Abstract:
:Human vascular endothelial cells (HUVECs) were exposed to CoCl2 as an in vitro model of hypoxia. Expression of VCAM-1 (vascular cell adhesion molecule), reduction of PECAM-1 (platelet endothelial cell adhesion molecule) and cytoskeletal changes without alterations in cell viability were observed. HUVECs were also exposed to Escherichia coli lipopolysaccaride (LPS) as an in vitro model of inflammation: significant IL-6 release was measured. Pre-treatment of HUVECs with aescin prevented, in a concentration-dependent fashion (0.1-1 microM), the action of CoCl2 on VCAM-1 and PECAM-1, also preserving endothelial cell morphology. Furthermore, aescin pre-treatment reduced IL-6 release from LPS-activated vascular endothelium.
journal_name
Planta Medjournal_title
Planta medicaauthors
Montopoli M,Froldi G,Comelli MC,Prosdocimi M,Caparrotta Ldoi
10.1055/s-2007-967118subject
Has Abstractpub_date
2007-03-01 00:00:00pages
285-8issue
3eissn
0032-0943issn
1439-0221journal_volume
73pub_type
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