Abstract:
:Natural products from fungi, especially Ascomycota, play a major role in therapy and drug discovery. Fungal strains originating from marine habitats offer a new avenue for finding unusual molecular skeletons. Here, the marine-derived fungus Epicoccum nigrum (strain 749) was found to produce the azaphilonoid compounds acetosellin and 5',6'-dihydroxyacetosellin. The latter is a new natural product. The biosynthesis of these polyketide-type compounds is intriguing, since two polyketide chains are assembled to the final product. Here we performed 13C labeling studies on solid cultures to prove this hypothesis for acetosellin biosynthesis.
journal_name
Planta Medjournal_title
Planta medicaauthors
Hufendiek P,Stölben SSM,Kehraus S,Merten N,Harms H,Crüsemann M,Arslan I,Gütschow M,Schneider T,König GMdoi
10.1055/s-0042-124493subject
Has Abstractpub_date
2017-08-01 00:00:00pages
1044-1052issue
12-13eissn
0032-0943issn
1439-0221journal_volume
83pub_type
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