Inhibition of human immunodeficiency virus type 1 reverse transcriptase activity by cordatolides isolated from Calophyllum cordato-oblongum.

abstract：:Two new phenolic glycosides characterized as idesin salicylate (1) and 2-hydroxyphenol-1-O-beta-D-glucopyranosyl-(6-->1)- alpha-L-rhamnopyranoside (2) were isolated with four known compounds, idescarpin (3), idesin (4), 1-hydroxy-6-oxocyclohex-2-enecarboxylic acid methyl ester (5) and salirepin (6), from the fruits of...

journal_title：Planta medica

authors： Kim SH,Jang YP,Sung SH,Kim YC

更新日期：2007-02-01 00:00:00

abstract：:Volatile constituents of the essential oils from leaves and inflorescences of Solidago chilensis Meyen were analyzed by GC-FID, GC-MS and 13C-NMR and thirty-six different compounds were identified. Pumiloxide, an unusual labdane diterpene, was found to be one of the major components in both oils (15.3 % and 12.3 %, re...

journal_title：Planta medica

authors： Vila R,Mundina M,Tomi F,Furlán R,Zacchino S,Casanova J,Cañigueral S

更新日期：2002-02-01 00:00:00

abstract：:Bioassay-guided fractionation of the roots of Ardisia cornudentata Mez (Myrsinaceae) led to the isolation of three new compounds, 3-methoxy-2-methyl-5-pentylphenol (1), 3-methoxy-2-methyl-5-(1'-ketopentyl)phenol (2), and cornudoside (3), together with twenty-six known compounds. Their structures were elucidated by ana...

journal_title：Planta medica

authors： Chang CP,Chang HS,Peng CF,Lee SJ,Chen IS

更新日期：2011-01-01 00:00:00

abstract：:A novel experimental model of free radical-induced emesis for screening anti-emetic compounds from natural sources was established. 2,2'-Azobis(2-amidinopropane) dihydrochloride (AAPH) dissolved in liposome induced emesis in young chickens, and the emesis was prevented by antioxidants including N-(2-mercaptopropionyl)...

journal_title：Planta medica

authors： Yang Y,Kinoshita K,Koyama K,Takahashi K,Tai T,Nunoura Y,Watanabe K

更新日期：1999-08-01 00:00:00

abstract：:Three new depsidones, parmosidones F - G (1 - 2), and 8'-O-methylsalazinic acid (3), and 3 new diphenylethers, parmetherines A - C (4 - 6), together with 2 known congeners were isolated from the whole thalli of Parmotrema dilatatum, a foliose chlorolichen. Their structures were unambiguously determined by extensive sp...

journal_title：Planta medica

authors： Devi AP,Duong TH,Ferron S,Beniddir MA,Dinh MH,Nguyen VK,Pham NK,Mac DH,Boustie J,Chavasiri W,Pogam PL

更新日期：2020-11-01 00:00:00

abstract：:A phytochemical study of the roots of Pongamia pinnata afforded 29 flavanones and flavanols, including 7 previously undescribed compounds. The structures of the isolated compounds were determined by 1D and 2D NMR and mass spectroscopy data. The absolute configurations of the compounds were assigned via analysis of the...

journal_title：Planta medica

authors： Wen R,Lv H,Jiang Y,Tu P

更新日期：2018-11-01 00:00:00

abstract：:In a medium throughput screen of 880 plant and fungal extracts for antiprotozoal activity, a dichloromethane extract of Salvia miltiorrhiza roots was active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum. With HPLC-based activity profiling in combination with on- and off-line spectroscopic metho...

journal_title：Planta medica

authors： Slusarczyk S,Zimmermann S,Kaiser M,Matkowski A,Hamburger M,Adams M

更新日期：2011-09-01 00:00:00

abstract：:Pure compounds were isolated from plant extracts with antimalarial activity. The extracts were obtained from the tubers of Cyperus rotundus L. (Cyperaceae), the rootbark of Zanthoxylum gilletii (De Wild) Waterm. (Rutaceae), and the rootbark of Margaritaria discoidea (Baill.) Webster (Euphorbiaceae). The most active co...

journal_title：Planta medica

authors： Weenen H,Nkunya MH,Bray DH,Mwasumbi LB,Kinabo LS,Kilimali VA,Wijnberg JB

更新日期：1990-08-01 00:00:00

abstract：:Rutaecarpine is an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa. Recently, rutaecarpine has been characterized to have an anti-inflammatory activity through cyclooxygenase-2 inhibition. In the present studies, the effects of rutaecarpine on liver cytochrome P450 s (P450s) and P450 s involved...

journal_title：Planta medica

authors： Lee SK,Kim NH,Lee J,Kim DH,Lee ES,Choi HG,Chang HW,Jahng Y,Jeong TC

更新日期：2004-08-01 00:00:00

abstract：:A new resveratrol dimer, (+)-vitisinol E (1) which demonstrated inhibitory activity on BACE-1 (beta-site APP-cleaving enzyme 1) in vitro, was isolated from the stembark extract of Vitis vinifera (Vitaceae) together with four known resveratrol oligomers, (+)-epsilon-viniferin (2), (+)-ampelopsin A (3), (+)-vitisin A (4...

