Antiplasmodial alkaloids from the stem bark of Strychnos malacoclados.

abstract：:The new diterpenoids, candesalvoquinone, 12- O-methylcandesalvone B, candesalvone B methyl ester with the 3,4-secoabietane skeleton, and candelabroquinone with the abietane skeleton were isolated from the aerial parts of Salvia candelabrum, together with the known compound candelabrone. The structures were established...

journal_title：Planta medica

authors： Hohmann J,Janicsák G,Forgo P,Rédei D,Máthé I,Bartók T

更新日期：2003-03-01 00:00:00

abstract：:Recently, an increasing number of pharmacists had to supply medicinal products based on Cannabis sativa L. (Cannabaceae), prescribed by physicians to individual patients. Cannabis olive oil preparation is the first choice as a concentrated extract of cannabinoids, even though standardized operative conditions for obta...

journal_title：Planta medica

authors： Casiraghi A,Roda G,Casagni E,Cristina C,Musazzi UM,Franzè S,Rocco P,Giuliani C,Fico G,Minghetti P,Gambaro V

更新日期：2018-03-01 00:00:00

abstract：:The phenylpropanoid dibenzylbutyrolactone lignan arctigenin, a key component found in Arctium lappa, or burdock, has been reported with a variety of therapeutic effects including anticancer, anti-inflammation, and antivirus effects. Using LC/MS/MS, three novel metabolites of arctigenin, namely, arctigenic acid, arctig...

journal_title：Planta medica

authors： Gao Q,Zhang Y,Wo S,Zuo Z

更新日期：2013-04-01 00:00:00

abstract：:Urinary metabolites of scutellarin, the main effective constituent of breviscapine, a cerebrovascular and cardiovascular drug consisting of total flavonoids of Erigeron breviscapus, were investigated in rats. Two major metabolites were isolated from the urine of rats following oral administration of scutellarin and id...

journal_title：Planta medica

authors： Qiu F,Xia H,Zhang T,Di X,Qu G,Yao X

更新日期：2007-04-01 00:00:00

abstract：:The natural compound tyropeptin A, a new peptidyl aldehyde proteasome inhibitor, was tested for its trypanocidal activity in vitro using culture-adapted bloodstream forms of Trypanosoma brucei. The concentrations of tyropeptin A required to reduce the growth rate by 50 % and to kill all cells were 10 and 100 times low...

journal_title：Planta medica

authors： Steverding D,Pemberton AJ,Royle H,Spackman RW,Rivett AJ

更新日期：2006-06-01 00:00:00

abstract：:Halimium halimifolium (Hh) is a shrub used in Algerian folk medicine to treat gastrointestinal pain. An UHPLC-PDA-ESI/MSn method was developed to identify the metabolic profile of the traditionally used infusion (Hh-A) from the aerial parts. The structures of flavanols were confirmed by NMR analysis after the isolatio...

journal_title：Planta medica

authors： Kerbab K,Sansone F,Zaiter L,Esposito T,Celano R,Franceschelli S,Pecoraro M,Benayache F,Rastrelli L,Picerno P,Aquino RP,Mencherini T

更新日期：2019-08-01 00:00:00

abstract：:The antiviral activities of two saponins, soyasaponin I and II, isolated from soybean (Glycine max Merrill) were studied in vitro against herpes simplex virus type 1 (HSV-1). Soyasaponin II was more potent than soyasaponin I as shown by reduction of HSV-1 production. Soyasaponin II was also found to inhibit the replic...

journal_title：Planta medica

authors： Hayashi K,Hayashi H,Hiraoka N,Ikeshiro Y

更新日期：1997-04-01 00:00:00

abstract：:Tuberculosis, also called TB, is currently a major health hazard due to multidrug-resistant forms of bacilli. Global efforts are underway to eradicate TB using new drugs with new modes of action, higher activity, and fewer side effects in combination with vaccines. For this reason, unexplored new sources and previousl...

journal_title：Planta medica

authors： Santhosh RS,Suriyanarayanan B

更新日期：2014-01-01 00:00:00

abstract：:The known alkaloids (+/-)-stylopine, (+/-)-sinactine, protopine, (+)-bulbocapnine, (-)-domesticine, (+)-corydine and (+)-isoboldine were found in the mixture of alkaloids from Corydalis marschalliana (Papaveraceae), growing in Bulgaria. The alkaloids dehydronantenine, (+)-nantenine and oxonantenine were isolated for t...

journal_title：Planta medica

authors： Kiryakov HG,Iskrenova E,Kuzmanov B,Evstatieva L

更新日期：1981-03-01 00:00:00

abstract：:The ethanolic extract of Ilex aquifolium L. (Aquifoliaceae) concentration-dependently inhibited leukotriene B4 biosynthesis in isolated bovine PMNL with an IC50 value of about 60 micrograms/ml, whereas the effect on epidermal 12(S)-HETE biosynthesis was much less pronounced. The extract also inhibited the non-enzymati...

