Abstract:
:The crude methanol extract of the Kenyan shrub Leucas volkensii Gürke (Labiatae) displayed in a radiorespirometric bioassay antimycobacterial activity against Mycobacterium tuberculosis. Bioassay-guided fractionation of the crude extract led to the identification of (E)-phytol as the principal active component with a minimum inhibitory concentration (MIC) of 2 micrograms/ml, a value also observed for (3R,S,7R,11R)-phytanol, (Z)-phytol, and a commercially available 2:1 mixture of (E)- and (Z)-phytol. The derivatives (E)-phytol acetate, a mixture of the (2S,3S)- and (2R,3R)-isomers of (E)-phytol epoxide and (3R,S,7R,11R)-phytanic acid displayed lower activities with MICs of 8, 16, and > 128 micrograms/ml, respectively. Geraniol and farnesol, displayed MICs of 64 and 8 micrograms/ml, respectively. The activities of (E)-phytol, (Z)-phytol and (3R,S,7R,11R)-phytanol were found to be in the same range as ethambutol, a clinically useful drug with an MIC in the range 0.95-3.8 micrograms/ml.
journal_name
Planta Medjournal_title
Planta medicaauthors
Rajab MS,Cantrell CL,Franzblau SG,Fischer NHdoi
10.1055/s-2006-957354subject
Has Abstractpub_date
1998-02-01 00:00:00pages
2-4issue
1eissn
0032-0943issn
1439-0221journal_volume
64pub_type
杂志文章相关文献
PLANTA MEDICA文献大全abstract::Valeriana officinalis L. is a popular herbal treatment for mild sleep disorders. Clinical and non-clinical studies found contradictory results for valerian extracts and single constituents regarding the influence on sleep parameters. It was the aim of this study to investigate the sedative effects of a valerian root e...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0030-1250589
更新日期:2011-05-01 00:00:00
abstract::In order to evaluate the potency of novel antiviral drugs, 11 natural sulfated polysaccharides (SPs) from 10 green algae ( Enteromorpha compressa, Monostroma nitidum, Caulerpa brachypus, C. okamurai, C. scapelliformis, Chaetomorpha crassa, C. spiralis, Codium adhaerens, C. fragille, and C. latum) and 4 synthetic sulfa...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2004-827228
更新日期:2004-09-01 00:00:00
abstract::Bioassay directed fractionation of the (1:1) chloroform-methanol extract of Gentiana spathacea H.B.K (Gentianaceae) led to the isolation of gentiopicroside (gentiopricrin) (1), the major spasmolytic component of the plant. Gentiopicroside inhibited, in a concentration-dependent manner, the spontaneous contractions of ...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2000-9774
更新日期:2000-12-01 00:00:00
abstract::Cannabis (Cannabis sativa L.) is an annual herbaceous plant that belongs to the family Cannabaceae. Trans-Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) are the two major phytocannabinoids accounting for over 40% of the cannabis plant extracts, depending on the variety. At the University of Mississippi, differ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0043-124088
更新日期:2018-03-01 00:00:00
abstract::Ulcerative colitis is a chronic inflammatory condition whose treatment includes aminosalicylates, corticosteroids, and immunomodulators. Medicinal plants seem to be an important alternative treatment for this condition. They have been the subject of a great number of studies in recent years. This study was conducted t...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-0043-104933
更新日期:2017-05-01 00:00:00
abstract::The formation of lactonic amines 3 and 4 from alpha-methylene-gamma-butyrolactone (tulipalin A) 1 is described. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969585
更新日期:1985-12-01 00:00:00
abstract::Despite the huge diversity of antibacterial compounds, bacterial resistance to first-choice antibiotics has been drastically increasing. Moreover, the association between multiresistant microorganisms and nosocomial infections highlight the problem, and the urgent need for solutions. Natural resources have been exploi...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-0032-1315370
更新日期:2012-11-01 00:00:00
abstract::The anti-inflammatory activity of alpha-viniferin, a trimer of resveratrol, has been demonstrated in an animal model of carrageenin-induced paw edema, and inhibitory effects of the compound on cyclooxygenase (COX) and inducible nitric oxide synthase (iNOS) have been investigated in order to understand the mode of the ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2003-42787
更新日期:2003-08-01 00:00:00