journal_title：Planta medica

authors： Choi YH,Yoo MY,Choi CW,Cha MR,Yon GH,Kwon DY,Kim YS,Park WK,Ryu SY

更新日期：2009-04-01 00:00:00

abstract：:Five new compounds (1-5), including two limonoids, one triterpenoid, one steroid, and one sesquiterpenoid, along with nine known limonoids (6-14), were isolated from the bark of Melia azedarach. The structures of the new compounds were elucidated by 2D NMR spectroscopy and mass spectrometry. The isolated compounds as ...

journal_title：Planta medica

authors： Yuan CM,Zhang Y,Tang GH,Li Y,He HP,Li SF,Hou L,Li XY,Di YT,Li SL,Hua HM,Hao XJ

更新日期：2013-01-01 00:00:00

abstract：:The anti-inflammatory effects of boldine and reticuline isolated from Litsea cubeba were evaluated by using xylene-induced ear edema and carrageenan-induced paw edema in mice and rats. Our results demonstrated that intragastric administration with boldine and reticuline significantly mitigated ear weight in mice and d...

journal_title：Planta medica

authors： Yang X,Gao X,Cao Y,Guo Q,Li S,Zhu Z,Zhao Y,Tu P,Chai X

更新日期：2018-01-01 00:00:00

abstract：:Plectranthus barbatus Andr. is one of the most important species of the genus Plectranthus L' Herit. (Lamiaceae), with a wide variety of traditional medicinal uses in Hindu and Ayurvedic traditional medicine as well as in the folk medicine of Brazil, tropical Africa and China. The plant has therefore been an attractiv...

journal_title：Planta medica

authors： Alasbahi RH,Melzig MF

更新日期：2010-05-01 00:00:00

abstract：:Six pentacyclic triterpenic acid methyl esters have been isolated from the methylated ethyl acetate extract of the trunk wood of MUSANGA CECROPIOIDES, as well as a triterpene saponin of the same group. One of them, cecropic acid methyl ester, is new. The structures of these compounds have been established from interpr...

journal_title：Planta medica

authors： Lontsi D,Sondengam BL,Ayafor JF,Tsoupras MG,Tabacchi R

更新日期：1990-06-01 00:00:00

abstract：:Constitutively activated STAT3 plays a pivotal role in oncogenesis and metastasis in many human cancers, and STAT3 has been validated as a novel anticancer drug target. Thus, the identification of small molecules that modulate STAT3 activity could be of great therapeutic importance. The aim of this study was to isolat...

journal_title：Planta medica

authors： Liu J,Zhang Q,Chen K,Liu J,Kuang S,Chen W,Yu Q

更新日期：2012-09-01 00:00:00

abstract：:Ginkgetin, a biflavone isolated from Ginkgo biloba leaves, was previously reported as an inhibitor of group II phospholipase A2. In this study, ginkgetin was evaluated for in vivo antiarthritic and analgesic activities. Ginkgetin (10-20 mg/kg/day) strongly reduced arthritic inflammation in an animal model of rat adjuv...

journal_title：Planta medica

authors： Kim HK,Son KH,Chang HW,Kang SS,Kim HP

更新日期：1999-06-01 00:00:00

abstract：:Soybean saponin is one of several soybean glycosides. Recently, new soybean saponins which possess the DDMP (2,5-dihydroxy-6-methyl-2,3-dihydro-4H-pyran-4-one) moiety have been detected. Soyasaponin beta g of these new soybean saponins was shown to inhibit hydrogen peroxide damage to mouse fibroblast cells. Not only t...

journal_title：Planta medica

authors： Yoshikoshi M,Yoshiki Y,Okubo K,Seto J,Sasaki Y

更新日期：1996-06-01 00:00:00

abstract：:HPLC determinations of the aescin contents in calli and embryoids from leaf explants of AESCULUS HIPPOCASTANUM L. were carried out in order to determine whether it was possible to obtain aescin-forming proliferations IN VITRO. The results indicate that embryogenic calli and embryoids derived from them produce an amoun...

journal_title：Planta medica

authors： Profumo P,Caviglia AM,Gastaldo P,Dameri RM

更新日期：1991-02-01 00:00:00

abstract：:Flavonoids are metabolized in vivo to monocyclic phenolic acids. We investigated whether 18 phenolic acids of the benzoic, phenylacetic, phenylpropanoic or cinnamic series-known or potential metabolites of flavonoids-inhibit reactive oxygen species (ROS) released by human polymorphonuclear neutrophils (PMNs). Chemilum...

journal_title：Planta medica

authors： Limasset B,Ojasoo T,le Doucen C,Doré JC

更新日期：1999-02-01 00:00:00

abstract：:Thirty-five flavonoids of seven different types, namely isoflavonoids, chalcones, dihydroflavonols, flavanols, flavanones, flavones, and flavonols were investigated for their ability to inhibit ascorbate-induced microsomal lipid peroxidation and their cytotoxicity. For each activity a structure-activity relationship w...

