Abstract:
:Plumbagin, an active principle from Plumbaginaceous plants, produced a triphasic inotropic response (first positive, second negative, and third positive phases) in guinea-pig papillary muscle. The inotropic potency of plumbagin at the first positive phase was pD2 6.40, and the methylation of 5-hydroxy group of plumbagin reduced the potency. The triphasic pattern of inotropism of plumbagin was unaffected by reserpine or propranolol treatments. Plumbagin did not produce the positive inotropic effects under anoxic conditions or in the presence of mitochondrial oxidative phosphorylation inhibitors such as 2,4-dinitrophenol and dicumarol.
journal_name
Planta Medjournal_title
Planta medicaauthors
Itoigawa M,Takeya K,Furukawa Hdoi
10.1055/s-2006-960106subject
Has Abstractpub_date
1991-08-01 00:00:00pages
317-9issue
4eissn
0032-0943issn
1439-0221journal_volume
57pub_type
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