Modified Aloe barbadensis polysaccharide with immunoregulatory activity.

Abstract:

:Aloe barbadensis polysaccharide was partially digested with cellulase and further purified by dialysis, stepwise ethanol precipitation, and size exclusion chromatography. Crude modified Aloe polysaccharide (MAP) activated macrophage cells and stimulated fibroblast growth. Under the same conditions, native Aloe barbadensis gel had no effect on macrophage activation. MAP prevented ultraviolet B (UVB) irradiation-induced immune suppression as determined by contact hypersensitivity (CHS) response in C3H/HeN mice. This in vivo activity was correlated with the activity of MAP to inhibit UVB irradiation-induced tumor necrosis factor alpha (TNF-alpha) release from human epidermoid carcinoma cells (KB cells). MAP with an average molecular weight of 80,000 Dalton (Da) contained mannose, galactose, and glucose in a ratio of 40:1.4:1.0. MAP was likely a linear, highly acetylated molecule.

journal_name

Planta Med

journal_title

Planta medica

authors

Qiu Z,Jones K,Wylie M,Jia Q,Orndorff S

doi

10.1055/s-2000-11125

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

152-6

issue

2

eissn

0032-0943

issn

1439-0221

journal_volume

66

pub_type

杂志文章
  • An arabinogalactan-protein from cell culture of Malva sylvestris.

    abstract::An arabinogalactan-protein (AGP) from suspension culture medium of Malva sylvestris was isolated by precipitation with beta-glucosyl Yariv reagent, followed by gel-permeation chromatography. It revealed characteristic features of AGPs: a high amount of polysaccharide with a ratio of galactose to arabinose of 1.9 : 1, ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2002-23127

    authors: Classen B,Blaschek W

    更新日期:2002-03-01 00:00:00

  • Antiproliferative effects on tumour cells and promotion of keratinocyte wound healing by different lichen compounds.

    abstract::Five compounds representative of major structural classes of lichen polyketides, VIZ. (+)-usnic (1), salazinic (2), vulpinic (3), gyrophoric (4), and evernic acids (5), were investigated for their ability to affect cell proliferation or wound healing, two functional targets of relevance for research on cancer or tissu...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0029-1185329

    authors: Burlando B,Ranzato E,Volante A,Appendino G,Pollastro F,Verotta L

    更新日期:2009-05-01 00:00:00

  • Activity of quinones from teak (Tectona grandis) on fungal cell wall stress.

    abstract::Teak ( Tectona grandis L.f., Verbenaceae) sawdust extract inhibited the growth of Aspergillus niger. Centrifugal partition chromatography was used to isolate the active compounds. By (1)H-NMR the active compounds were identified as deoxylapachol and tectoquinone. Two A. niger transgenic strains which show induction of...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-946676

    authors: Sumthong P,Damveld RA,Choi YH,Arentshorst M,Ram AF,van den Hondel CA,Verpoorte R

    更新日期:2006-08-01 00:00:00

  • Essential oil composition and antimicrobial activity of three Zingiberaceae from S.Tomé e Príncipe.

    abstract::The essential oil composition of three Zingiberaceae widely used as medicinal aromatic plants from S. Tomé and Príncipe: Aframomum danielli (Hook. f.) K. Schum., Curcuma longa L. and Zingiber officinale Rosc. was studied. Two samples of the essential oils from fruit of A. danielli and from rhizomes of the other two sp...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2001-16494

    authors: Martins AP,Salgueiro L,Gonçalves MJ,da Cunha AP,Vila R,Cañigueral S,Mazzoni V,Tomi F,Casanova J

    更新日期:2001-08-01 00:00:00

  • Cryopreservation of Digitalis obscura selected genotypes by encapsulation-dehydration.

    abstract::Shoot-tips from several genotypes of the cardenolide-producing perennial shrub Digitalis obscura L. were successfully cryopreserved using the encapsulation-dehydration technique. Precultivation on MS medium containing 0.5 M sucrose, followed by 2.5 h dehydration (final weight 30 %) induced shoot regrowth in 42 % of cr...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2001-18861

    authors: Sales E,Nebauer SG,Arrillaga I,Segura J

    更新日期:2001-12-01 00:00:00

  • Chemical constituents from the stem bark of Trewia nudiflora L. and their antioxidant activities.

    abstract::Three new compounds, namely, (+)-dihydrodehydrodiconiferyl alcohol 4- O- beta-(6''- O-galloyl)-glucopyranoside ( 1), 4,4'- O-dimethylellagic acid 3-(2''- O-acetyl)- alpha-rhamnopyranoside ( 2), and ethyl O- beta-(6'-galloyl)-glucopyranoside ( 3), together with eleven known ones, were isolated from the stem bark of Tre...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034361

    authors: Kang QJ,Yang XW,Wu SH,Ma YL,Li L,Shen YM

    更新日期:2008-03-01 00:00:00

  • In vitro effects of Panax ginseng in aristolochic acid-mediated renal tubulotoxicity: apoptosis versus regeneration.

    abstract::This in vitro study aimed to determine the effects of a Panax ginseng extract on aristolochic acid-mediated toxicity in HK-2 cells. A methanolic extract of ginseng (50 µg/mL) was able to reduce cell survival after treatment with 50 µM aristolochic acid for 24, 48, and 72 h, as evidenced by a resazurin reduction assay....

