Abstract:
:Three flavonoids: norwogonin, dihydronorwogonin and baicalein, were isolated from the roots of Scutellaria baicalensis, as potential inhibitors of VHR dual-specificity protein tyrosine phosphatase (DS-PTPase). Norwogonin (IC 50 = 1.1 microM), dihydronorwogonin (IC 50 = 2.9 microM) and baicalein (IC 50 = 2.4 microM) showed potent inhibitory activity toward VHR, but had no inhibitory activity against T-cell protein tyrosine phosphatase or serine/threonine protein phosphatase 1. From comparisons to the inhibitory activities of other similar flavonoids, it could be suggested that the presence of a hydroxy group in the B ring of flavonoids interferes with the inhibitory activity toward VHR DS-PTPase.
journal_name
Planta Medjournal_title
Planta medicaauthors
Lee MS,Oh WK,Kim BY,Ahn SC,Kang DO,Sohn CB,Osada H,Ahn JSdoi
10.1055/s-2002-36351subject
Has Abstractpub_date
2002-12-01 00:00:00pages
1063-5issue
12eissn
0032-0943issn
1439-0221journal_volume
68pub_type
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