Hypoglycaemic activity of dioscoretine from tubers of Dioscorea dumetorum in normal and alloxan diabetic rabbits.


:Dioscoretine isolated from the aqueous fraction of the methanol extract of Dioscorea dumetorum tubers when administered intra-peritoneally to normal and alloxan diabetic rabbits produces significant hypoglycaemic effects at a dose of 20 mg/kg. The fasting blood sugar in normoglycaemic rabbits was reduced from 112 mg/100 ml to 55 mg/100 ml after 4 hours. In alloxan diabetic rabbits, the blood sugar was lowered from 520 mg/100 ml to 286 mg/100 ml at the same time interval. The aqueous fraction of the methanol extract produced comparable effects at 100 mg/kg. The chloroform fraction of the same extract raised the fasting blood sugar of normal rabbits to 196 mg/100 ml after 6 h. The acute toxicity studies gave LD50 values of 1.4 g/kg for the aqueous fraction and 0.58 g/kg for dioscoretine when tested on mice. The hypoglycaemic effects were compared to those of tolbutamide.


Planta Med


Planta medica


Iwu MM,Okunji CO,Ohiaeri GO,Akah P,Corley D,Tempesta MS




Has Abstract


1990-06-01 00:00:00












  • Five new compounds from Dendrobium longicornu.

    abstract::A novel bibenzyl, a new bibenzyl, two new phenanthrenes, and a new lignin glycoside, namely longicornuol A (1), 4-[2-(3-hdroxyphenol)-1-methoxyethyl]-2,6-dimethoxyphenol (2), 5-hydroxy-7-methoxy-9,10-dihydrophenanthrene-1,4-dione (3), 7-methoxy-9,10-dihydrophenanthrene-2,4,5-triol (4) and erythro-1-(4-O-beta-D-glucopy...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Hu JM,Chen JJ,Yu H,Zhao YX,Zhou J

    更新日期:2008-04-01 00:00:00

  • Anti HIV-1 flavonoid glycosides from Ochna integerrima.

    abstract::Bioassay-guided fractionation of the anti-HIV-1 active EtOAc extract from leaves and twigs of Ochna integerrima led to the isolation of five new flavonoid glycosides 1 - 5, five known flavonoids 6 - 10, and two known flavonoid glycosides 11 and 12. Structures were determined based on spectroscopic analyses. 6- gamma, ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Reutrakul V,Ningnuek N,Pohmakotr M,Yoosook C,Napaswad C,Kasisit J,Santisuk T,Tuchinda P

    更新日期:2007-06-01 00:00:00

  • Enhanced hypotensive effects of the essential oil of Ocimum gratissimum leaves and its main constituent, eugenol, in DOCA-salt hypertensive conscious rats.

    abstract::The cardiovascular effects of intravenous (i.v.) treatment with the essential oil of Ocimum gratissimum (EOOG) and its main constituent, eugenol (Eug) were investigated in the experimental model of deoxycorticosterone acetate (DOCA-salt)-hypertensive rats. In both conscious DOCA-salt hypertensive rats and their uninep...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Interaminense LF,Leal-Cardoso JH,Magalhães PJ,Duarte GP,Lahlou S

    更新日期:2005-04-01 00:00:00

  • Cyclocariosides II and III: two secodammarane triterpenoid saponins from Cyclocarya paliurus.

    abstract::Two new secodammarane triterpenoid saponins were isolated from the leaves of Cyclocarya paliurus. Based on chemical and spectral analysis they were assigned as (20S)-20-hydroxy-24-O-alpha-L-arabino-pyranosyl-3,4- secodammar-4(28),11,25-trien-3-oic acid, named cyclocarioside II and 25-hydroxy-(20S,24R)-epoxy-12R-O-beta...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Shu RG,Xu CR,Li LN,Yu ZL

    更新日期:1995-12-01 00:00:00

  • A comparative study on commercial samples of ginseng radix.

    abstract::A total of 37 commercial samples of Ginseng Radix, the origins of which belonged to Panax ginseng C. A. Meyer, P. quinquefolia Linn. (American ginseng), and P. notoginseng Burkill (sanchi-ginseng), respectively, were collected from the Taiwan herbal markets. The contents of nine ginsenosides, Rb(1), Rb(2), Rc, Rd, Re,...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Chuang WC,Wu HK,Sheu SJ,Chiou SH,Chang HC,Chen YP

    更新日期:1995-10-01 00:00:00

  • Inhibition of low density lipoprotein oxidation by tetrahydrofurofuran lignans from Forsythia suspensa and Magnolia coco.

