Abstract:
:Immune complex binding to macrophages was enhanced by treatment with an E. kansui extract. Systematic fractionation of the extract led to the characterization of 3-O-(2'E,4'Z-decadienoyl)- and 3-O-(2,3-dimethylbutyryl)-13- O-n-dodecanoyl-13-hydroxyingenol as the active principles. Immune complex binding to macrophages by the action of these compounds increased in a dose-dependent manner. When each ingenol (10 nM) was added to the separated culture medium, the immune complex binding ability of macrophages increased up to 2-fold, respectively. Scatchard analysis showed the enhanced expression of the Fc-receptor for gamma-globulin by the action of each ingenol to macrophages. This Fc-receptor upregulation was dependent on RNA synthesis, suggesting a possible de novo synthesis.
journal_name
Planta Medjournal_title
Planta medicaauthors
Matsumoto T,Cyong JC,Yamada Hdoi
10.1055/s-2006-961447subject
Has Abstractpub_date
1992-06-01 00:00:00pages
255-8issue
3eissn
0032-0943issn
1439-0221journal_volume
58pub_type
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