Abstract:
:Four new phenanthroindolizidine alkaloids, tylophoridicines C-F, together with three known ones, R-(+)-deoxytylophorinidine, tylophorinine and tylophorinidine, were isolated from the roots of Tylophora atrofolliculata. The structures were determined on the basis of spectral evidence. These alkaloids exhibited cytotoxic activity in vitro on HCT-8 cell (with IC50 values in the range 0.083 to 18.99 microM) and KB cell (in the range 3.56 to 18.22 microM) lines.
journal_name
Planta Medjournal_title
Planta medicaauthors
Huang X,Gao S,Fan L,Yu S,Liang Xdoi
10.1055/s-2004-818973subject
Has Abstractpub_date
2004-05-01 00:00:00pages
441-5issue
5eissn
0032-0943issn
1439-0221journal_volume
70pub_type
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