK

更新日期：1981-04-01 00:00:00

abstract：:Two new phenolic glycosides characterized as idesin salicylate (1) and 2-hydroxyphenol-1-O-beta-D-glucopyranosyl-(6-->1)- alpha-L-rhamnopyranoside (2) were isolated with four known compounds, idescarpin (3), idesin (4), 1-hydroxy-6-oxocyclohex-2-enecarboxylic acid methyl ester (5) and salirepin (6), from the fruits of...

journal_title：Planta medica

authors： Kim SH,Jang YP,Sung SH,Kim YC

更新日期：2007-02-01 00:00:00

abstract：:Infusions of Citrullus colocynthis Schrad. (Cucurbitaceae) fruits are traditionally used as antidiabetic medication in Mediterranean countries, but to our knowledge no studies have been undertaken so far to determine the possible mechanisms involved in the antidiabetic properties of the fruit. The present study was de...

journal_title：Planta medica

authors： Nmila R,Gross R,Rchid H,Roye M,Manteghetti M,Petit P,Tijane M,Ribes G,Sauvaire Y

更新日期：2000-06-01 00:00:00

abstract：:Casearin X (CAS X) is the major clerodane diterpene isolated from the leaves of Casearia sylvestris and has been extensively studied due to its powerful cytotoxic activity at low concentrations. Promising results for in vivo antitumor action have also been described when CAS X was administered intraperitoneally in mic...

journal_title：Planta medica

authors： Moreira da Silva R,de Gaitani CM,Marques LMM,Fraige Baraco K,Cavalheiro AJ,de Moraes LAB,Lopes NP,de Oliveira ARM

更新日期：2019-03-01 00:00:00

abstract：:Three new compounds, namely, (+)-dihydrodehydrodiconiferyl alcohol 4- O- beta-(6''- O-galloyl)-glucopyranoside ( 1), 4,4'- O-dimethylellagic acid 3-(2''- O-acetyl)- alpha-rhamnopyranoside ( 2), and ethyl O- beta-(6'-galloyl)-glucopyranoside ( 3), together with eleven known ones, were isolated from the stem bark of Tre...

journal_title：Planta medica

authors： Kang QJ,Yang XW,Wu SH,Ma YL,Li L,Shen YM

更新日期：2008-03-01 00:00:00

abstract：:Plectranthus barbatus Andr. is one of the most important species of the genus Plectranthus L' Herit. (Lamiaceae), with a wide variety of traditional medicinal uses in Hindu and Ayurvedic traditional medicine as well as in the folk medicine of Brazil, tropical Africa and China. The plant has therefore been an attractiv...

journal_title：Planta medica

authors： Alasbahi RH,Melzig MF

更新日期：2010-05-01 00:00:00

abstract：:A new isoquinoline alkaloid (6), along with nine known ones (1-5, 7-10), was isolated from the plateau plant Corydalis hendersonii, which is used as a traditional Tibetan medicine. The structure of the new compound was elucidated as 9-methyldecumbenine C by spectroscopic evidence. ...

journal_title：Planta medica

authors： Fu Y,Zhou Y,Liao X,Bai B,Peng S,Ding L

更新日期：2009-04-01 00:00:00