Cardiotonic action of plumbagin on guinea-pig papillary muscle.

Abstract:

:Plumbagin, an active principle from Plumbaginaceous plants, produced a triphasic inotropic response (first positive, second negative, and third positive phases) in guinea-pig papillary muscle. The inotropic potency of plumbagin at the first positive phase was pD2 6.40, and the methylation of 5-hydroxy group of plumbagin reduced the potency. The triphasic pattern of inotropism of plumbagin was unaffected by reserpine or propranolol treatments. Plumbagin did not produce the positive inotropic effects under anoxic conditions or in the presence of mitochondrial oxidative phosphorylation inhibitors such as 2,4-dinitrophenol and dicumarol.

journal_name

Planta Med

journal_title

Planta medica

authors

Itoigawa M,Takeya K,Furukawa H

doi

10.1055/s-2006-960106

subject

Has Abstract

pub_date

1991-08-01 00:00:00

pages

317-9

issue

4

eissn

0032-0943

issn

1439-0221

journal_volume

57

pub_type

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