journal_title：Planta medica

authors： Müller K,Ziereis K,Paper DH

更新日期：1998-08-01 00:00:00

abstract：:Besides the known pyrrolidine alkaloids ruspolinone ( 1), norruspolinone ( 2), and norruspoline ( 3) the "bispyrrolidine" alkaloid hypercratine was isolated from the roots of RUSPOLIA HYPERCRATERIFORMIS M. R. (Acanthaceae). After chemical and spectroscopic analysis of the new compound, structure 4 is suggested. ...

journal_title：Planta medica

authors： Neukomm G,Roessler F,Johne S,Hesse M

更新日期：1983-08-01 00:00:00

abstract：:The flower buds of Lonicera japonica are widely used in Chinese medicine for their anti-inflammatory properties. The reason why L. japonica has potent and significant effects is that it contains various active components, especially chlorogenic acid (CGA). In the present study, we isolated a hydroxycinnamoyl-CoA quina...

journal_title：Planta medica

authors： Peng X,Li W,Wang W,Bai G

更新日期：2010-11-01 00:00:00

abstract：:Agastache mexicana is a plant in high demand that has long been used in Mexican folk medicine to treat anxiety, insomnia, and stomachache, among other afflictions. Ursolic acid and acacetin were isolated and identified as two possible active compounds of A. mexicana aerial parts. An antinociceptive response was demons...

journal_title：Planta medica

authors： González-Trujano ME,Ventura-Martínez R,Chávez M,Díaz-Reval I,Pellicer F

更新日期：2012-05-01 00:00:00

abstract：:A simultaneous separation of the enantiomers of kawain, dihydrokawain, methysticin, and dihydromethysticin as well as the achiral dienolides yangonin and demethoxyyangonin was carried out on a ChiraSpher NT column. This HPLC method can be used for the investigation of the enantiomeric purity of plant material and herb...

journal_title：Planta medica

authors： Häberlein H,Boonen G,Beck MA

更新日期：1997-02-01 00:00:00

abstract：:The effects of the essential oil of Mentha pulegium L. (EOMP), a plant commonly known as "pennyroyal" or "poejo" that is used in folk medicine as an abortifaceant, were assessed on the isolated rat myometrium. Myometrial strips were stimulated with 10 nM oxytocin or 10 microM PGF (2alpha). EOMP (10 - 300 microg/mL) co...

journal_title：Planta medica

authors： Soares PM,Assreuy AM,Souza EP,Lima RF,Silva TO,Fontenele SR,Criddle DN

更新日期：2005-03-01 00:00:00

abstract：:Qianhu, the dried roots of Peucedanum praeruptorum, is a well-known traditional Chinese medicinal herb which was officially listed in the Chinese Pharmacopoeia. Praeruptorin A is the major active constituent of Qianhu. Our previous studies show that praeruptorin effectively transactivated the protein expression and ca...

journal_title：Planta medica

authors： Huang L,Bi HC,Li YH,Zhang JQ,Kuang SY,Zhang L,Wang YT,Huang M

更新日期：2013-11-01 00:00:00

abstract：:Human vascular endothelial cells (HUVECs) were exposed to CoCl2 as an in vitro model of hypoxia. Expression of VCAM-1 (vascular cell adhesion molecule), reduction of PECAM-1 (platelet endothelial cell adhesion molecule) and cytoskeletal changes without alterations in cell viability were observed. HUVECs were also expo...

journal_title：Planta medica

authors： Montopoli M,Froldi G,Comelli MC,Prosdocimi M,Caparrotta L

更新日期：2007-03-01 00:00:00

abstract：:Amyloid-β, one of the hallmarks of Alzheimer's disease, is toxic to neurons and causes cell death in the brain. Oxidative stress is known to play an important role in Alzheimer's disease, and there is strong evidence linking oxidative stress to amyloid-β. The herbal plant "Tiew kon" (Cratoxylum formosum ssp. pruniflor...

journal_title：Planta medica

authors： Keowkase R,Weerapreeyakul N

更新日期：2016-04-01 00:00:00

abstract：:Thyme extract is known to posses spasmolytic effects on isolated trachea and to increase ciliary activity. A small part of this effect is mediated via beta (2) receptors, but other receptors are supposed to be involved. Endothelin has a pathophysiological impact in asthma with respect to hyper-reagibility and contract...

journal_title：Planta medica

authors： Engelbertz J,Schwenk T,Kinzinger U,Schierstedt D,Verspohl EJ

更新日期：2008-10-01 00:00:00

abstract：:Myrrh is the oleo-gum resin of mainly Commiphora molmol and as a powdered substance, one compound in the traditional medicinal product Myrrhinil-Intest®, which has been used for the treatment of unspecific, inflammatory intestinal disorders. The aim of the present study was to evaluate the antispasmodic effect of myrr...

journal_title：Planta medica

authors： Vissiennon C,Goos KH,Goos O,Nieber K

更新日期：2015-01-01 00:00:00

abstract：:Antioxidants such as vitamin E may act differently on skin cells depending on the age of the skin and the level of oxidative damage induced. The effects of alpha-tocopherol (ATF) on H(2)O(2)-induced DNA damage and telomere shortening of normal human skin fibroblast cells derived from young and old individual donors we...

