Two major urinary metabolites of scutellarin in rats.

Abstract:

:Urinary metabolites of scutellarin, the main effective constituent of breviscapine, a cerebrovascular and cardiovascular drug consisting of total flavonoids of Erigeron breviscapus, were investigated in rats. Two major metabolites were isolated from the urine of rats following oral administration of scutellarin and identified as scutellarein 6,7-di- O-beta-D-glucuronide (M1) and scutellarein (M2), respectively, on the basis of chemical and spectroscopic evidence. M1 was reported as a metabolite of scutellarin for the first time.

journal_name

Planta Med

journal_title

Planta medica

authors

Qiu F,Xia H,Zhang T,Di X,Qu G,Yao X

doi

10.1055/s-2007-967128

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

363-5

issue

4

eissn

0032-0943

issn

1439-0221

journal_volume

73

pub_type

杂志文章
  • Activity on the central nervous system of Himanthalia elongata.

    abstract::We report the effects of a fraction (F1) obtained from Himanthalia elongata on spontaneous locomotor activity, hypermotility, motor coordination, rectal temperature, pentobarbitone-induced hypnosis, pentylenetetrazole-induced convulsions and analgesic activity in the writhing and hot-plate tests. This fraction caused ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-959655

    authors: Anca JM,Lamela M,Calleja JM

    更新日期:1993-06-01 00:00:00

  • Anthraquinones of Cassia marginata seeds.

    abstract::From the defatted seeds of Cassia marginata fam (Caesalpinaceae) two new anthraquinone glycosides have been isolated and characterised as physcion-8-O-alpha-L-xylopyranoside and emodin-8-O-alpha-L-arabinopyranoside. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-971241

    authors: Duggal JK,Misra K

    更新日期:1982-05-01 00:00:00

  • Geniposide, an iridoid glucoside derived from Gardenia jasminoides, protects against lipopolysaccharide-induced acute lung injury in mice.

    abstract::Geniposide, a main iridoid glucoside component of gardenia fruit, has been shown to possess anti-inflammatory activity. However, its potential use for acute lung injury (ALI) has not yet been studied. The aim of this study was to evaluate the anti-inflammatory properties of geniposide using a mouse ALI model. ALI was ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0031-1298212

    authors: Xiaofeng Y,Qinren C,Jingping H,Xiao C,Miaomiao W,Xiangru F,Xianxing X,Meixia H,Jing L,Jingyuan W,Xinxin C,Hongyu L,Yanhong D,Lanxiang J,Xuming D

    更新日期:2012-04-01 00:00:00

  • Decursinol angelate: a cytotoxic and protein kinase C activating agent from the root of Angelica gigas.

    abstract::A cytotoxic compound was purified from the root of Angelica gigas Nakai by normal phase HPLC. As a result of the structure analysis by mass, IR, 1H-NMR, and 13C-NMR spectrometry, the compound was identified as decursinol angelate, a structural isomer of decursin, and characterized originally from Sesei grandivittatum....

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2006-957701

    authors: Ahn KS,Sim WS,Lee IK,Seu YB,Kim IH

    更新日期:1997-08-01 00:00:00

  • Intestinal transport of 3,6'-disinapoylsucrose, a major active component of Polygala tenuifolia, using Caco-2 cell monolayer and in situ rat intestinal perfusion models.

    abstract::3,6'-Disinapoylsucrose is a major active component of the herb Polygala tenuifolia which has long been used for relieving tranquilization, uneasiness of the mind, and improving learning and memory. Our previous study found that 3,6'-disinapoylsucrose had a very low oral bioavailability. Its mechanisms of absorption in...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0033-1350794

    authors: Chen Y,Liu X,Pan R,Zhu X,Steinmetz A,Liao Y,Wang N,Peng B,Chang Q

    更新日期:2013-10-01 00:00:00

  • Antiproliferative effects on tumour cells and promotion of keratinocyte wound healing by different lichen compounds.

    abstract::Five compounds representative of major structural classes of lichen polyketides, VIZ. (+)-usnic (1), salazinic (2), vulpinic (3), gyrophoric (4), and evernic acids (5), were investigated for their ability to affect cell proliferation or wound healing, two functional targets of relevance for research on cancer or tissu...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0029-1185329

    authors: Burlando B,Ranzato E,Volante A,Appendino G,Pollastro F,Verotta L

    更新日期:2009-05-01 00:00:00

  • Effect of abietane diterpenes from Plectranthus grandidentatus on the growth of human cancer cell lines.