abstract::Five new xanthone glycosides, comastomasides A-E (1-5), were isolated from aqueous ethanol extracts of the aerial portions of Comastoma pedunculatum. The structures of these compounds were elucidated by spectroscopic analysis methods. Compounds 1-5 were evaluated for their hepatoprotective activity and cytotoxicity ag...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1315079
更新日期:2012-09-01 00:00:00
abstract::From an extract of the whole plant of Ligularia virgaurea ssp. oligocephala, three new eremophilane sesquiterpene lactones, 10alpha-hydroxy-1-oxoeremophila-7(11),8(9)-dien-12,8-olide (1), 6alpha,10alpha-dihydroxy-1-oxoeremophila-7(11),8(9)-dien-12,8-olide (2), 6beta,10beta-dihydroxyeremophila-7(11),8(9)-dien-12,8-olid...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2004-818983
更新日期:2004-05-01 00:00:00
abstract::A museum collection of Cinchonae cortex samples (n = 117), from the period 1850-1950, was extracted with a mixture of chloroform-d1, methanol-d4, water-d2, and perchloric acid in the ratios 5 : 5 : 1 : 1. The extracts were directly analyzed using 1H NMR spectroscopy (600 MHz) and the spectra evaluated using principal ...
journal_title:Planta medica
pub_type: 历史文章,杂志文章
doi:10.1055/s-0032-1315396
更新日期:2012-11-01 00:00:00
abstract::The dietary intake of flavonoids seems to be inversely related to cardiovascular mortality. The consumption of isoflavonoids is increasing in the general population, especially due to the use of food supplements and a variety of isoflavonoid-rich foods. However, detailed studies on the vascular influence of individual...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/a-1158-9422
更新日期:2020-07-01 00:00:00
abstract::A lyophilised hydroalcoholic extract of Melissa officinalis L. (Lamiaceae) has been evaluated for behavioral effects in mice. According to the traditional use of M. officinalis, sedative properties have been confirmed for low doses by the decrease of behavioral parameters measured in a non-familiar environment test (s...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-960042
更新日期:1991-04-01 00:00:00
abstract::The therapy of type-2 diabetes mellitus is one of the major challenges of our age. A possible strategy to prevent the progression of this disease is the inhibition of protein tyrosine phosphatase 1B (PTP1B), a major negative regulator in the insulin and leptin signalling pathway. Phellodendri amurensis cortex is a wel...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1280377
更新日期:2012-02-01 00:00:00
abstract::Rutaecarpine is an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa. Recently, rutaecarpine has been characterized to have an anti-inflammatory activity through cyclooxygenase-2 inhibition. In the present studies, the effects of rutaecarpine on liver cytochrome P450 s (P450s) and P450 s involved...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2004-827207
更新日期:2004-08-01 00:00:00
abstract::Evidence supports the theory that bacterial communities colonizing Echinacea purpurea contribute to the innate immune enhancing activity of this botanical. Previously, we reported that only about half of the variation in in vitro monocyte stimulating activity exhibited by E. purpurea extracts could be accounted for by...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-108590
更新日期:2016-09-01 00:00:00
abstract::Amphotericin B (AmB) is a representative antibiotic for the control of serious fungal infections, and its fungicidal activity was greatly enhanced by allicin, an allyl-sulfur compound from garlic. In addition to the plasma membrane permeability change, AmB induced vacuole membrane damage so that the organelles were vi...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-947203
更新日期:2006-10-01 00:00:00
abstract::A systematic structure-activity relationship of 3beta-hydroxy-27- P- E-coumaroyloxyurs-12-en-28-oic acid ( 7), a triterpene ester isolated from UNCARIA RHYNCHOPHYLLA as a phospholipase Cgamma1 inhibitor, was undertaken with a view toward elucidating its chemical mode of action on PLCgamma1. Related derivatives and ana...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2008-1081348
更新日期:2008-10-01 00:00:00
abstract::Acute myocardial infarction (AMI) remains the leading cause of mortality in the world. Early intervention using salvianolic acids (SA) can substantially improve clinical outcomes. However, in spite of the great achievements that have been made in elucidating the protective effects of SA on AMI, the effects of SA on th...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0029-1185669
更新日期:2009-10-01 00:00:00
