Abstract:
:In order to evaluate the potency of novel antiviral drugs, 11 natural sulfated polysaccharides (SPs) from 10 green algae ( Enteromorpha compressa, Monostroma nitidum, Caulerpa brachypus, C. okamurai, C. scapelliformis, Chaetomorpha crassa, C. spiralis, Codium adhaerens, C. fragille, and C. latum) and 4 synthetic sulfated xylans (SXs) prepared from the beta-(1,3)-xylan of C. brachypus, were assayed for anti-Herpes simplex virus type 1 (HSV-1) activity. Except for one from E. compressa, all SPs showed potent anti-HSV-1 activities with 50 % inhibitory concentrations (IC (50)) of 0.38 - 8.5 microg/mL, while having low cytotoxicities with 50 % inhibitory concentrations of >2900 microg/mL. Anti-HSV-1 activities of SXs were dependent on their degrees of sulfation. To delineate the drug-sensitive phase, 4 polysaccharides, which showed potent anti-HSV-1 activities, were applied to time-of-addition experiments. Among the polysaccharides tested, 3 polysaccharides (SX4, SP4 from C. brachypus, and SP11 from C. latum) showed strong anti-HSV-1 activities with IC (50) of 6.0, 7.5, and 6.9 microg/mL, respectively, even when added to the medium 8 h post-infection. These experiments demonstrated that some sulfated polysaccharides not only inhibited the early stages of HSV-1 replication, such as virus binding to and penetration into host cells, but also interfered with late steps of virus replication. These results revealed that some sulfated polysaccharides from green algae should be promising candidates of antiviral agents which might act on different stages in the virus replication cycle.
journal_name
Planta Medjournal_title
Planta medicaauthors
Lee JB,Hayashi K,Maeda M,Hayashi Tdoi
10.1055/s-2004-827228subject
Has Abstractpub_date
2004-09-01 00:00:00pages
813-7issue
9eissn
0032-0943issn
1439-0221journal_volume
70pub_type
杂志文章相关文献
PLANTA MEDICA文献大全abstract::Acetonylgeraniin, an active principle isolated from the seeds of Euphoria longana Lam. (Sapindaceae), reversed the fall in arterial blood pressure in conscious hypertensive rats (SHRs) with orthostatic hypotension induced by injection of hexamethonium into animals subjected to 90 degrees head-up tilts for 60 seconds. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-959487
更新日期:1994-08-01 00:00:00
abstract::High molecular compounds from Chinese herbal medicines, including ribosome-inactivating proteins and polysaccharides from both fungi and high plants have been tested for the treatment of malignant diseases. Polysaccharides possessing immunostimulating activities can be used as adjuvants in tumor treatment. The fungi c...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-2003-38494
更新日期:2003-03-01 00:00:00
abstract::The essential oils of Salvia ringens (samples A and B), were analyzed by means of GC and GC/MS. From the seventy-five identified constituents representing 99.82 and 99.86% of the oils, 1,8-cineole and alpha-pinene were the major components. Furthermore, sample B exhibited a very interesting antimicrobial profile after...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2001-10627
更新日期:2001-02-01 00:00:00
abstract::The quantification of free and total alkannins in 13 endemic Anatolian Alkanna species is described for the first time. Extraction of the samples was performed by sonication with hexane, followed by hydrolysis in 1 N NaOH. For analysis, a new HPLC method, utilizing reversed phase material (Synergi Max RP), was develop...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-967110
更新日期:2007-03-01 00:00:00
abstract::Ligusticum canbyi (J.M. Coult & Rose) is a medicinal understory forest species used in traditional rituals and ceremonies for spiritual enlightenment and improved mental health. Very little is known about the phytochemical complexity or diversity of L. canbyi tissues or extracts. The current study was undertaken to de...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0033-1350618
更新日期:2013-09-01 00:00:00
abstract::Callus extracts of Crocus sativus exhibited the ability to transform all-trans-crocetin into its related glycosides between pH 7.0 and 7.6 in the presence of uridine-diphospho-glucose. The reactions involved the step-wise addition of a glucose moiety to a free carboxyl function and the 1-->6 addition of a glucose moie...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-957633
更新日期:1997-04-01 00:00:00
abstract::Overexpression of the protein transporter P-glycoprotein (Pgp, MDR1) at the cell surface is a major cause of multidrug resistance (MDR) and poor response to treatment in cancer chemotherapy and therapy for leishmaniasis. The present study shows that conferone, a sesquiterpene coumarin ether isolated for the first time...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-931574