    abstract::Five known abietane diterpenes, fatty acid esters of 7alpha-acyloxy-6beta-hydroxyroyleanone (1), grandidone A (2), 7alpha-acetoxy-6beta-hydroxyroyleanone (3), 6beta,7alpha-dihydroxyroyleanone (4), and coleon U (5), isolated from Plectranthus grandidentatus Gürke, were evaluated for their in vitro antiproliferative act...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2002-34407

    authors: Marques CG,Pedro M,Simões MF,Nascimento MS,Pinto MM,Rodríguez B

    更新日期:2002-09-01 00:00:00

  • Tea triterpenoidal saponins from the roots of Camellia sinensis have inhibitory effects against alcohol dehydrogenase.

    abstract::Ten new polyhydroxyolean-12-ene pentacyclic triterpenoidal saponins, named rogchaponins 1-10, were isolated from the methanolic extract of the roots of Camellia sinensis by a series of chromatographic methods (silica gel flash column and C18 MPLC followed by C18 HPLC). Their structures were established by 1D and 2D-NM...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0031-1280024

    authors: Varughese T,Manir MM,Rahaman M,Kim JK,Lee BG,Moon SS

    更新日期:2011-12-01 00:00:00

  • Bioavailability, pharmacokinetics, and tissue distribution of the oxypregnane steroidal glycoside P57AS3 (P57) from Hoodia gordonii in mouse model.

    abstract::P57AS3 (P57), an oxypregnane steroidal glycoside, is known to be responsible for the appetite suppressing activity of HOODIA GORDONII, a dietary supplement used for weight loss. In this study, bioavailability, pharmacokinetics, and tissue distribution of P57 were determined in CD1 female mice after administration of a...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0030-1249818

    authors: Madgula VL,Ashfaq MK,Wang YH,Avula B,Khan IA,Walker LA,Khan SI

    更新日期:2010-10-01 00:00:00

  • Effect of astilbin on experimental diabetic nephropathy in vivo and in vitro.

    abstract::Astilbin, a flavonoid compound, was isolated from the rhizome of Smilax glabra Roxb. This study was conducted to investigate the efficacy of astilbin on experimental diabetic nephropathy (DN) in vivo and in vitro and its possible mechanisms. Astilbin was added in high glucose stimulated HK-2 cells, streptozotocin-indu...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0029-1185802

    authors: Li GS,Jiang WL,Yue XD,Qu GW,Tian JW,Wu J,Fu FH

    更新日期:2009-11-01 00:00:00

  • Antiviral Activity of a Arisaema Tortuosum Leaf Extract and Some of its Constituents against Herpes Simplex Virus Type 2.

    abstract::Infections caused by HSV-2 are a public health concern worldwide, and there is still a great demand for the discovery of novel anti-herpes virus agents effective against strains resistant to current antiviral agents. In this context, medicinal plants represent an alternative source of active compounds for developing e...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/a-1087-8303

    authors: Rittà M,Marengo A,Civra A,Lembo D,Cagliero C,Kant K,Lal UR,Rubiolo P,Ghosh M,Donalisio M

    更新日期:2020-03-01 00:00:00

  • Effects of estradiol benzoate, raloxifen and an ethanolic extract of Cimicifuga racemosa in nonclassical estrogen regulated organs of ovariectomized rats.

    abstract::The special extract of Cimicifuga racemosa (CR) BNO 1055 was shown to have bone protective effects without exerting estrogenic effects in the uterus or mammary gland. Whether the effects of CR BNO 1055 would be exerted in other organs that also express estrogen receptors (ERs) but in which the effects of estrogens and...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0029-1185561

    authors: Seidlova-Wuttke D,Jarry H,Wuttke W

    更新日期:2009-10-01 00:00:00

  • Purification and biochemical characterization of a novel allergenic protein from tatary buckwheat seeds.

    abstract::An allergenic protein from tatary buckwheat seeds, designated TBt, was purified by salting out, anion exchange chromatography and size exclusion chromatography (SEC). Analysis by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and SEC showed that the allergenic protein was composed of two subunits...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0028-1088319

    authors: Zhang X,Cui X,Li Y,Wang Z

    更新日期:2008-12-01 00:00:00

  • Formation of Digitalis lanata Clone Lines by Shoot Tip Culture.

    abstract::Propagation of DIGITALIS LANATA by shoot tip culture made possible (a) the rapid multiplication of elite plants with the formation of plant clones and (b) the long-term cultivation of these plants which under normal growth conditions would die at the end of the second vegetation period. Optimum conditions were establi...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-960883

    authors: Diettrich B,Mertinat H,Luckner M

    更新日期:1990-02-01 00:00:00

  • The Effects of a Fixed Combination of Berberis aristata and Silybum marianum on Dyslipidaemia - A Meta-analysis and Systematic Review.