journal_title：Planta medica

authors： Cos P,Calomme M,Sindambiwe JB,De Bruyne T,Cimanga K,Pieters L,Vlietinck AJ,Vanden Berghe D

更新日期：2001-08-01 00:00:00

abstract：:Five new triterpenoid saponins (1-5) and four known triterpenoid saponins, ginsenoside Re5 (6), majonoside R1 (7), 24(R)-majonoside R1 (8), and ginsenoside Rf (9), were isolated from the rhizomes of Panacis majoris. The structures of new compounds were elucidated as (20S,24S,25R*)-6-O-[β-D-glucopyranosyl-(1 → 2)-β-D-g...

journal_title：Planta medica

authors： Li M,Liu F,Jin YR,Wang XZ,Wu Q,Liu Y,Li XW

更新日期：2017-02-01 00:00:00

abstract：:The active ingredient dl-tetrahydropalmatine (THP) isolated from the traditional Chinese herb Corydalis racemosa has been found to have antihypertensive effects. However, severe cardiac and neurological toxic effects were reported from using this herb for the treatment of pain. In an isolated perfused rat heart model,...

journal_title：Planta medica

authors： Chan P,Chiu WT,Chen YJ,Wu PJ,Cheng JT

更新日期：1999-05-01 00:00:00

abstract：:The solid dispersion of a poorly water-soluble Silybum marianum extract (SME) was prepared by a one-step fluid-bed coating technique depositing onto non-pareil pellets. In vitro evaluation indicated that this technique was highly efficient and reproducible producing pellets with acceptable appearance, flowability, fri...

journal_title：Planta medica

authors： Sun N,Zhang X,Lu Y,Wu W

更新日期：2008-02-01 00:00:00

abstract：:Silybum marianum Gaertn. (Milk thistle) has been used since ancient times for the relief of liver diseases characterized by intense oxidative stress such as inflammatory liver disease and cirrhosis. As oxidative stress by hyperglycemia is involved in micro- and macrovascular complications of type 2 diabetes, our aim w...

journal_title：Planta medica

authors： Palomino OM,Gouveia NM,Ramos S,Martín MA,Goya L

更新日期：2017-01-01 00:00:00

abstract：:A new lignan glycoside, named eleutheroside E(2) (1), has been isolated from the roots of Eleutherococcus senticosus (known as "Siberian ginseng"), along with isomaltol 3-O-alpha-D-glucopyranoside (2), eleutherosides B, E and E(1), and thymidine. The structure of 1 was established by spectral interpretations as episyr...

journal_title：Planta medica

authors： Li XC,Barnes DL,Khan IA

更新日期：2001-11-01 00:00:00

abstract：:Alpinia galanga, or galangal, has been a popular condiment used in Thai and Asian cuisine for many years. However, relatively little is known of the potential beneficial or adverse health effects of this spice. This study was conducted to analyze the capacity of galangal extract to induce cytotoxicity and DNA damage i...

journal_title：Planta medica

authors： Muangnoi P,Lu M,Lee J,Thepouyporn A,Mirzayans R,Le XC,Weinfeld M,Changbumrung S

更新日期：2007-07-01 00:00:00

abstract：:Mulberroside A, a major stilbene constituent of MORUS ALBA L. (Moraceae), displays significant antitussive and antiasthmatic effects in animals. As part of our ongoing research on its biotransformation in rats, mulberroside A was orally administered to rats, and the metabolites in the gastrointestinal contents and fec...

journal_title：Planta medica

authors： Zhaxi M,Chen L,Li X,Komatsu K,Yao X,Qiu F

更新日期：2010-03-01 00:00:00

abstract：:A callus culture of Aleurites fordii Hemsley (Euphorbiaceae) producing five galloylglucoses and an ellagitannin, geraniin, was established. The production of pentagalloylglucose was remarkably enhanced under light irradiation compared with that in the dark. Cell growth and tannin production were also greatly affected ...

journal_title：Planta medica

authors： Taniguchi S,Uechi K,Kato R,Ito H,Hatano T,Yazaki K,Yoshida T

更新日期：2002-12-01 00:00:00

abstract：:The chemical composition of the essential oil of CYMBOPOGON TRAVANCORENSIS Bor. (Poaceae) was investigated by capillary GC and GC-MS. Thirty-five compounds were identified. The oil contains mono- and sesquiterpene hydrocarbons (39.60%), oxygenated terpenes (30.45%), and phenyl propanoids (22.04%). The main constituent...

journal_title：Planta medica

authors： Mallavarapu GR,Ramesh S,Kulkarni RN,Syamasundar KV

更新日期：1992-04-01 00:00:00

abstract：:Natural compounds have been the first historical source of antithrombotic compounds (heparin, vitamin K antagonists, streptokinase, urokinase); molecules extracted from plants or animals still provide some of the most original and promising approaches for the discovery of new drugs in this class. In this review, we wi...

journal_title：Planta medica

authors： Beretz A,Cazenave JP

更新日期：1991-10-01 00:00:00