Abstract:
:Picroliv, a standardized extract from the plant Picrorhiza kurrooa containing active constituents, showed a significant dose dependent (3-12 mg/kg p.o. x 7) protective activity against galactosamine-induced hepatic damage in rat as evaluated on the isolated hepatocytes (ex vivo) preparation. It markedly increased the percentage of viability of hepatocytes. It also restored the galactosamine-induced changes in the levels of enzymes (GOT, GPT and alkaline phosphatase) both in isolated hepatic cells as well as in serum. In addition, picroliv possessed a marked anticholestatic effect. Picroliv was found to be more potent than silymarin, a standard hepatoprotective agent.
journal_name
Planta Medjournal_title
Planta medicaauthors
Visen PK,Shukla B,Patnaik GK,Dhawan BNdoi
10.1055/s-2006-959600subject
Has Abstractpub_date
1993-02-01 00:00:00pages
37-41issue
1eissn
0032-0943issn
1439-0221journal_volume
59pub_type
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