    abstract::Based on the inhibition of Cu(2+)-induced LDL oxidation as marker, the major antioxidants in the fruits of Forsythia suspensa and the stems of Magnolia coco were identified. Of these bioactive tetrahydrofurofuran lignans, pinoresinol, phillygenin, and syringaresinol were more potent than probucol. Sesamin and fargesin...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Chen CC,Chen HY,Shiao MS,Lin YL,Kuo YH,Ou JC

    更新日期:1999-12-01 00:00:00

  • Inhibition of VHR dual-specificity protein tyrosine phosphatase activity by flavonoids isolated from Scutellaria baicalensis: structure-activity relationships.

    abstract::Three flavonoids: norwogonin, dihydronorwogonin and baicalein, were isolated from the roots of Scutellaria baicalensis, as potential inhibitors of VHR dual-specificity protein tyrosine phosphatase (DS-PTPase). Norwogonin (IC 50 = 1.1 microM), dihydronorwogonin (IC 50 = 2.9 microM) and baicalein (IC 50 = 2.4 microM) sh...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Lee MS,Oh WK,Kim BY,Ahn SC,Kang DO,Sohn CB,Osada H,Ahn JS

    更新日期:2002-12-01 00:00:00

  • A new alkaloid from Corydalis hendersonii.

    abstract::A new isoquinoline alkaloid (6), along with nine known ones (1-5, 7-10), was isolated from the plateau plant Corydalis hendersonii, which is used as a traditional Tibetan medicine. The structure of the new compound was elucidated as 9-methyldecumbenine C by spectroscopic evidence. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Fu Y,Zhou Y,Liao X,Bai B,Peng S,Ding L

    更新日期:2009-04-01 00:00:00

  • An arabinogalactan-protein from cell culture of Malva sylvestris.

    abstract::An arabinogalactan-protein (AGP) from suspension culture medium of Malva sylvestris was isolated by precipitation with beta-glucosyl Yariv reagent, followed by gel-permeation chromatography. It revealed characteristic features of AGPs: a high amount of polysaccharide with a ratio of galactose to arabinose of 1.9 : 1, ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Classen B,Blaschek W

    更新日期:2002-03-01 00:00:00

  • Effects of the olive tree leaf constituents on myocardial oxidative damage and atherosclerosis.

    abstract::The olive (Olea europaea) leaf is considered an important traditional herbal medicine utilized against infectious diseases, and for the treatment of diabetes and hypertension. Moreover, olive leaf constituents have been related to cardioprotection, probably due to their association with cellular redox modulating effec...

    journal_title:Planta medica

    pub_type: 杂志文章,评审


    authors: Efentakis P,Iliodromitis EK,Mikros E,Papachristodoulou A,Dagres N,Skaltsounis AL,Andreadou I

    更新日期:2015-06-01 00:00:00

  • Inhibitory effect of tumor cell proliferation and induction of G2/M cell cycle arrest by panaxytriol.

    abstract::Panaxytriol, a polyacetylenic compound, isolated from red ginseng (Panax ginseng C.A. Meyer), was studied to determine its effects on the growth and cell cycle of tumor cell lines. The compound showed both significant cytotoxicity and inhibition of DNA syntheses in various tumor cells tested. For P388D1, a mouse lymph...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Kim JY,Lee KW,Kim SH,Wee JJ,Kim YS,Lee HJ

    更新日期:2002-02-01 00:00:00

  • Possible active components of tan-shen (Salvia miltiorrhiza) for protection of the myocardium against ischemia-induced derangements.

    abstract::Extract of Tan-Shen (Salvia miltiorrhiza, Labiatae), a Chinese traditional crude drug, was reported to show beneficial activity for heart disease. Chemical examination on the extract was performed on the basis of screening for protective action on the ischemic myocardium. Isolated hearts were subjected to hypoxic perf...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Yagi A,Fujimoto K,Tanonaka K,Hirai K,Takeo S

    更新日期:1989-02-01 00:00:00

  • Sonoran propolis and some of its chemical constituents inhibit in vitro growth of Giardia lamblia trophozoites.

    abstract::Propolis is a cereus resin with a complex chemical composition that possesses a wide range of biological activities. The aim of this study was to evaluate the in vitro anti-Giardia lamblia activity of Sonoran propolis collected from three different areas of Sonoran Desert in northwestern Mexico (Caborca, Pueblo de Ala...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Alday-Provencio S,Diaz G,Rascon L,Quintero J,Alday E,Robles-Zepeda R,Garibay-Escobar A,Astiazaran H,Hernandez J,Velazquez C

    更新日期:2015-06-01 00:00:00

  • Protective Effects of α-Boswellic Acids in a Pulmonary Arterial Hypertensive Rat Model.