journal_title：Planta medica

authors： Makpol S,Zainuddin A,Rahim NA,Yusof YA,Ngah WZ

更新日期：2010-06-01 00:00:00

abstract：:Oxygen radical injury and lipid peroxidation have been suggested as major causes of atherosclerosis, cancer, liver disease, and the aging process. More specifically, oxidative modification of low density lipoprotein (LDL) has been recognized as an important process of atherosclerosis. In this study, we determined the ...

journal_title：Planta medica

authors： Ide N,Nelson AB,Lau BH

更新日期：1997-06-01 00:00:00

abstract：:Stellera chamaejasme, also known as "Langdu", has been traditionally used for the management of skin-related diseases such as psoriasis and skin ulcers. The aim of this study was to determine whether S. chamaejasme and its major component, luteolin 7-O-glucoside, have a preventive effect on the development of atopic d...

journal_title：Planta medica

authors： Jo BG,Park NJ,Jegal J,Choi S,Lee SW,Yi LW,Kim SN,Yang MH

更新日期：2019-05-01 00:00:00

abstract：:Usnic acid, a lichen secondary metabolite produced by a whole number of lichens, has attracted the interest of researchers owing to its broad range of biological activity, including antiviral, antibiotic, anticancer properties, and it possessing a certain toxicity. The synthesis of new usnic acid derivatives and the i...

journal_title：Planta medica

authors： Dyrkheeva N,Luzina O,Filimonov A,Zakharova O,Ilina E,Zakharenko A,Kuprushkin M,Nilov D,Gushchina I,Švedas V,Salakhutdinov N,Lavrik O

更新日期：2019-01-01 00:00:00

abstract：:Four new iridoids viz., plumeridoids A, B, and C and epiplumeridoid C were isolated from the stem bark of Plumeria rubra Linn. together with twenty-four known compounds viz., 1-( P-hydroxyphenyl)propan-1-one, isoplumericin, plumericin, dihydroplumericin, allamcin, fulvoplumerin, allamandin, plumieride, P- E-coumaric a...

journal_title：Planta medica

authors： Kuigoua GM,Kouam SF,Ngadjui BT,Schulz B,Green IR,Choudhary MI,Krohn K

更新日期：2010-04-01 00:00:00

abstract：:The flowers of ARNICA MOLLIS afforded, in addition to baileyin ( 1A), baileyin acetate ( 1B), xanthalongin ( 3), and 2-deacetoxy-11alpha,13-dihydroxanthuminol ( 6), the new 1,5- CIS-guaianolides arnimollin acetate ( 2A) and arnimollin tiglinate ( 2A) and the new xanthanolides 11beta3,13-dihydroxanthalongin ( 4) and 11...

journal_title：Planta medica

authors： Marcinek-Hüpen-Bestendonk C,Willuhn G,Steigel A,Wendisch D,Middelhauve B,Wiebcke M,Mootz D

更新日期：1990-02-01 00:00:00

abstract：:A new eudesmanolide sesquiterpene, sivasinolide 6-O-angelate (1), was isolated from the aerial parts of Anthemis ruthenica together with the known compounds chrysanin (2), tanacin (3), 3 beta-hydroxycostunolide (4), centauridin (5), and centaureidin (6). The compounds were obtained by means of bioactivity-guided fract...

journal_title：Planta medica

authors： Hajdú Z,Zupkó I,Réthy B,Forgo P,Hohmann J

更新日期：2010-01-01 00:00:00

abstract：:Three new tetrahydroprotoberberine N-oxide alkaloids, (-)- cis-corydalmine N-oxide, (-)- trans-corydalmine N-oxide, and (-)- trans-isocorypalmine N-oxide, along with three known benzo[ C]phenanthridine alkaloids, norsanguinarine, dihydrosanguinarine, and oxysanguinarine, six known berberine alkaloids, (-)-tetrahydropa...

journal_title：Planta medica

authors： Chen JJ,Duh CY,Chen IS

更新日期：1999-10-01 00:00:00

abstract：:Seven new clerodane diterpenoids, dysoxydensins A-G (1-7), together with six known clerodanes, were isolated from Dysoxylum densiflorum. The structures of all the compounds were elucidated by extensive spectroscopic analysis. These compounds were evaluated for their cytotoxic activities against five human cancer cell ...

journal_title：Planta medica

authors： Gu J,Cheng GG,Qian SY,Li Y,Liu YP,Luo XD

更新日期：2014-08-01 00:00:00

abstract：:During activity-guided fractionations to screen for antineoplastic agents, further studies by means of preparative HPLC led to the isolation of four known furostanol saponins: protoneodioscin, protodioscin, protoneogracillin, protogracillin, along with their corresponding artifacts: methyl protoneodioscin, methyl prot...

journal_title：Planta medica

authors： Hu K,Dong A,Yao X,Kobayashi H,Iwasaki S

更新日期：1997-04-01 00:00:00