    abstract::A fixed combination of Berberis aristata and Silybum marianum (Berberol) has been used by patients with dyslipidaemia. The aim of the present meta-analysis was to systematically evaluate the efficacy and safety of a fixed combination of B. aristata and S. marianum (Berberol) on serum lipid levels compared to placebo i...

    journal_title:Planta medica

    pub_type: 杂志文章,meta分析

    doi:10.1055/a-1063-1649

    authors: Tóth B,Németh D,Soós A,Hegyi P,Pham-Dobor G,Varga O,Varga V,Kiss T,Sarlós P,Erőss B,Csupor D

    更新日期:2020-01-01 00:00:00

  • Plants: a source for new antimycobacterial drugs.

    abstract::Tuberculosis, also called TB, is currently a major health hazard due to multidrug-resistant forms of bacilli. Global efforts are underway to eradicate TB using new drugs with new modes of action, higher activity, and fewer side effects in combination with vaccines. For this reason, unexplored new sources and previousl...

    journal_title:Planta medica

    pub_type: 杂志文章,评审

    doi:10.1055/s-0033-1350978

    authors: Santhosh RS,Suriyanarayanan B

    更新日期:2014-01-01 00:00:00

  • The inhibitory effects of jujuboside A on rat hippocampus in vivo and in vitro.

    abstract::Jujuboside A (JuA) is a glycoside extracted from the seed of Ziziphus jujuba Mill var. spinosa (Bunge) Hu ex H F Chou, a Chinese herbal medicine, which has long been known as a sedative-hypnotic drug. The present study used the method of intracerebroventricular (i.c.v.) JuA in vivo to detect the effect of JuA on paire...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2002-34398

    authors: Shou C,Feng Z,Wang J,Zheng X

    更新日期:2002-09-01 00:00:00

  • Anti-amoebic Activity of Leaf Extracts and Aporphine Alkaloids Obtained from Annona purpurea.

    abstract::Annona purpurea has been traditionally used by indigenous and socioeconomically disadvantaged people to treat infectious and parasitic diseases, including amoebiasis. The goal of this study was to assess the effect of a crude methanolic extract, an alkaloid extract, and aporphine alkaloids from leaves of A. purpurea o...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/a-1111-9566

    authors: Díaz-Godínez C,Ontiveros-Rodríguez JC,Ríos-Valencia DG,Herbert-Pucheta JE,Zepeda-Vallejo LG,Carrero JC

    更新日期:2020-04-01 00:00:00

  • Essential oil composition and antimicrobial activity of three Zingiberaceae from S.Tomé e Príncipe.

    abstract::The essential oil composition of three Zingiberaceae widely used as medicinal aromatic plants from S. Tomé and Príncipe: Aframomum danielli (Hook. f.) K. Schum., Curcuma longa L. and Zingiber officinale Rosc. was studied. Two samples of the essential oils from fruit of A. danielli and from rhizomes of the other two sp...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2001-16494

    authors: Martins AP,Salgueiro L,Gonçalves MJ,da Cunha AP,Vila R,Cañigueral S,Mazzoni V,Tomi F,Casanova J

    更新日期:2001-08-01 00:00:00

  • Quantitative analysis of strychnine and Brucine in Strychnos nux-vomica using 1H-NMR.

    abstract::A quantitative analysis using (1)H-NMR (Q-NMR) has been developed for the determination of strychnine and brucine in Strychnos nux-vomica seeds and stems. The advantages of the method are that no reference alkaloids are needed for calibration curves, the quantification could be directly realized on a crude extract, st...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2003-818014

    authors: Frédérich M,Choi YH,Verpoorte R

    更新日期:2003-12-01 00:00:00

  • Gingerols of Zingiber officinale enhance glucose uptake by increasing cell surface GLUT4 in cultured L6 myotubes.

    abstract::In this study we investigate the active constituents of the rhizome of Zingiber officinale, Roscoe (ginger) and determine their activity on glucose uptake in cultured L6 myotubes and the molecular mechanism underlying this action. Freeze-dried ginger powder was extracted with ethyl acetate (1 kg/3 L) to give the total...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0032-1315041

    authors: Li Y,Tran VH,Duke CC,Roufogalis BD

    更新日期:2012-09-01 00:00:00

  • A new alkaloid from Corydalis hendersonii.

