Two new secoiridoid glycosides from Gentiana algida.

abstract：:In our investigation of in vitro antimalarial screening of medicinal herbal extracts, the n-BuOH extract from the root of Wikstroemia indica showed a potent inhibitory effect. Fractionation of the active extract led to the isolation of two biflavonoids, sikokianin B ( 1) and sikokianin C ( 2) with IC (50) values 0.54 ...

journal_title：Planta medica

authors： Nunome S,Ishiyama A,Kobayashi M,Otoguro K,Kiyohara H,Yamada H,Omura S

更新日期：2004-01-01 00:00:00

abstract：:At the early drug discovery stage, the high-throughput parallel artificial membrane permeability assay is one of the most frequently used in vitro models to predict transcellular passive absorption. While thousands of new chemical entities have been screened with the parallel artificial membrane permeability assay, in...

journal_title：Planta medica

authors： Petit C,Bujard A,Skalicka-Woźniak K,Cretton S,Houriet J,Christen P,Carrupt PA,Wolfender JL

更新日期：2016-03-01 00:00:00

abstract：:One new drimane-type sesquiterpenoid, 3 β-angeloyloxy-7-epifutronolide (1), and one new natural product, polygonumate (2), along with six known drimane-type sesquiterpenes [dendocarbin L (3), (+) winterin (4), (+) fuegin (5), changweikangic acid A (6), futronolide (7), and 7-ketoisodrimenin (8)] were isolated from the...

journal_title：Planta medica

authors： Sultana R,Hossain R,Adhikari A,Ali Z,Yousuf S,Choudhary MI,Ali MY,Zaman MS

更新日期：2011-11-01 00:00:00

abstract：:Ocimum tenuiflorum has been widely used in traditional medicine and has high medicinal value. High volume trade of this potential medicinal plant species led to unscrupulous adulteration of both crude drugs as well as formulations. Morphology-based authentication is difficult in cases of incomplete or damaged samples ...

journal_title：Planta medica

authors： Kumar A,Rodrigues V,Mishra P,Baskaran K,Shukla AK,Shasany AK,Sundaresan V

更新日期：2018-01-01 00:00:00

abstract：:Three new lycopodium alkaloids, 11alpha-hydroxyphlegmariurine B (2), 7alpha-hydroxyphlegmariurine B (3) and 7alpha,11alpha-dihydroxyphlegmariurine B (4) along with a known compound, phlegmariurine B (1), were isolated from the herb Huperzia serrata. The structures of the above compounds were elucidated based on spectr...

journal_title：Planta medica

authors： Tan CH,Wang BD,Jiang SH,Zhu DY

更新日期：2002-02-01 00:00:00

abstract：:In the present study, we demonstrate that saucernetin-8 ( 1) and saucernetin-7 ( 2), isolated from the underground parts of Saururus chinensis (Saururaceae), exerted potent inhibitory effects on LPS-induced nitric oxide (NO) and prostaglandin E (2) (PGE (2)) production in RAW 264.7 cells. Both compounds 1 and 2, known...

journal_title：Planta medica

authors： Park HJ,Kim RG,Seo BR,Ha J,Ahn BT,Bok SH,Lee YS,Kim HJ,Lee KT

更新日期：2003-10-01 00:00:00

abstract：:Pure compounds were isolated from plant extracts with antimalarial activity. The extracts were obtained from the tubers of Cyperus rotundus L. (Cyperaceae), the rootbark of Zanthoxylum gilletii (De Wild) Waterm. (Rutaceae), and the rootbark of Margaritaria discoidea (Baill.) Webster (Euphorbiaceae). The most active co...

journal_title：Planta medica

authors： Weenen H,Nkunya MH,Bray DH,Mwasumbi LB,Kinabo LS,Kilimali VA,Wijnberg JB

更新日期：1990-08-01 00:00:00

abstract：:Two triterpenoidal saponins having phytolaccagenin as the aglycone were isolated from the roots of Phytolacca esculenta (Phytolaccaceae). The structures of two new saponins, esculentoside I and esculentoside N, were established to be 3-O-[beta-D-glucopyranosyl-(1----4)-beta-D- glucopyranosyl]-28-O-beta-D-glucopyranosy...

journal_title：Planta medica

authors： Yi YH

更新日期：1992-02-01 00:00:00

abstract：:Overexpression of the protein transporter P-glycoprotein (Pgp, MDR1) at the cell surface is a major cause of multidrug resistance (MDR) and poor response to treatment in cancer chemotherapy and therapy for leishmaniasis. The present study shows that conferone, a sesquiterpene coumarin ether isolated for the first time...

journal_title：Planta medica

authors： Barthomeuf C,Demeule M,Grassi J,Saidkhodjaev A,Beliveau R

更新日期：2006-06-01 00:00:00

abstract：:Micellar electrokinetic capillary chromatography (MECC), using a phosphate buffer pH 7.0 and sodium dodecyl sulfate as the surfactant, was found suitable for the separation of structurally similar flavan-3-ols and related dimeric proanthocyanidins. A total of 20 substances has been tested, 17 of which were successfull...