更新日期:2006-06-01 00:00:00
abstract::During the screening of antimalarial substances, the 80% EtOH extract from the outer bark of Ochna integerrima Merr. (Ochnaceae) was shown to have a good anti-malarial activity (IC50 value: 6.5 microg/mL) whereas extracts from the inner barks of O.integerrima showed no antimalarial activity. Biflavanone (1), which had...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-931569
更新日期:2006-06-01 00:00:00
abstract::Propolis is a cereus resin with a complex chemical composition that possesses a wide range of biological activities. The aim of this study was to evaluate the in vitro anti-Giardia lamblia activity of Sonoran propolis collected from three different areas of Sonoran Desert in northwestern Mexico (Caborca, Pueblo de Ala...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1545982
更新日期:2015-06-01 00:00:00
abstract::Fractionation of the aqueous extract of Derris scandens stems extract using tests for eicosanoid inhibition resulted in the isolation of three isoflavonoids, genistein, its 7- O-alpha-rhamno(1-->6)-beta-glucosyl glycoside, a new compound, and two known isoprenyl derivatives 3'-gamma,gamma-dimethylallylweighteone and s...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2004-827147
更新日期:2004-06-01 00:00:00
abstract::Six new triterpenoids including four new secodammarane triterpenoid glycosides (1-4), an epoxydammarane triterpenoid glycoside (5), and a new secodammarane triterpenoid (6) were isolated from the ethanolic extract of the leaves of Cyclocarya paliurus. The structures of these compounds were elucidated by spectroscopic ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1280411
更新日期:2012-02-01 00:00:00
abstract::Capillary GC, GC-MS, IR, GC-IR, (1)H- and (13)C-NMR studies of the essential oil from the leaves and cones of ELSHOLTZIA POLYSTACHYA collected from two different locations in India revealed that one oil contained 1,8-cineol (37.3%), the other one perillene (61.2%) as the main constituent. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-961490
更新日期:1992-08-01 00:00:00
abstract::Biosynthetic pathways of the essential oil components in PERILLA FRUTESCENS were examined by tracer experiments using [ (14)C]-labeled sucrose on two chemotypes: perillaketone (PK) and phenylpropanoid (PP-EM) types. The results of the experiments indicated that perillaketone is not converted from isoegomaketone but is...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-961996
更新日期:1989-06-01 00:00:00
abstract::Strictosidine synthase was partially purified from Catharanthus roseus cell suspension cultures and immobilized on CNBr-activated Sepharose. The immobilized enzyme exhibits a thermostability increased 300 fold over that of the soluble enzyme and catalyses exclusively the formation of the 3alpha(S)-isomer, strictosidin...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-970008
更新日期:1982-09-01 00:00:00
abstract::Transformed root cultures of ipecac (Cephaelis ipecacuanha A. Richard), one of the recalcitrant woody plant species for Agrobacterium-mediated transformation, were established by co-culturing of in vitro petiole segments with Agrobacterium rhizogenes ATCC 15 834. Southern blot analysis of the established roots reveale...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2003-45149
更新日期:2003-11-01 00:00:00
abstract::We investigated the apoptotic effects of the protopanaxadiol ginsenosides, Rb (1) and Rb (2), and their intestinal bacterial metabolite, 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol (M1), and of the protopanaxatriol ginsenoside, Rg (1), and its intestinal bacterial metabolite, 20(S)-protopanaxatriol, in activated ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-947223
更新日期:2006-10-01 00:00:00
abstract::The pharmacokinetics of huperzine A in dogs after single intravenous and oral administrations was investigated. Concentrations of huperzine A were determined by a validated liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. Pharmacokinetic parameters were calculated by non-compartmental methods. After s...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-931566
更新日期:2006-05-01 00:00:00
abstract::The antiinflammatory activity of borjatriol (a diterpenoid isolated from SIDERITIS MUGRONENSIS Borja) was tested using the cotton pellet-granuloma assay. The compound inhibited the granuloma weight and the serum lysozyme activity in a dose-dependently way. The determination of this enzyme has allowed us to distinguish...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969630
更新日期:1984-02-01 00:00:00
