Nematicidal activities of two phytoalexins from Taverniera abyssinica.

Abstract:

:The traditional analgesic and antipyretic Ethiopian drug "Dingetegna" is made of dried root material of Taverniera abyssinica A. Rich (Leguminosae). In a screening for nematicidal natural products, "Dingetegna" extracts showed strong nematicidal activities towards C. elegans. In the following, medicarpin and 4-hydroxymedicarpin were isolated as nematicidal constituents from the extracts. In a microwell plate assay for nematicidal activity, both compounds exhibited an LD50 of 25 micrograms/ml towards C. elegans. Beside these nematicidal effects, weak cytotoxic and antimicrobial activities were observed. In addition, both compounds inhibited oxygen consumption of axenically grown C. elegans, L 1210 cells, and filamentous fungi. Respiration in sensitive bacteria was not affected. In L 1210 cells, the incorporation of precursors into macromolecules was affected in the presence of glucose, indicating that inhibition of respiration is not the only target site of the compounds.

journal_name

Planta Med

journal_title

Planta medica

authors

Stadler M,Dagne E,Anke H

doi

10.1055/s-2006-959569

subject

Has Abstract

pub_date

1994-12-01 00:00:00

pages

550-2

issue

6

eissn

0032-0943

issn

1439-0221

journal_volume

60

pub_type

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