Abstract:
:In the present study, we demonstrate that saucernetin-8 ( 1) and saucernetin-7 ( 2), isolated from the underground parts of Saururus chinensis (Saururaceae), exerted potent inhibitory effects on LPS-induced nitric oxide (NO) and prostaglandin E (2) (PGE (2)) production in RAW 264.7 cells. Both compounds 1 and 2, known as dineolignans, also suppressed the expression of iNOS and COX-2 protein in a dose-dependent manner. Thus, this study suggests that compounds 1 and 2-mediated inhibition of iNOS and COX-2 expression may be one of the mechanisms responsible for the anti-inflammatory effects of the underground parts of Saururus chinensis.
journal_name
Planta Medjournal_title
Planta medicaauthors
Park HJ,Kim RG,Seo BR,Ha J,Ahn BT,Bok SH,Lee YS,Kim HJ,Lee KTdoi
10.1055/s-2003-45106subject
Has Abstractpub_date
2003-10-01 00:00:00pages
947-50issue
10eissn
0032-0943issn
1439-0221journal_volume
69pub_type
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