Abstract:
:In our investigation of in vitro antimalarial screening of medicinal herbal extracts, the n-BuOH extract from the root of Wikstroemia indica showed a potent inhibitory effect. Fractionation of the active extract led to the isolation of two biflavonoids, sikokianin B ( 1) and sikokianin C ( 2) with IC (50) values 0.54 microg/mL and 0.56 microg/mL, respectively, against the chloroquine-resistant strain of Plasmodium falciparum. This is the first report of the biological activity of 1 and 2. As the structure of l has remained unsettled, we confirmed the conformation by (1)H- and (13)C-NMR.
journal_name
Planta Medjournal_title
Planta medicaauthors
Nunome S,Ishiyama A,Kobayashi M,Otoguro K,Kiyohara H,Yamada H,Omura Sdoi
10.1055/s-2004-815462subject
Has Abstractpub_date
2004-01-01 00:00:00pages
76-8issue
1eissn
0032-0943issn
1439-0221journal_volume
70pub_type
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