Abstract:
:Five known abietane diterpenes, fatty acid esters of 7alpha-acyloxy-6beta-hydroxyroyleanone (1), grandidone A (2), 7alpha-acetoxy-6beta-hydroxyroyleanone (3), 6beta,7alpha-dihydroxyroyleanone (4), and coleon U (5), isolated from Plectranthus grandidentatus Gürke, were evaluated for their in vitro antiproliferative activity against five human cancer cell lines MCF-7, NCI-H460, SF-268, TK-10, and UACC-62. Coleon U (5) exhibited the strongest effect among all the assayed compounds. The abietane 3 revealed also a strong inhibitory effect while diterpenes 2 and 4 inhibited only slightly the growth of all cancer cell lines.
journal_name
Planta Medjournal_title
Planta medicaauthors
Marques CG,Pedro M,Simões MF,Nascimento MS,Pinto MM,Rodríguez Bdoi
10.1055/s-2002-34407subject
Has Abstractpub_date
2002-09-01 00:00:00pages
839-40issue
9eissn
0032-0943issn
1439-0221journal_volume
68pub_type
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