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0035-1545839

    authors: Bunel V,Antoine MH,Nortier J,Duez P,Stévigny C

    更新日期:2015-03-01 00:00:00

  • Antiviral Activity of Crude Hydroethanolic Extract from Schinus terebinthifolia against Herpes simplex Virus Type 1.

    abstract::Herpes simplex virus infections persist throughout the lifetime of the host and affect more than 80 % of the humans worldwide. The intensive use of available therapeutic drugs has led to undesirable effects, such as drug-resistant strains, prompting the search for new antiherpetic agents. Although diverse bioactivitie...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0042-117774

    authors: Nocchi SR,Companhoni MV,de Mello JC,Dias Filho BP,Nakamura CV,Carollo CA,Silva DB,Ueda-Nakamura T

    更新日期:2017-04-01 00:00:00

  • Effect of gomisin A in an immunologically-induced acute hepatic failure model.

    abstract::Guinea pigs were sensitized with trinitrophenylated liver macromolecular protein fraction (TNP-LP1) prepared by using sodium trinitrobenzenesulfonate of strong immunogenicity as the hapten and LP1 as the carrier protein. The administration of trinitrophenylated hepatocytes and lipopolysaccharide to these TNP-LP1-sensi...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-960006

    authors: Mizoguchi Y,Shin T,Kobayashi K,Morisawa S

    更新日期:1991-02-01 00:00:00

  • Two new beta-carboline alkaloids from Hedyotis capitellata var. mollis.

    abstract::Two new beta-carboline alkaloids, hedyocapitelline and hedyocapitine, were isolated from Hedyotis capitellata var. mollis (Rubiaceae). Their structures were elucidated by spectroscopic data (1)H- and (13)C-NMR, MS, IR, UV). ...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2006-960861

    authors: Phuong NM,Van Sung T,Porzel A,Schmidt J,Adam G

    更新日期:1999-12-01 00:00:00

  • Effects of Phaeodactylum tricornutum and Dunaliella tertiolecta extracts on the central nervous system.

    abstract::We report the effects of aqueous extracts of the microalgae Dunaliella tertiolecta Butcher (Chlorophyceae) and Phaeodactylum tricornutum Bohlin (Bacillariophyceae) on oxotremorin-induced cholinergic symptoms, amphetamine-induced hypermotility, pentylenetetrazole-induced convulsions, and Rota-rod test performance. Both...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-960914

    authors: Laguna MR,Villar RM,Cadavid I,Calleja JM

    更新日期:1990-04-01 00:00:00

  • Goji (Lycium barbarum and L. chinense): Phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity.

    abstract::Since the beginning of this century, Goji berries and juice are being sold as health food products in western countries and praised in advertisements and in the media for well-being and as an anti-aging remedy. The popularity of Goji products has rapidly grown over the last years thanks to efficient marketing strategi...

    journal_title:Planta medica

    pub_type: 杂志文章,评审

    doi:10.1055/s-0029-1186218

    authors: Potterat O

    更新日期:2010-01-01 00:00:00

  • Targeted and untargeted phytochemistry of Ligusticum canbyi: indoleamines, phthalides, antioxidant potential, and use of metabolomics as a hypothesis-generating technique for compound discovery.

    abstract::Ligusticum canbyi (J.M. Coult & Rose) is a medicinal understory forest species used in traditional rituals and ceremonies for spiritual enlightenment and improved mental health. Very little is known about the phytochemical complexity or diversity of L. canbyi tissues or extracts. The current study was undertaken to de...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0033-1350618

    authors: Turi CE,Murch SJ

    更新日期:2013-09-01 00:00:00

  • GABA(A) receptor modulators from the Chinese herbal drug Junci Medulla--the pith of Juncus effusus.

    abstract::The gamma-amino butyric acid (GABA) type A (GABA(A)) receptor represents a crucial target for clinical agents in the treatment of anxiety and insomnia. Using the two-microelectrode voltage clamp technique on recombinant α₁β₂γ(2S) GABA (A) receptors, effusol (1) and dehydroeffusol (2) were isolated in a bioactivity-gui...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0031-1298174

    authors: Singhuber J,Baburin I,Khom S,Zehl M,Urban E,Hering S,Kopp B

    更新日期:2012-03-01 00:00:00

  • Biotransformation of 2alpha,5alpha,10beta,14beta-tetraacetoxy-4(20),11-taxadiene by cell suspension cultures of Catharanthus roseus.

