Naturally occurring protein kinase C inhibitors; II. Isolation of oligomeric stilbenes from Caragana sinica.

abstract：:Three new sauchinone analogues, sauchinones B-D (1-3), together with sauchinone (4), were isolated from the aerial part of Saururus chinensis. Structures of the new compounds were determined by extensive spectroscopic data as well as X-ray analysis. Compounds 3 and 4 inhibited nitric oxide production in lipopolysaccha...

journal_title：Planta medica

authors： Gao X,He J,Wu XD,Peng LY,Dong LB,Deng X,Li Y,Cheng X,Zhao QS

更新日期：2013-12-01 00:00:00

abstract：:The chloroform extract of the stems of Encelia ventorum yielded a new benzopyranbenzofuran dimer. The structure was assigned from (1)H-NMR and MS data as 4[2-(5-acetyl-6-hydroxybenzofuranyl)]-2-[6(7-methoxy-2, 2-dimethylbenzo-1 -pyranyl)]-pentan-2-ol. ...

journal_title：Planta medica

authors： Proksch P,Aregullin M,Rodriguez E

更新日期：1983-04-01 00:00:00

abstract：:The medicinal properties of curcumin obtained from Curcuma longa L. cannot be utilised because of poor bioavailability due to its rapid metabolism in the liver and intestinal wall. In this study, the effect of combining piperine, a known inhibitor of hepatic and intestinal glucuronidation, was evaluated on the bioavai...

journal_title：Planta medica

authors： Shoba G,Joy D,Joseph T,Majeed M,Rajendran R,Srinivas PS

更新日期：1998-05-01 00:00:00

abstract：:Aloe barbadensis polysaccharide was partially digested with cellulase and further purified by dialysis, stepwise ethanol precipitation, and size exclusion chromatography. Crude modified Aloe polysaccharide (MAP) activated macrophage cells and stimulated fibroblast growth. Under the same conditions, native Aloe barbade...

journal_title：Planta medica

authors： Qiu Z,Jones K,Wylie M,Jia Q,Orndorff S

更新日期：2000-03-01 00:00:00

abstract：:The flower buds of Lonicera japonica are widely used in Chinese medicine for their anti-inflammatory properties. The reason why L. japonica has potent and significant effects is that it contains various active components, especially chlorogenic acid (CGA). In the present study, we isolated a hydroxycinnamoyl-CoA quina...

journal_title：Planta medica

authors： Peng X,Li W,Wang W,Bai G

更新日期：2010-11-01 00:00:00

abstract：:Four new benzofurans trans-5-(3-hydroxypropyl)-7-methoxy-2-[2,3-dihydro-3-hydroxymethyl-7-methoxy-2-(3-methoxy-4-hydroxyphenyl)-benzofuran-5-yl]benzofuran (1), (E)-5-(2-formylvinyl)-7-methoxy-2-(3,4-methylenedioxyphenyl)benzofuran (2), 5-(3-butanoyloxypropyl)-7-methoxy-2-(3,4-methylenedioxyphenyl)benzofuran (3), and 5...

journal_title：Planta medica

authors： Li QL,Li BG,Qi HY,Gao XP,Zhang GL

更新日期：2005-09-01 00:00:00

abstract：:The natural compound tyropeptin A, a new peptidyl aldehyde proteasome inhibitor, was tested for its trypanocidal activity in vitro using culture-adapted bloodstream forms of Trypanosoma brucei. The concentrations of tyropeptin A required to reduce the growth rate by 50 % and to kill all cells were 10 and 100 times low...

journal_title：Planta medica

authors： Steverding D,Pemberton AJ,Royle H,Spackman RW,Rivett AJ

更新日期：2006-06-01 00:00:00

abstract：:We report the effects of aqueous extracts of the microalgae Dunaliella tertiolecta Butcher (Chlorophyceae) and Phaeodactylum tricornutum Bohlin (Bacillariophyceae) on oxotremorin-induced cholinergic symptoms, amphetamine-induced hypermotility, pentylenetetrazole-induced convulsions, and Rota-rod test performance. Both...

journal_title：Planta medica

authors： Laguna MR,Villar RM,Cadavid I,Calleja JM

更新日期：1990-04-01 00:00:00

abstract：:We describe in this paper that the alkaloid 4-methylaaptamine, isolated from the marine sponge Aaptos aaptos, inhibited HSV-1 infection. We initially observed that 4-methylaaptamine inhibited HSV-1 replication in Vero cells in a dose-dependent manner with an EC50 value of 2.4 microM. Moreover, the concentration requir...

journal_title：Planta medica

authors： Souza TM,Abrantes JL,de A Epifanio R,Leite Fontes CF,Frugulhetti IC

更新日期：2007-03-01 00:00:00

abstract：:From the stem bark of Strychnos malacoclados, one new bisindole alkaloid, 3-hydroxylongicaudatine Y (1), was isolated along with the known alkaloids vomicine (2), bisnordihydrotoxiferine (3), divarine (4), longicaudatine (5), longicaudatine Y (6), and longicaudatine F (7). All the compounds were tested for their antim...