abstract::Capsaicin and 6-gingerol, pungent components of chilli pepper and ginger, are known as dietary agonists of transient receptor potential vanilloid-1. Transient receptor potential vanilloid-1 nerve fibers are recognized to play a role in gastric mucosal integrity in rats. In the present studies, we examined the acute ef...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1315387
更新日期:2012-11-01 00:00:00
abstract::From the bulbs of Vietnamese Hippeastrum equestre Herb. (Amaryllidaceae), besides the well known alkaloids lycorine, tazettine, and hippeastrine, a new alkaloid, phamine, has been isolated. Its structure was established by spectroscopic methods. ...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-959375
更新日期:1995-12-01 00:00:00
abstract::In this study, the significant hepatoprotective effect of dioscin against CCl₄-induced acute liver damage in mice was first discovered, and the effect produced by dioscin at the dose of 100 mg/kg was equal to the action produced by silymarin at the dose of 200 mg/kg. Then, 1-dimension gel electrophoresis was used to s...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0030-1250461
更新日期:2011-03-01 00:00:00
abstract::HPLC determinations of the aescin contents in calli and embryoids from leaf explants of AESCULUS HIPPOCASTANUM L. were carried out in order to determine whether it was possible to obtain aescin-forming proliferations IN VITRO. The results indicate that embryogenic calli and embryoids derived from them produce an amoun...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-960016
更新日期:1991-02-01 00:00:00
abstract::Eschsholzia californica Cham. is a traditional medicinal plant of the Indians used by the rural population of California for its analgesic and sedative properties. Our study on the aqueous extract shows that this plant reduced the behavioural parameters measured in a familiar environment test in mice (novelty preferen...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-960076
更新日期:1991-06-01 00:00:00
abstract::Plumbagin, an active principle from Plumbaginaceous plants, produced a triphasic inotropic response (first positive, second negative, and third positive phases) in guinea-pig papillary muscle. The inotropic potency of plumbagin at the first positive phase was pD2 6.40, and the methylation of 5-hydroxy group of plumbag...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-960106
更新日期:1991-08-01 00:00:00
abstract::Seven coumarins were isolated from the aerial parts of Tordylium apulum; their structures were established by spectroscopic means. All compounds were tested in vitro for their cytotoxicity against two cell line systems. The antiproliferative effects for three of them were studied at the level of the cell cycle in asyn...
journal_title:Planta medica
pub_type: 信件
doi:
更新日期:1998-03-01 00:00:00
abstract::The Mexican species GALPHIMIA GLAUCA (Cav.) Kuntze (Malphigiaceae) synthesises a family of sedative and anxiolytic nor-secofriedelanes, designated as galphimines. These active principles accumulate at low concentration in the aerial parts of plants from wild populations. Transformed calluses and cell suspension cultur...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0029-1186166
更新日期:2010-03-01 00:00:00
abstract::Two new coumaryloxy triterpenoids, neriucoumaric and isoneriucoumaric acids, have been isolated from fresh, undried and uncrushed leaves of NERIUM OLEANDER and their structures established as 3beta-hydroxy-2alpha-cis- P-coumaryloxy-urs-12-en-28-oic acid and 3beta-hydroxy-2alpha- TRANS- P-coumaryloxy-urs-12-en-28-oic a...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-962763
更新日期:1987-10-01 00:00:00
abstract::The aerial parts of DODONAEA VISCOSA afforded a new diterpenoid, dodonic acid, the structure and stereochemistry of which have been established by chemical and spectroscopic means. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969764
更新日期:1984-10-01 00:00:00
abstract::Four new phenanthroindolizidine alkaloids, tylophoridicines C-F, together with three known ones, R-(+)-deoxytylophorinidine, tylophorinine and tylophorinidine, were isolated from the roots of Tylophora atrofolliculata. The structures were determined on the basis of spectral evidence. These alkaloids exhibited cytotoxi...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2004-818973
更新日期:2004-05-01 00:00:00
abstract::Recently, we showed that intravenous (i.v.) treatment with the essential oil of Mentha x villosa (EOMV) in pentobarbitone-anaesthetised rats decreased blood pressure; the effect occurred independently of the presence of an operational central autonomic drive to the cardiovascular system. This finding suggested that th...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2002-33797
更新日期:2002-08-01 00:00:00