In vitro antimalarial activity of biflavonoids from Wikstroemia indica.

Abstract:

:In our investigation of in vitro antimalarial screening of medicinal herbal extracts, the n-BuOH extract from the root of Wikstroemia indica showed a potent inhibitory effect. Fractionation of the active extract led to the isolation of two biflavonoids, sikokianin B ( 1) and sikokianin C ( 2) with IC (50) values 0.54 microg/mL and 0.56 microg/mL, respectively, against the chloroquine-resistant strain of Plasmodium falciparum. This is the first report of the biological activity of 1 and 2. As the structure of l has remained unsettled, we confirmed the conformation by (1)H- and (13)C-NMR.

journal_name

Planta Med

journal_title

Planta medica

authors

Nunome S,Ishiyama A,Kobayashi M,Otoguro K,Kiyohara H,Yamada H,Omura S

doi

10.1055/s-2004-815462

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

76-8

issue

1

eissn

0032-0943

issn

1439-0221

journal_volume

70

pub_type

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