Abstract:
:Amphotericin B (AmB) is a representative antibiotic for the control of serious fungal infections, and its fungicidal activity was greatly enhanced by allicin, an allyl-sulfur compound from garlic. In addition to the plasma membrane permeability change, AmB induced vacuole membrane damage so that the organelles were visible as small discrete particles. Although allicin was ineffective in promoting AmB-induced plasma membrane disability, this compound enhanced AmB-induced structural damage to the vacuolar membrane even at a non-lethal dose of the antibiotic. Allicin could also enhance the antifungal activity of AmB against the pathogenic fungus Candida albicans and against Aspergillus fumigatus. In contrast, allicin did not enhance the cytotoxic activity of AmB against cells of human promyelocytic leukemia (HL-60), a vacuole-less organism.
journal_name
Planta Medjournal_title
Planta medicaauthors
Ogita A,Fujita K,Taniguchi M,Tanaka Tdoi
10.1055/s-2006-947203subject
Has Abstractpub_date
2006-10-01 00:00:00pages
1247-50issue
13eissn
0032-0943issn
1439-0221journal_volume
72pub_type
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