    abstract::Catharanthus roseus cell suspension cultures were employed for the biotransformation of 2alpha,5alpha,10beta,14beta-tetraacetoxy-4(20),11-taxadiene ( 1), and four metabolites were obtained. Based on their physical and chemical data, the structures of the four metabolites were respectively elucidated as 10beta-hydroxy-...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2002-36340

    authors: Dai J,Cui Y,Zhu W,Guo H,Ye M,Hu Q,Zhang D,Zheng J,Guo D

    更新日期:2002-12-01 00:00:00

  • Growth of cultured human bronchiogenic epithelioid CCD-14 Br cells and dermal fibroblasts, NB1 RGB treated with ginseng tetrapeptide and its isomer.

    abstract::The configurations of the component amino acids in ginseng tetrapeptide 1 isolated from Panax ginseng were determined by HPLC with an optical resolution column and the structure of 1 was established to be H-L-Val-gamma-D-Glu-D-Arg- Gly-OH. Synthesis of the ginseng tetrapeptide, 1, and of the configuration and conjugat...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-957830

    authors: Yagi A,Ishizu T,Okamura N,Noguchi S,Itoh H

    更新日期:1996-04-01 00:00:00

  • Separation and determination of coumarins in the root bark of three citrus plants by micellar electrokinetic capillary chromatography.

    abstract::A micellar electrokinetic capillary chromatography (MEKC) method for the determination of xanthyletin and xanthoxyletin in the roots bark of three Citrus plants was developed for the first time. The electrophoresis buffer was 10 mmol/L sodium borate containing 50 mmol/L sodium dodecyl sulfate, 20% (v/v) acetonitrile a...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2003-39697

    authors: Wang SF,Ju Y,Chen XG,Hu ZD

    更新日期:2003-05-01 00:00:00

  • New guaiane sesquiterpene lactones from Ixeris dentata.

    abstract::Three new guaiane-type sesquiterpene lactones (1-3), together with nine related sesquiterpenes (4-12), were isolated from the whole extract of Ixeris dentata (Asteraceae). The chemical structures of isolates 1-12 were established by spectroscopic analyses as 3 β,8 β-dihydroxy-guaia-10(14)-en-1 α,4 α,5 α,6 β,7 α,11 βH-...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0030-1250369

    authors: Cha MR,Choi YH,Choi CW,Yoo DS,Kim YS,Choi SU,Kim YH,Ryu SY

    更新日期:2011-03-01 00:00:00

  • Eupatoriopicrin 19-O-Linolenoate and Other Constituents from Eupatorium cannabium.

    abstract::The investigation of the roots and aerial parts of EUPATORIUM CANNABIUM afforded, in addition to the sesquiterpene lactones eupatolide, eupatoriopicrin, and eucannabinolide isolated previously, eight further lactones, three of which are new. Furthermore, in addition to known compounds, a new clerodane derivative and t...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-962665

    authors: Zdero C,Bohlmann F

    更新日期:1987-04-01 00:00:00

  • Three new alkaloids from Galanthus nivalis and Galanthus elwesii.

    abstract::Phytochemical studies on Galanthus species resulted in the isolation of three new compounds: 3,3'-O-(3',3''-dihydroxybutanoyl)hamayne and 11,3'-O-(3',3''-dihydroxybutanoyl)hamayne from G. nivalis and 2-O-(3'-hydroxybutanoyl)lycorine from G. elwesii. Additionally, 3,11-O-(3',3''-dihydroxybutanoyl)hamayne, 3,11,3'-O-(3'...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-0029-1185575

    authors: Berkov S,Cuadrado M,Osorio E,Viladomat F,Codina C,Bastida J

    更新日期:2009-10-01 00:00:00

  • A simple and efficient separation of the curcumins, the antiprotozoal constituents of Curcuma longa.

    abstract::A simple and efficient method for the separation of the three phenolic diketones, curcumin 1, demethoxycurcumin 2, and bis-demethoxycurcumin 3, isolated from the rhizomes of Curcuma longa has been developed. The method is of general applicability for the separation of compounds containing acidic and chelating groups a...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2000-8533

    authors: Rasmussen HB,Christensen SB,Kvist LP,Karazmi A

    更新日期:2000-05-01 00:00:00

  • Hyphenated NMR methods in natural products research, part 1: direct hyphenation.

    abstract::This review describes the current status of the development of techniques combining liquid chromatography and nuclear magnetic resonance and their use in the context of natural products. HPLC-NMR methods have a rapidly growing impact on natural products research by enabling structure determination of natural products ...