abstract::In this study the skin permeation and the topical anti-inflammatory properties of ginger extracts were investigated. A commercial ginger dry extract (DE) and a gingerols-enriched dry extract (EDE) were evaluated for their in vivo topical anti-inflammatory activity by inhibition of Croton oil-induced ear oedema in mice...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-993741
更新日期:2007-12-01 00:00:00
abstract::High molecular compounds from Chinese herbal medicines, including ribosome-inactivating proteins and polysaccharides from both fungi and high plants have been tested for the treatment of malignant diseases. Polysaccharides possessing immunostimulating activities can be used as adjuvants in tumor treatment. The fungi c...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-2003-38494
更新日期:2003-03-01 00:00:00
abstract::The anti-inflammatory effects of boldine and reticuline isolated from Litsea cubeba were evaluated by using xylene-induced ear edema and carrageenan-induced paw edema in mice and rats. Our results demonstrated that intragastric administration with boldine and reticuline significantly mitigated ear weight in mice and d...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0043-113447
更新日期:2018-01-01 00:00:00
abstract::One new drimane-type sesquiterpenoid, 3 β-angeloyloxy-7-epifutronolide (1), and one new natural product, polygonumate (2), along with six known drimane-type sesquiterpenes [dendocarbin L (3), (+) winterin (4), (+) fuegin (5), changweikangic acid A (6), futronolide (7), and 7-ketoisodrimenin (8)] were isolated from the...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0030-1271178
更新日期:2011-11-01 00:00:00
abstract::Picroliv, a standardized extract from the plant Picrorhiza kurrooa containing active constituents, showed a significant dose dependent (3-12 mg/kg p.o. x 7) protective activity against galactosamine-induced hepatic damage in rat as evaluated on the isolated hepatocytes (ex vivo) preparation. It markedly increased the ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-959600
更新日期:1993-02-01 00:00:00
abstract::In our ongoing efforts to identify effective naturally sourced agents for the treating of diabetic complications, two new (1 and 2) and 11 known phenolic compounds (3-13) were isolated from an 80 % ethanol extract of Litsea japonica leaves. The structures of the new compounds were established by spectroscopic and chem...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-116324
更新日期:2017-02-01 00:00:00
abstract::The indole alkaloid content of RAUWOLFIA SERPENTINA roots from regenerated plants (from stem-and root-callus) was compared with the parental stock. Although the total alkaloid content seems to be slightly higher in the roots from regenerated plants, HPLC-analysis of individual alkaloids indicated that the contents of ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-960109
更新日期:1991-08-01 00:00:00
abstract::Seven new clerodane diterpenoids, dysoxydensins A-G (1-7), together with six known clerodanes, were isolated from Dysoxylum densiflorum. The structures of all the compounds were elucidated by extensive spectroscopic analysis. These compounds were evaluated for their cytotoxic activities against five human cancer cell ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0034-1382903
更新日期:2014-08-01 00:00:00
abstract::The present study was designed to investigate the mechanism of action of n-butylidenephthalide on the deficits of inhibitory avoidance performance induced by drugs in rats with piracetam as a positive control. n-Butylidenephthalide attenuated the scopolamine-induced and mecamylamine-induced acquisition impairment, and...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2001-10631
更新日期:2001-02-01 00:00:00
abstract::Myrrh is the oleo-gum resin of mainly Commiphora molmol and as a powdered substance, one compound in the traditional medicinal product Myrrhinil-Intest®, which has been used for the treatment of unspecific, inflammatory intestinal disorders. The aim of the present study was to evaluate the antispasmodic effect of myrr...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0034-1383391
更新日期:2015-01-01 00:00:00
abstract::Three new glycosides, 1,4,8-trihydroxynaphthalene-1-O-D-glucopyranosyl-(1-->6)-beta-D- xylopyranoside (1), 1,4,8-trihydroxynaphthalene-1-O-beta-D-glucopyranosyl-(1-->6)-alph a-L- arabinopyranoside (2), 1-hydroxy-4-methoxynaphthalene-1-O-beta-D-glucopyranosyl-(1-->6)- alpha-L-rhamnopyranoside (3), were isolated from th...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-0029-1243129
更新日期:2000-03-01 00:00:00