journal_title：Planta medica

authors： Tchinda AT,Ngono AR,Tamze V,Jonville MC,Cao M,Angenot L,Frédérich M

更新日期：2012-03-01 00:00:00

abstract：:Rhapontin was purified from a methanol extract from the roots of Rheum undulatum, and rhapontigenin was produced by an enzymatic transformation of rhapontin. Rats were fed a high-cholesterol diet to induce hyperlipidemia, followed by oral treatment with rhapontin or rhapontigenin (1-5 mg/kg/day). Rhapontin and rhapont...

journal_title：Planta medica

authors： Jo SP,Kim JK,Lim YH

更新日期：2014-08-01 00:00:00

abstract：:Teak ( Tectona grandis L.f., Verbenaceae) sawdust extract inhibited the growth of Aspergillus niger. Centrifugal partition chromatography was used to isolate the active compounds. By (1)H-NMR the active compounds were identified as deoxylapachol and tectoquinone. Two A. niger transgenic strains which show induction of...

journal_title：Planta medica

authors： Sumthong P,Damveld RA,Choi YH,Arentshorst M,Ram AF,van den Hondel CA,Verpoorte R

更新日期：2006-08-01 00:00:00

abstract：:We have examined the immunosuppressive effects of representative ginsenosides (Rb1, Rb2, Re and Rg1) from Panax ginseng C. A. Meyer on CD4+ and CD8+ lymphocyte proliferation. Ginsenosides differentially modulated lymphocyte proliferation induced by concanavalin A (Con A), lipopolysaccharide (LPS), phytohemaglutinin (P...

journal_title：Planta medica

authors： Cho JY,Kim AR,Yoo ES,Baik KU,Park MH

更新日期：2002-06-01 00:00:00

abstract：:Callus extracts of Crocus sativus exhibited the ability to transform all-trans-crocetin into its related glycosides between pH 7.0 and 7.6 in the presence of uridine-diphospho-glucose. The reactions involved the step-wise addition of a glucose moiety to a free carboxyl function and the 1-->6 addition of a glucose moie...

journal_title：Planta medica

authors： Dufresne C,Cormier F,Dorion S

更新日期：1997-04-01 00:00:00

abstract：:A radioimmunoassay as well as an enzyme immunoassay for the quantitation of fmol amounts of the alkaloid colchicine have been developed. The antiserum used for both assays was raised against a conjugate of colchicoside-bovine serum albumin. The crude serum was satisfactory for the performance of the radioimmunoassay. ...

journal_title：Planta medica

authors： Poulev A,Deus-Neumann B,Bombardelli E,Zenk MH

更新日期：1994-02-01 00:00:00

abstract：:The investigation of the roots and aerial parts of EUPATORIUM CANNABIUM afforded, in addition to the sesquiterpene lactones eupatolide, eupatoriopicrin, and eucannabinolide isolated previously, eight further lactones, three of which are new. Furthermore, in addition to known compounds, a new clerodane derivative and t...

journal_title：Planta medica

authors： Zdero C,Bohlmann F

更新日期：1987-04-01 00:00:00

abstract：:We report the effects of a fraction (F1) obtained from Himanthalia elongata on spontaneous locomotor activity, hypermotility, motor coordination, rectal temperature, pentobarbitone-induced hypnosis, pentylenetetrazole-induced convulsions and analgesic activity in the writhing and hot-plate tests. This fraction caused ...

journal_title：Planta medica

authors： Anca JM,Lamela M,Calleja JM

更新日期：1993-06-01 00:00:00

abstract：:Eleven sesquiterpenoids have been isolated from the whole plants of Youngia japonica (Asteraceae). Among these sesquiterpenoids, five were identified as new compounds on the basis of spectroscopic methods and chemical analysis. Their structures were 3-oxo-8alpha-(4-hydoxyphenyl)acetoxy-10(14),11(13)-guaiadien-12,6-oli...

journal_title：Planta medica

authors： Chen W,Liu Q,Wang J,Zou J,Meng D,Zuo J,Zhu X,Zhao W

更新日期：2006-02-01 00:00:00

abstract：:Dioscoretine isolated from the aqueous fraction of the methanol extract of Dioscorea dumetorum tubers when administered intra-peritoneally to normal and alloxan diabetic rabbits produces significant hypoglycaemic effects at a dose of 20 mg/kg. The fasting blood sugar in normoglycaemic rabbits was reduced from 112 mg/1...

journal_title：Planta medica

authors： Iwu MM,Okunji CO,Ohiaeri GO,Akah P,Corley D,Tempesta MS

更新日期：1990-06-01 00:00:00

abstract：:The species Ageratina pichinchensis (Asteraceae) has been used for a long time in Mexican traditional medicine for the treatment of different skin conditions and injuries. In this study, the healing capacity of the plant extracts obtained was evaluated and, in order to understand the mechanism of healing, we also anal...

journal_title：Planta medica

authors： Romero-Cerecero O,Zamilpa-Álvarez A,Ramos-Mora A,Alonso-Cortés D,Jiménez-Ferrer JE,Huerta-Reyes ME,Tortoriello J