    abstract::The purpose of this study was to observe the protective effects of α-boswellic acids on hypoxia-induced pulmonary vascular structural remodeling in pulmonary arterial smooth muscle cells in a hypertensive rat model. Pulmonary arterial smooth muscle cells were cultured and then randomly divided into four groups: normox...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Xiao B,Zhang G,Ali Sheikh MS,Shi R

    更新日期:2017-01-01 00:00:00

  • NIR Spectroscopy of Actaea racemosa L. rhizome - En Route to Fast and Low-Cost Quality Assessment.

    abstract::Rhizomes of Actaea racemosa L. (formerly Cimicifuga racemosa) gained increasing interest as a plant-derived drug due to its hormone-like activity and the absence of estrogenic activity. According to the Current Good Manufacturing Practices guidelines and pharmacopeial standards, quality assessment of herbal starting m...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Bittner M,Krähmer A,Schenk R,Springer A,Gudi G,Melzig MF

    更新日期:2017-08-01 00:00:00

  • [Determination of structures by H NMR at 400 MHz: albifloranine, a new alkaloid from Tabernaemontana albiflora].

    abstract::The structure of albifloranine 1, a new alkaloid of ibogane type from the stem bark of Tabernaemontana albiflora (M IQ.) Pull. (Apocynaceae) has been determined. A detailed (1)H NMR study of albifloranine 1, coronaridine 2 and heyneanine 3 is presented. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Kan C,Husson HP,Kan SK,Lounasmaa M

    更新日期:1981-01-01 00:00:00

  • Inhibition of the transcription factor NF-kappa B by sesquiterpene lactones from Podachaenium eminens.

    abstract::Investigation of Podachaenium eminens afforded nine sesquiterpene lactones (Sls) from which costunolide, 7-hydroxycostunolide, santamarin as well as 3-chlorodehydroleucodin are new for this plant and 3,4-dehydro-4-dehydroxypodachaenin (= 3-costoyloxydehydroleucodin) is found for the first time in nature. All isolated ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Castro V,Murillo R,Klaas CA,Meunier C,Mora G,Pahl HL,Merfort I

    更新日期:2000-10-01 00:00:00

  • Erythrinaline alkaloids and antimicrobial flavonoids from Erythrina latissima.

    abstract::The seed pods of Erythrina latissima yielded erysotrine, erysodine, syringaresinol, vanillic acid, a new erythrina alkaloid, (+)-10,11-dioxoerysotrine, which was lethal to brine shrimp and 2-(5'-hydroxy-3'-methoxy phenyl)-6-hydroxy-5-methoxybenzofuran, which showed strong antimicrobial activity against the yeast spore...

    journal_title:Planta medica

    pub_type: 信件


    authors: Wanjala CC,Juma BF,Bojase G,Gashe BA,Majinda RR

    更新日期:2002-07-01 00:00:00

  • Improved method for the determination of oxindole alkaloids in Uncaria tomentosa by high performance liquid chromatography.

    abstract::This Paper describes an improved HPLC method for the determination of pentacyclic oxindole alkaloids in Uncaria tomentosa (Cat's Claw). Six of the isomeric compounds could be baseline separated at room temperature within less than 30 min by using 3 microm C-18 column material and a mobile phase consisting of 10 mM pho...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Ganzera M,Muhammad I,Khan RA,Khan IA

    更新日期:2001-07-01 00:00:00

  • Antimycobacterial Activity of Alkaloids and Extracts from Tabernaemontana alba and T. arborea.

    abstract::Tuberculosis is the main cause of death from a single infectious agent. Globally, according to the World Health Organization, in 2018, there were an estimated 1.2 million tuberculosis deaths. Moreover, there is a continuous appearance of drug-resistant strains. Thus, development of new antituberculosis medicines shoul...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Guzmán-Gutiérrez SL,Silva-Miranda M,Krengel F,Huerta-Salazar E,León-Santiago M,Díaz-Cantón JK,Espitia Pinzón C,Reyes-Chilpa R

    更新日期:2020-05-11 00:00:00

  • Mechanism of inhibition of peroxynitrite-induced oxidation and nitration by [6]-gingerol.

    abstract::[6]-Gingerol potently inhibits peroxynitrite-induced oxidation and nitration reactions, but its mechanism of action is unclear. In order to discover the mechanism of inhibition, [6]-gingerol was reacted with peroxynitrite and the reaction mixture was analyzed using HPLC. The HPLC chromatogram showed one novel peak, in...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Ippoushi K,Ito H,Horie H,Azuma K

