Abstract:
:Urinary metabolites of scutellarin, the main effective constituent of breviscapine, a cerebrovascular and cardiovascular drug consisting of total flavonoids of Erigeron breviscapus, were investigated in rats. Two major metabolites were isolated from the urine of rats following oral administration of scutellarin and identified as scutellarein 6,7-di- O-beta-D-glucuronide (M1) and scutellarein (M2), respectively, on the basis of chemical and spectroscopic evidence. M1 was reported as a metabolite of scutellarin for the first time.
journal_name
Planta Medjournal_title
Planta medicaauthors
Qiu F,Xia H,Zhang T,Di X,Qu G,Yao Xdoi
10.1055/s-2007-967128subject
Has Abstractpub_date
2007-04-01 00:00:00pages
363-5issue
4eissn
0032-0943issn
1439-0221journal_volume
73pub_type
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