Reversal caused by n-butylidenephthalide from the deficits of inhibitory avoidance performance in rats.

Abstract:

:The present study was designed to investigate the mechanism of action of n-butylidenephthalide on the deficits of inhibitory avoidance performance induced by drugs in rats with piracetam as a positive control. n-Butylidenephthalide attenuated the scopolamine-induced and mecamylamine-induced acquisition impairment, and also attenuated the acquisition impairment induced by scopolamine plus mecamylamine. Furthermore, scopolamine methylbromide, a peripheral cholinergic muscarinic receptor antagonist, did not block the counteracting effect of n-butylidenephthalide on the scopolamine-induced acquisition impairment. n-Butylidenephthalide attenuated the impairment of inhibitory avoidance performance induced by the central acetylcholinergic neurotoxin AF64A administered intracisternally. From the above results, we suggest that n-butylidenephthalide attenuated the deficits of inhibitory avoidance performance induced by drugs, which are the effects related to activating the central but not the peripheral cholinergic neuronal system via muscarinic and nicotinic receptors.

journal_name

Planta Med

journal_title

Planta medica

authors

Hsieh MT,Wu CR,Lin LW,Hsieh CC,Tsai CH

doi

10.1055/s-2001-10631

subject

Has Abstract

pub_date

2001-02-01 00:00:00

pages

38-42

issue

1

eissn

0032-0943

issn

1439-0221

journal_volume

67

pub_type

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