    更新日期:2005-06-01 00:00:00

  • Development of in vitro techniques for the important medicinal plant Veratrum californicum.

    abstract::VERATRUM CALIFORNICUM (Liliaceae) is an important monocotyledonous medicinal plant which is the only source of the anticancer compound cyclopamine. An IN VITRO culture system for somatic embryogenesis and green plant regeneration of VERATRUM CALIFORNICUM was developed. Embryogenic calli were induced from mature embryo...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Ma R,Ritala A,Oksman-Caldentey KM,Rischer H

    更新日期:2006-10-01 00:00:00

  • Phthalides in the essential oil from roots of Levisticum officinale.

    abstract::The composition of the phthalide mixture of the essential oil from roots of Levisticum officinale Koch was investigated. The phthalide mixture was analyzed by combining separation methods - GLC, LSC and TLC - and subsequently using spectroscopic methods - IR, MS and NMR. E- and Z-butylidenephthalide, E- and Z-ligustil...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Gijbels MJ,Scheffer JJ,Baerheim Svendsen A

    更新日期:1982-04-01 00:00:00

  • Dodonic Acid, A New Diterpenoid from Dodonaea viscosa1.

    abstract::The aerial parts of DODONAEA VISCOSA afforded a new diterpenoid, dodonic acid, the structure and stereochemistry of which have been established by chemical and spectroscopic means. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Sachdev K,Kulshreshtha DK

    更新日期:1984-10-01 00:00:00

  • Taspine is the cicatrizant principle in Sangre de Grado extracted from Croton lechleri.

    abstract::Sangre de Grado extract used by Peruvian natives as a cicatrizant agent, was collected from trees of the species Croton lechleri growing in the Peruvian jungle. The Sangre de Grado was found to contain one alkaloid identified as taspine and which was shown to be the active cicatrizant principle by an in vivo test in m...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Vaisberg AJ,Milla M,Planas MC,Cordova JL,de Agusti ER,Ferreyra R,Mustiga MC,Carlin L,Hammond GB

    更新日期:1989-04-01 00:00:00

  • [Apoptosis-inducing properties of ent-kaurene-type diterpenoids from the liverwort Jungermannia truncata].

    abstract::Ent-11alpha-hydroxy-16-kauren-15-one (1) induced apoptosis in a human leukemia cell line (HL-60 cells), however, the apoptosis-inducing properties of 1 and its related compounds remain to be proved. We examined the involvement of caspases, a family of cysteine aspartic proteases, which play a central role in induction...

    journal_title:Planta medica

    pub_type: 信件


    authors: Nagashima F,Kondoh M,Kawase M,Simizu S,Osada H,Fujii M,Watanabe Y,Sato M,Asakawa Y

    更新日期:2003-04-01 00:00:00

  • A new epoxyflavanone from tephrosia hamiltonii1.

    abstract::A phytochemical study of the whole plant of TEPHROSIA HAMILTONII afforded a new flavonoid, characterised as 5, 7-dimethoxy-8-(2, 3-epoxy-3-methylbutyl)-flavanone, along with other known compounds. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Falak AH,Shoeb A

    更新日期:1987-04-01 00:00:00

  • [Barbatoside, a new Iridoid glucoside from Penstemon barbatus].

    abstract::From leaves of Penstemon barbatus Nutt. a new iridoid glucoside has been isolated. The structure was established mainly by spectroscopic methods ( (1)H-NMR, (13)C-NMR, IR, MS). ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Junior P

    更新日期:1982-06-01 00:00:00

  • Isolation of two triterpenoids and a biflavanone with anti-Inflammatory activity from Schinus molle fruits.

    abstract::Three compounds with anti-inflammatory activity were isolated from Schinus molle fruits. Two of the compounds were identified as 3- epi-isomasticadienolalic acid ( 1), isomasticadienonalic acid ( 2) and chamaejasmin ( 3). Triterpenes 1 and 2, and biflavanone 3 were tested on two models of mice paw inflammation: one of...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Yueqin Z,Recio MC,Máñez S,Giner RM,Cerdá-Nicolás M,Ríos JL

    更新日期:2003-10-01 00:00:00

  • Antioxidant and lipophilic constituents of Tinospora crispa.

    abstract::TLC autographic assays revealed in the CH(2)Cl(2) extract of Tinospora crispa Miers (Menispermaceae) the presence of three compounds exhibiting antioxidant and radical scavenging properties towards beta-carotene and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. They were isolated and identified as N-CIS-feruloyltyrami...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Cavin A,Hostettmann K,Dyatmyko W,Potterat O

    更新日期:1998-06-01 00:00:00