更新日期：2011-07-01 00:00:00

abstract：:In an attempt to induce positive effects on the acclimatization of in vitro propagated Echinacea pallida, four arbuscular mycorrhizal (AM) fungi, Glomus mosseae, Gigaspora ramisporophora, Scutellospora fulgida and Entrophospora colombiana were selected to aid the soil adaptation process. Fungal inocula affected the su...

journal_title：Planta medica

authors： Lata H,De Andrade Z,Schaneberg B,Bedir E,Khan I,Moraes R

更新日期：2003-07-01 00:00:00

abstract：:Angelicae Sinensis Radix is commonly used in traditional Chinese medicine. Pharmacological studies show that Angelicae Sinensis Radix has clear anticoagulant activity. Therefore, in this study, the anticoagulant activity of crude Angelicae Sinensis Radix extracts was investigated by measuring the thrombin times of the...

journal_title：Planta medica

authors： Wang L,Huang S,Chen B,Zang XY,Su D,Liang J,Xu F,Liu GX,Shang MY,Cai SQ

更新日期：2016-03-01 00:00:00

abstract：:The involvement of unfolded protein response (UPR) activation in tumor survival and resistance to chemotherapies suggests a new anticancer strategy targeting UPR pathway. Arctigenin, a natural product, has been recently identified for its antitumor activity with selective toxicity against cancer cells under glucose st...

journal_title：Planta medica

authors： Sun S,Wang X,Wang C,Nawaz A,Wei W,Li J,Wang L,Yu DH

更新日期：2011-01-01 00:00:00

abstract：:EGFR, as a critical signaling pathway in many human tumors, has become an important target of cancer drug design. Taspine has shown meaningful angiogenesis activity in previous studies. This paper is to investigate the antitumor action of taspine by modulating the EGFR signaling pathway. The study determined the expre...

journal_title：Planta medica

authors： Zhang Y,Zheng L,Zhang J,Dai B,Wang N,Chen Y,He L

更新日期：2011-11-01 00:00:00

abstract：:Bryophyllum pinnatum is a succulent perennial plant native to Madagascar which is used in anthroposophical medicine to treat psychiatric disorders and as a tocolytic agent to prevent premature labour. We performed a metabolite profiling study in order to obtain a comprehensive picture of the constituents in B. pinnatu...

journal_title：Planta medica

authors： Fürer K,Raith M,Brenneisen R,Mennet M,Simões-Wüst AP,von Mandach U,Hamburger M,Potterat O

更新日期：2013-11-01 00:00:00

abstract：:Cell lines that were highly productive for berberine were selected by repeated cloning of small cell aggregates. The berberine content of the highest-producing cell line increased after 4 clonings to 10% dw in comparison to the 3% dw found for the parent line, and the berberine yield was about 1,500 mg/1/14 days. Ther...

journal_title：Planta medica

authors： Hara Y,Yamagata H,Morimoto T,Hiratsuka J,Yoshioka T,Fujita Y,Yamada Y

更新日期：1989-04-01 00:00:00

abstract：:Ten alkaloids were isolated from the bulb of CORYDALIS HSUCHOWENSIS W. Y. Lian nov. ined. Among them nine alkaloids are known, identified as (-)-stylopine ( 1), cheilanthifoline ( 2), (+)-adlumidine ( 3), (+)-bicuculline ( 4), sibiricine ( 5), humosine A ( 6), (+)-bulbocapnine ( 7), (-)-scoulerine ( 8), and protopine ...

journal_title：Planta medica

authors： Zhou JY,Tong XJ,Lian WY,Fang QC

更新日期：1991-04-01 00:00:00

abstract：:A new isoprenylated xanthone, cudrafrutixanthone A, was isolated from the roots of Cudrania fruticosa, together with 18 known compounds. Their structures were elucidated by spectroscopic methods. Most isoprenylated xanthones exhibited cytotoxicity against HCT-116, SMMC-7721, SGC-7901, and BGC-823 cell lines with IC (5...

journal_title：Planta medica

authors： Wang YH,Hou AJ,Zhu GF,Chen DF,Sun HD

更新日期：2005-03-01 00:00:00

abstract：:The composition of the phthalide mixture of the essential oil from roots of Levisticum officinale Koch was investigated. The phthalide mixture was analyzed by combining separation methods - GLC, LSC and TLC - and subsequently using spectroscopic methods - IR, MS and NMR. E- and Z-butylidenephthalide, E- and Z-ligustil...

journal_title：Planta medica

authors： Gijbels MJ,Scheffer JJ,Baerheim Svendsen A

更新日期：1982-04-01 00:00:00

abstract：:The chemical analyses of two Cynara species: C. humilis and C.cornigera revealed various combinations of flavones, flavonols, flavanones, coumarins, phenolic acids, and an aurone. All the identified constituents are reported for the first time from the two species, while the presence of the aurone is reported for the ...

journal_title：Planta medica

authors： Chinou I,Harvala C

更新日期：1997-10-01 00:00:00