journal_title：Planta medica

authors： Kreimeyer J,Petereit F,Nahrstedt A

更新日期：1998-02-01 00:00:00

abstract：:The specific physiological responses induced by inhaling R-(-)- as well as S-(+)-linalool in 24 human subjects undergoing experimental stress were investigated in this study. Various physiological parameters of the autonomous nervous system (heart rate, blood pressure, electrodermal activity) as well as the endocrine ...

journal_title：Planta medica

authors： Höferl M,Krist S,Buchbauer G

更新日期：2006-10-01 00:00:00

abstract：:Solasodine--a steroid present in the mucilaginous exotesta of the seed in Solanum viarum Dunal (syn. S. khasianum var. chatterjeeanum) is a major source of steroidal raw material. Evidence for the site of solasodine synthesis was sought through reciprocal grafts involving steroid-bearing S. viarum (both diploid and au...

journal_title：Planta medica

authors： Srinivas M,Krishnan R

更新日期：1996-08-01 00:00:00

abstract：:Several procyanidin dimers and an epicatechin trimer purified from Douglas fir bark tannins were compared with their monomer components (+)-catechin and (-)-epicatechin for their abilities to inhibit the biochemical effects of the potent tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) in mouse epidermis in v...

journal_title：Planta medica

authors： Gali HU,Perchellet EM,Gao XM,Karchesy JJ,Perchellet JP

更新日期：1994-06-01 00:00:00

abstract：:This Paper describes an improved HPLC method for the determination of pentacyclic oxindole alkaloids in Uncaria tomentosa (Cat's Claw). Six of the isomeric compounds could be baseline separated at room temperature within less than 30 min by using 3 microm C-18 column material and a mobile phase consisting of 10 mM pho...

journal_title：Planta medica

authors： Ganzera M,Muhammad I,Khan RA,Khan IA

更新日期：2001-07-01 00:00:00

abstract：:Chemical investigation of the EtOH extract of Morus alba L. (Moraceae), as guided by free radical scavenging activity, furnished 5,7-dihydroxycoumarin 7-methyl ether (1), two prenylflavones, cudraflavone B (2) and cudraflavone C (3), and oxyresveratrol (4). Compounds 1 and 4 showed superoxide scavenging effects with t...

journal_title：Planta medica

authors： Oh H,Ko EK,Jun JY,Oh MH,Park SU,Kang KH,Lee HS,Kim YC

更新日期：2002-10-01 00:00:00

abstract：:The crude extract (IPA) of the plant Ipomoea pes-caprae (L.) R. Br. showed an inhibitory effect on prostaglandin synthesis in vitro. Bioassay-guided separation of the extract led to the isolation of four active compounds: 2-hydroxy-4,4,7-trimethyl-1(4H)-naphthalenone (1), (-)-mellein (2), eugenol (3), and 4-vinyl-guai...

journal_title：Planta medica

authors： Pongprayoon U,Baeckström P,Jacobsson U,Lindström M,Bohlin L

更新日期：1991-12-01 00:00:00

abstract：:The oligomeric stilbenes (+)-alpha-viniferin (1), miyabenol C (2), and kobophenol A (3) have been isolated from Caragana sinica (Buchoz) Rehd (Leguminosae). (+)-alpha-Viniferin (1) and miyabenol C (2) exhibited protein kinase C inhibitory activity at low micromolar concentrations. (+)-alpha-Viniferin inhibited keratin...

journal_title：Planta medica

authors： Kulanthaivel P,Janzen WP,Ballas LM,Jiang JB,Hu CQ,Darges JW,Seldin JC,Cofield DJ,Adams LM

更新日期：1995-02-01 00:00:00

abstract：:A novel bibenzyl, a new bibenzyl, two new phenanthrenes, and a new lignin glycoside, namely longicornuol A (1), 4-[2-(3-hdroxyphenol)-1-methoxyethyl]-2,6-dimethoxyphenol (2), 5-hydroxy-7-methoxy-9,10-dihydrophenanthrene-1,4-dione (3), 7-methoxy-9,10-dihydrophenanthrene-2,4,5-triol (4) and erythro-1-(4-O-beta-D-glucopy...

journal_title：Planta medica

authors： Hu JM,Chen JJ,Yu H,Zhao YX,Zhou J

更新日期：2008-04-01 00:00:00

abstract：:Soybean saponin is one of several soybean glycosides. Recently, new soybean saponins which possess the DDMP (2,5-dihydroxy-6-methyl-2,3-dihydro-4H-pyran-4-one) moiety have been detected. Soyasaponin beta g of these new soybean saponins was shown to inhibit hydrogen peroxide damage to mouse fibroblast cells. Not only t...

journal_title：Planta medica

authors： Yoshikoshi M,Yoshiki Y,Okubo K,Seto J,Sasaki Y

更新日期：1996-06-01 00:00:00

abstract：:Calozeyloxanthone ( 1) was re-isolated from the root bark of Calophyllum moonii, an endemic species of Sri Lanka, and found to be active against vancomycin-resistant Enterococci (VRE) and vancomycin-sensitive Enterococci (VSE) with MIC values of 6.25 microg/ml and 12.5 microg/ml, respectively. Further, a marked synerg...

