Antibacterial activity of calozeyloxanthone isolated from Calophyllum species against vancomycin-resistant Enterococci (VRE) and synergism with antibiotics.

Abstract:

:Calozeyloxanthone ( 1) was re-isolated from the root bark of Calophyllum moonii, an endemic species of Sri Lanka, and found to be active against vancomycin-resistant Enterococci (VRE) and vancomycin-sensitive Enterococci (VSE) with MIC values of 6.25 microg/ml and 12.5 microg/ml, respectively. Further, a marked synergism between 1 and vancomycin hydrochloride (VCM) against VRE was also observed. These findings suggest that 1 in combination with VCM against VRE may be useful in controlling VRE infections.

journal_name

Planta Med

journal_title

Planta medica

authors

Sakagami Y,Kajimura K,Wijesinghe WM,Dharmaratne HR

doi

10.1055/s-2002-32558

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

541-3

issue

6

eissn

0032-0943

issn

1439-0221

journal_volume

68

pub_type

信件
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  • Structures of Crassicaulisine and Crassicaulidine, two New Diterpenoid Alkaloids.

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