Abstract:
:A simple and efficient method for the separation of the three phenolic diketones, curcumin 1, demethoxycurcumin 2, and bis-demethoxycurcumin 3, isolated from the rhizomes of Curcuma longa has been developed. The method is of general applicability for the separation of compounds containing acidic and chelating groups and is amenable to large scale separations. The curcumins 1-3 show moderate activity against Plasmodium falciparum (IC50: 3.5, 4.2 and 3.0 micrograms/ml) and Leishmania major (IC50: 7.8, 14.1 and 21.5 micrograms/ml) respectively.
journal_name
Planta Medjournal_title
Planta medicaauthors
Rasmussen HB,Christensen SB,Kvist LP,Karazmi Adoi
10.1055/s-2000-8533subject
Has Abstractpub_date
2000-05-01 00:00:00pages
396-8issue
4eissn
0032-0943issn
1439-0221journal_volume
66pub_type
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