journal_title：Planta medica

authors： Sakagami Y,Kajimura K,Wijesinghe WM,Dharmaratne HR

更新日期：2002-06-01 00:00:00

abstract：:The acylphloroglucinol derivative hyperforin is a major constituent of St. John's wort extracts ( Hypericum perforatum L.), which has been demonstrated to contribute to the antidepressant action of this herbal drug. In previous investigations we observed that hyperforin causes a rapid stimulation of intracellular calc...

journal_title：Planta medica

authors： Schrattenholz A,Schroer K,Chatterjee SS,Koch E

更新日期：2004-04-01 00:00:00

abstract：:Danggui buxue tang, an ancient formula composed of astragali radix and Angelicae sinensis radix, has been used for treating menopausal irregularity in women for more than 800 years in China. In danggui buxue tang, the complete functions of astragali radix require the assistance of Angelicae sinensis radix, and both he...

journal_title：Planta medica

authors： Zheng KY,Zhang ZX,Du CY,Zhang WL,Bi CW,Choi RC,Dong TT,Tsim KW

更新日期：2014-02-01 00:00:00

abstract：:In order to evaluate the potency of novel antiviral drugs, 11 natural sulfated polysaccharides (SPs) from 10 green algae ( Enteromorpha compressa, Monostroma nitidum, Caulerpa brachypus, C. okamurai, C. scapelliformis, Chaetomorpha crassa, C. spiralis, Codium adhaerens, C. fragille, and C. latum) and 4 synthetic sulfa...

journal_title：Planta medica

authors： Lee JB,Hayashi K,Maeda M,Hayashi T

更新日期：2004-09-01 00:00:00

abstract：:Some enzymes of the terminal steps of phenylalanine and tyrosine biosyntheses were investigated in various alkaloid-forming ergot strains. All strains studied utilize both arogenate and phenylpyruvate as an intermediate in L-phenylalanine synthesis. L-Tyrosine is preferentially or exclusively synthesized via the aroge...

journal_title：Planta medica

authors： Schmauder HP,Gröger D

更新日期：1986-10-01 00:00:00

abstract：:Products derived from Noni fruit (Morinda citrifolia) have been commercialised in the USA since the 1990s and are increasingly distributed all over the world. A large number of beneficial effects have been claimed for Noni. Fruit juice of Noni has been approved as a Novel Food by the European Commission in 2003. This ...

journal_title：Planta medica

authors： Potterat O,Hamburger M

更新日期：2007-03-01 00:00:00

abstract：:A new tetrahydrofuranoketone lignan (1) and two new tetrahydrofuranoketone lignan glycosides (2, 3) were isolated from the ethanol extract of the aerial part of Mananthes patentiflora. The structure elucidations of these compounds were mainly established on the basis of 1D, 2D NMR and HR-mass spectroscopic analysis. A...

journal_title：Planta medica

authors： Tian J,Yang X,Di Y,Ma Y,Li L,Li L,He H,Hao X

更新日期：2009-04-01 00:00:00

abstract：:Cell Suspension cultures of THAMNOSMA MONTANA were grown in Gamborg B5 medium which was best suited for acridone alkaloid formation. From the lyophilized cell material nine acridones and three acridone-monoglucosides have been isolated which were found for the first time in the genus THAMNOSMA. Moreover, N-methylacrid...

journal_title：Planta medica

authors： Baumert A,Maier W,Matern U,Schmidt J,Schumann B,Gröger D

更新日期：1994-04-01 00:00:00

abstract：:The phenylpropanoid dibenzylbutyrolactone lignan arctigenin, a key component found in Arctium lappa, or burdock, has been reported with a variety of therapeutic effects including anticancer, anti-inflammation, and antivirus effects. Using LC/MS/MS, three novel metabolites of arctigenin, namely, arctigenic acid, arctig...

journal_title：Planta medica

authors： Gao Q,Zhang Y,Wo S,Zuo Z

更新日期：2013-04-01 00:00:00

abstract：:Khat (Catha edulis Forsk.) is a perennial shrub whose young leaves are chewed for their psychostimulating and anorectic properties. The main active principles of khat are believed to be the phenylpropylamino alkaloids, primarily (-)-cathinone [(S)-α-aminopropiophenone], (+)-cathine [(1S)(2S)-norpseudoephedrine], and (...

journal_title：Planta medica

authors： Krizevski R,Bar E,Dudai N,Levy A,Lewinsohn E,Sitrit Y,Ben-Shabat S

更新日期：2012-05-01 00:00:00

abstract：:3,6'-Disinapoylsucrose is a major active component of the herb Polygala tenuifolia which has long been used for relieving tranquilization, uneasiness of the mind, and improving learning and memory. Our previous study found that 3,6'-disinapoylsucrose had a very low oral bioavailability. Its mechanisms of absorption in...

journal_title：Planta medica

authors： Chen Y,Liu X,Pan R,Zhu X,Steinmetz A,Liao Y,Wang N,Peng B,Chang Q

更新日期：2013-10-01 00:00:00