Abstract:
:A phytochemical investigation of the whole plants of Cassia occidentalis led to the isolation of two new cycloartane triterpenoids, cycloccidentalic acids A and B (1 and 2), and five new related saponins, cycloccidentalisides I-V (3-7), together with sixteen known compounds. The structures of the isolated compounds were elucidated through detailed spectroscopic analyses, including 1D and 2D NMR techniques, and chemical methods. Compounds 2 and 5 showed modest anti-HIV-1 activities with EC₅₀ values of 2.23 µM and 4.36 µM, respectively, in comparison to the positive control.
journal_name
Planta Medjournal_title
Planta medicaauthors
Li SF,Di YT,Luo RH,Zheng YT,Wang YH,Fang X,Zhang Y,Li L,He HP,Li SL,Hao XJdoi
10.1055/s-0031-1298376subject
Has Abstractpub_date
2012-05-01 00:00:00pages
821-7issue
8eissn
0032-0943issn
1439-0221journal_volume
78pub_type
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