    journal_title:Planta medica

    pub_type: 杂志文章,评审

    doi:10.1055/s-2005-871298

    authors: Jaroszewski JW

    更新日期:2005-08-01 00:00:00

  • Anti-inflammatory effect of kamebakaurin in in vivo animal models.

    abstract::We have identified kamebakaurin as an inhibitor of NF-KB and elucidated its molecular mechanism as a specific inhibitor in the DNA-binding activity of the p50 subunit of NF-KB. Here, we describe its anti-inflammatory activity in in vitro and in vivo models. Kamebakaurin dose-dependently inhibited not only the expressi...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2004-827152

    authors: Lee JH,Choi JK,Noh MS,Hwang BY,Hong YS,Lee JJ

    更新日期:2004-06-01 00:00:00

  • alpha-Glucosidase inhibitors from Commelina communis.

    abstract::A methanolic extract of Commelina communis showed potent inhibitory activity against alpha-glucosidase. One pyrrolidine alkaloid, 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine (DMDP, 1) and four piperidine alkaloids, 1-deoxymannojirimycin (2), 1-deoxynojirimycin (3), alpha-homonojirimycin (4) and 7-O-beta-D-glucopyrano...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2006-960803

    authors: Kim HS,Kim YH,Hong YS,Paek NS,Lee HS,Kim TH,Kim KW,Lee JJ

    更新日期:1999-06-01 00:00:00

  • Henricine, a New Tetrahydrofuran Lignan from Schisandra henryi.

    abstract::A new tetrahydrofuran lignan, named henricine ( 1), was isolated from the stems of SCHISANDRA HENRYI. High resolution COSY spectrum was used in the structural elucidation. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-969265

    authors: Lian-Niang L,Hong X

    更新日期:1986-12-01 00:00:00

  • Silyamandin, a new flavonolignan isolated from milk thistle tinctures.

    abstract::Our investigations into the stability of tincture preparations of milk thistle fruit [ Silybum marianum L. Gaertn. (Asteraceae)] have led to the characterization of a new flavonolignan 4-(4-hydroxy-3-methoxyphenyl)-7-[(2 R,3 R)-3,5,7-trihydroxy-4-oxochroman-2-yl]-1-oxo-1,3,3a,4,5,7a-hexahydro-2-benzofuran-5-carboxylic...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-981595

    authors: MacKinnon SL,Hodder M,Craft C,Simmons-Boyce J

    更新日期:2007-09-01 00:00:00

  • Further lignans from Saururus chinensis.

    abstract::Three new sauchinone analogues, sauchinones B-D (1-3), together with sauchinone (4), were isolated from the aerial part of Saururus chinensis. Structures of the new compounds were determined by extensive spectroscopic data as well as X-ray analysis. Compounds 3 and 4 inhibited nitric oxide production in lipopolysaccha...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0033-1351053

    authors: Gao X,He J,Wu XD,Peng LY,Dong LB,Deng X,Li Y,Cheng X,Zhao QS

    更新日期:2013-12-01 00:00:00

  • [On the gas-chromatographical determination of the pyrrolizidine alkaloids of some Senecio-species].

    abstract::A gas-chromatographical method is described on which seven pyrrolizidine alkaloids (Fuchsisenecionine, Senecionine, Senecivernine, Senkirkine, Retrorsine, O (7)-Angelylheliotridine and Heliotrine) are determinated in a qualitative way and their ratio of concentration in Senecio fuchsii, vernalis, inaequidens and ovire...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-971688

    authors: Wiedenfeld H,Pastewka U,Stengl P,Röder E

    更新日期:1981-02-01 00:00:00

  • Tea triterpenoidal saponins from the roots of Camellia sinensis have inhibitory effects against alcohol dehydrogenase.

    abstract::Ten new polyhydroxyolean-12-ene pentacyclic triterpenoidal saponins, named rogchaponins 1-10, were isolated from the methanolic extract of the roots of Camellia sinensis by a series of chromatographic methods (silica gel flash column and C18 MPLC followed by C18 HPLC). Their structures were established by 1D and 2D-NM...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0031-1280024

    authors: Varughese T,Manir MM,Rahaman M,Kim JK,Lee BG,Moon SS

    更新日期:2011-12-01 00:00:00

  • XVIII: Eperudiendiol, Glycerides and Neolignans from Fruits of Osteophloeum platyspermum1.

    abstract::The fruits of OSTEOPHLOEUM PLATYSPERMUM (Myristicaceae) contain sitosterol, eperu-8(20),13-dien-3alpha,15-diol, glyceryl laurodimyristate, glyceryl 1,3-lauromyristate and five neolignans: dihydroguaiaretic acid, hydroxyotobain, hydroxyoxootobain, guaiacin and otobaphenol. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-969620

    authors: Fo RB,de Carvalho MG,Gottlieb OR

    更新日期:1984-02-01 00:00:00