Abstract:
:A methanolic extract of Commelina communis showed potent inhibitory activity against alpha-glucosidase. One pyrrolidine alkaloid, 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine (DMDP, 1) and four piperidine alkaloids, 1-deoxymannojirimycin (2), 1-deoxynojirimycin (3), alpha-homonojirimycin (4) and 7-O-beta-D-glucopyranosyl alpha-homonojirimycin (5) were isolated by bioassay-directed fractionation and separation. These compounds have been identified for the first time from Commelina communis, supporting the pharmacological basis of this plant that has been used as a traditional herbal medicine for the treatment of diabetes.
journal_name
Planta Medjournal_title
Planta medicaauthors
Kim HS,Kim YH,Hong YS,Paek NS,Lee HS,Kim TH,Kim KW,Lee JJdoi
10.1055/s-2006-960803subject
Has Abstractpub_date
1999-06-01 00:00:00pages
437-9issue
5eissn
0032-0943issn
1439-0221journal_volume
65pub_type
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