Abstract:
:An antimicrobial diterpene was isolated from Alpinia galanga in the screening for potentiators of phytochemical antibiotic action. The structure was elucidated by spectral data and identified as (E)-8 beta, 17-epoxylabd-12-ene-15, 16-dial (1). Diterpene 1 synergistically enhanced the antifungal activity of quercetin and chalcone against Candida albicans. Antifungal activity of 1 was reversed by unsaturated fatty acids. Protoplasts of C. albicans were lysed by 1. These results suggest that antifungal activity of 1 is due to a change of membrane permeability arising from membrane lipid alternation.
journal_name
Planta Medjournal_title
Planta medicaauthors
Haraguchi H,Kuwata Y,Inada K,Shingu K,Miyahara K,Nagao M,Yagi Adoi
10.1055/s-2006-957890subject
Has Abstractpub_date
1996-08-01 00:00:00pages
308-13issue
4eissn
0032-0943issn
1439-0221journal_volume
62pub_type
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