Antifungal activity from Alpinia galanga and the competition for incorporation of unsaturated fatty acids in cell growth.

Abstract:

:An antimicrobial diterpene was isolated from Alpinia galanga in the screening for potentiators of phytochemical antibiotic action. The structure was elucidated by spectral data and identified as (E)-8 beta, 17-epoxylabd-12-ene-15, 16-dial (1). Diterpene 1 synergistically enhanced the antifungal activity of quercetin and chalcone against Candida albicans. Antifungal activity of 1 was reversed by unsaturated fatty acids. Protoplasts of C. albicans were lysed by 1. These results suggest that antifungal activity of 1 is due to a change of membrane permeability arising from membrane lipid alternation.

journal_name

Planta Med

journal_title

Planta medica

authors

Haraguchi H,Kuwata Y,Inada K,Shingu K,Miyahara K,Nagao M,Yagi A

doi

10.1055/s-2006-957890

subject

Has Abstract

pub_date

1996-08-01 00:00:00

pages

308-13

issue

4

eissn

0032-0943

issn

1439-0221

journal_volume

62

pub_type

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