    abstract::A new isoquinoline alkaloid (6), along with nine known ones (1-5, 7-10), was isolated from the plateau plant Corydalis hendersonii, which is used as a traditional Tibetan medicine. The structure of the new compound was elucidated as 9-methyldecumbenine C by spectroscopic evidence. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0029-1185331

    authors: Fu Y,Zhou Y,Liao X,Bai B,Peng S,Ding L

    更新日期:2009-04-01 00:00:00

  • Chemical and Biological Aspects of Marine Sponges from the Family Mycalidae.

    abstract::Sponges are a useful source of bioactive natural products. Members of the family Mycalidae, in particular, have provided a variety of chemical structures including alkaloids, polyketides, terpene endoperoxides, peptides, and lipids. This review highlights the compounds isolated from Mycalid sponges and their associate...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0042-103245

    authors: Habener LJ,Hooper JN,Carroll AR

    更新日期:2016-06-01 00:00:00

  • Guaianolides from Lactuca saligna.

    abstract::The phytochemical investigation of the aerial parts of LACTUCA SALIGNA L. revealed the presence of lactucin, lactucopicrin, and a new guaianolide named 11beta,13-dihydrolactucopicrin. The structural configuration was established through spectral data. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-960064

    authors: Khalil AT,El-Fattah HA,Mansour ES

    更新日期:1991-04-01 00:00:00

  • New ester alkaloids from lupins (genus lupinus).

    abstract::Esters of 13-hydroxylupanine and 4-hydroxylupanine with acetic, propionic, butyric, isobutyric, valeric, isovaleric, tiglic, benzoic, and TRANS-cinnamic acid have been synthesized and characterized by capillary gas-liquid chromatography and mass spectrometry (EI-MS, CI-MS). In LUPINUS POLYPHYLLUS, L. ALBUS, L. ANGUSTI...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-962415

    authors: Mühlbauer P,Witte L,Wink M

    更新日期:1988-06-01 00:00:00

  • A new diterpene from Tanaecium jaroba.

    abstract::One new diterpene, 2 alpha-hydroxy-12beta-hydroxy-isopimara-8(14), 15-diene, and six known compounds as triterpenes, sterols and fatty acid, were isolated from the stem bark of Tanaecium jaroba (Bignoniaceae), a Bolivian plant used in traditional medicine. Their structures were established mainly by 1D and 2D NMR (COS...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2002-32553

    authors: Mitaine-Offer AC,Sauvain M,Deharo E,Muñoz V,Zèches-Hanrot M

    更新日期:2002-06-01 00:00:00

  • Effects of auxins on growth and saponin production in callus cultures of Panax ginseng.

    abstract::A callus was induced from the petiole of Panax ginseng C. A. Meyer by treatment with 2,4-D. The callus has been maintained on the synthetic media containing 2,4-D as growth factor. Habituated ginseng callus which required no auxin for its growth was induced from a 2,4-D callus by successive treatments with a low conce...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-969981

    authors: Furuya T,Yoshikawa T,Ishii T,Kajii K

    更新日期:1983-03-01 00:00:00

  • Salidroside, the main active compound of Rhodiola plants, inhibits high glucose-induced mesangial cell proliferation.

    abstract::Because Rhodiola plants are known to have a protective effect on diabetic nephropathy, this study aimed to investigate the inhibitory effect of salidroside, the main active component of Rhodiola plants, on high glucose-induced mesangial cell proliferation and its possible mechanism. Salidroside (1 approximately 100 mi...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0029-1185717

    authors: Yin D,Yao W,Chen S,Hu R,Gao X

    更新日期:2009-09-01 00:00:00

  • Cytotoxicity and lipid peroxidation-inhibiting activity of flavonoids.

    abstract::Thirty-five flavonoids of seven different types, namely isoflavonoids, chalcones, dihydroflavonols, flavanols, flavanones, flavones, and flavonols were investigated for their ability to inhibit ascorbate-induced microsomal lipid peroxidation and their cytotoxicity. For each activity a structure-activity relationship w...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2001-16472

    authors: Cos P,Calomme M,Sindambiwe JB,De Bruyne T,Cimanga K,Pieters L,Vlietinck AJ,Vanden Berghe D

    更新日期:2001-08-01 00:00:00

  • New nervogenic acid derivatives from Liparis nervosa.

    abstract::Ten new nervogenic acid derivatives (1-4, 6-11) and one known compound (5) have been isolated from Liparis nervosa. Their structures were determined using extensive spectroscopic analysis, including 1D and 2D NMR experiments. Compounds 3, 4, 9, 10, and 11 were evaluated for their cytotoxicity against A549, H460, Hela,...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0032-1328109

    authors: Huang S,Zhou XL,Wang CJ,Wang HY,Wang YS,Shan LH,Weng J

    更新日期:2013-03-01 00:00:00