Abstract:
:A novel experimental model of free radical-induced emesis for screening anti-emetic compounds from natural sources was established. 2,2'-Azobis(2-amidinopropane) dihydrochloride (AAPH) dissolved in liposome induced emesis in young chickens, and the emesis was prevented by antioxidants including N-(2-mercaptopropionyl)-glycine (MPG), alpha-tocopherol, and L-ascorbic acid. Tropiseton, a serotonin receptor antagonist, also prevented emesis induced by AAPH. Known anti-emetic drugs and anti-emetic principles from natural sources also showed significant retching inhibition in the experiment using this system.
journal_name
Planta Medjournal_title
Planta medicaauthors
Yang Y,Kinoshita K,Koyama K,Takahashi K,Tai T,Nunoura Y,Watanabe Kdoi
10.1055/s-2006-960829subject
Has Abstractpub_date
1999-08-01 00:00:00pages
574-6issue
6eissn
0032-0943issn
1439-0221journal_volume
65pub_type
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