Extracts from Pygeum africanum and other ethnobotanical species with antiandrogenic activity.

abstract：:In our ongoing efforts to identify effective naturally sourced agents for the treating of diabetic complications, two new (1 and 2) and 11 known phenolic compounds (3-13) were isolated from an 80 % ethanol extract of Litsea japonica leaves. The structures of the new compounds were established by spectroscopic and chem...

journal_title：Planta medica

authors： Lee IS,Kim YJ,Jung SH,Kim JH,Kim JS

更新日期：2017-02-01 00:00:00

abstract：:In natural product research, the isolation of biomarkers or bioactive compounds from complex natural extracts represents an essential step for de novo identification and bioactivity assessment. When pure natural products have to be obtained in milligram quantities, the chromatographic steps are generally labourious an...

journal_title：Planta medica

authors： Challal S,Queiroz EF,Debrus B,Kloeti W,Guillarme D,Gupta MP,Wolfender JL

更新日期：2015-11-01 00:00:00

abstract：:Micellar electrokinetic capillary chromatography (MECC), using a phosphate buffer pH 7.0 and sodium dodecyl sulfate as the surfactant, was found suitable for the separation of structurally similar flavan-3-ols and related dimeric proanthocyanidins. A total of 20 substances has been tested, 17 of which were successfull...

journal_title：Planta medica

authors： Kreimeyer J,Petereit F,Nahrstedt A

更新日期：1998-02-01 00:00:00

abstract：:From leaves of Penstemon barbatus Nutt. a new iridoid glucoside has been isolated. The structure was established mainly by spectroscopic methods ( (1)H-NMR, (13)C-NMR, IR, MS). ...

journal_title：Planta medica

authors： Junior P

更新日期：1982-06-01 00:00:00

abstract：:Anti-sera against a complement-activating pectin (AR-2IIb), which was purified from the roots of Angelica acutiloba Kitagawa, were obtained by immunization of rabbits, and a polyclonal anti-AR-2IIb antibody of the IgG class was purified by affinity chromatography on AR-2IIb-immobilized Sepharose and Protein G-Sepharos...

journal_title：Planta medica

authors： Wang NL,Kiyohara H,Matsumoto T,Otsuka H,Hirano M,Yamada H

更新日期：1994-10-01 00:00:00

abstract：:A phytochemical study of the roots of Pongamia pinnata afforded 29 flavanones and flavanols, including 7 previously undescribed compounds. The structures of the isolated compounds were determined by 1D and 2D NMR and mass spectroscopy data. The absolute configurations of the compounds were assigned via analysis of the...

journal_title：Planta medica

authors： Wen R,Lv H,Jiang Y,Tu P

更新日期：2018-11-01 00:00:00

abstract：:Electrospray ionization mass spectrometry (ESI-MS) combined with multiple tandem mass spectrometry (MS (n)) has been applied for simultaneously determining lipo-alkaloids from the aconite tubers. ESI-MS can give a very good mass separation for lipo-alkaloid mixture and MS (n) can provide structural information. Accord...

journal_title：Planta medica

authors： Sun W,Song F,Cui M,Liu S

更新日期：1999-06-01 00:00:00

abstract：:A fixed combination of Berberis aristata and Silybum marianum (Berberol) has been used by patients with dyslipidaemia. The aim of the present meta-analysis was to systematically evaluate the efficacy and safety of a fixed combination of B. aristata and S. marianum (Berberol) on serum lipid levels compared to placebo i...

journal_title：Planta medica

authors： Tóth B,Németh D,Soós A,Hegyi P,Pham-Dobor G,Varga O,Varga V,Kiss T,Sarlós P,Erőss B,Csupor D

更新日期：2020-01-01 00:00:00

abstract：:Eight iridoid glucosides have been isolated from Euphrasia rostkoviana by the combination of open column- and high performance liquid chromatography. The structure of a new compound, named eurostoside, and the identity of the others have been established by chemical transformations and spectral evidence of the compoun...

journal_title：Planta medica

authors： Salama O,Sticher O

更新日期：1983-02-01 00:00:00

abstract：:A lyophilised hydroalcoholic extract of Melissa officinalis L. (Lamiaceae) has been evaluated for behavioral effects in mice. According to the traditional use of M. officinalis, sedative properties have been confirmed for low doses by the decrease of behavioral parameters measured in a non-familiar environment test (s...

journal_title：Planta medica

authors： Soulimani R,Fleurentin J,Mortier F,Misslin R,Derrieu G,Pelt JM

更新日期：1991-04-01 00:00:00

abstract：:Different oil-samples of Melissa officinalis L. were analysed by capillary GC/MS, using fused silica columns and E.I.-Mass-spectrometry. Comparing the observed mass-spectra with those of a spectral collection, 70 compounds of the oil were identified. Geranial, neral, 6-methyl-5-hepten-2-one, citronellal, geranyl-aceta...

journal_title：Planta medica

authors： Tittel G,Wagner H,Bos R

更新日期：1982-10-01 00:00:00

abstract：:We previously reported that total coumarins, the major active components of Urtica dentata Hand, exhibited substantial protection against the development of autoimmune diabetes. Diabetic nephropathy is one of the most serious complications of diabetes and is closely correlated with end-stage renal disease. We used the...

journal_title：Planta medica

authors： Cao H,Ji Y,Li W,Liu Y,Fu R,Xiang M

更新日期：2015-10-01 00:00:00

abstract：:Three steroidal saponins, including astrogorgiosides A (1) and B (2) bearing acetamido-glucose moieties, and astrogorgioside C (3) with a 19-nor and bearing an aromatized B ring steroid aglycone, together with a known major saponin dimorphoside A (4), were obtained from the gorgonian Astrogorgia dumbea collected near ...

journal_title：Planta medica

authors： Lu YN,Cui P,Tian XQ,Lou LG,Fan CQ

更新日期：2016-06-01 00:00:00

abstract：:Herpes simplex virus infections persist throughout the lifetime of the host and affect more than 80 % of the humans worldwide. The intensive use of available therapeutic drugs has led to undesirable effects, such as drug-resistant strains, prompting the search for new antiherpetic agents. Although diverse bioactivitie...

journal_title：Planta medica

authors： Nocchi SR,Companhoni MV,de Mello JC,Dias Filho BP,Nakamura CV,Carollo CA,Silva DB,Ueda-Nakamura T

更新日期：2017-04-01 00:00:00

abstract：:In this study we examined the ability of the furofuran lignan yangambin to influence the local and systemic responses induced by antigen or PAF in actively sensitized or normal rats. Given intraperitoneally 1 h before stimulation, yangambin inhibited the pleural neutrophil and eosinophil infiltration evoked by the i.p...

journal_title：Planta medica

authors： Serra MF,Diaz BL,Barreto EO,Pereira AP,Lima MC,Barbosa-Filho JM,Cordeiro RS,Martins MA,de Silva PM

更新日期：1997-06-01 00:00:00

abstract：:The in vitro antiprotozoal activity of 18 natural flavonoids has been determined against Entamoeba histolytica and Giardia lamblia. (-)-Epicatechin, (-)-epigallocatechin and kaempferol were the most active flavonoids against both protozoa. ...

journal_title：Planta medica

authors： Calzada F,Meckes M,Cedillo-Rivera R

更新日期：1999-02-01 00:00:00

abstract：:Endocrine activity can be demonstrated for components of the rhizome of CIMICIFUGA RACEMOSA using ovariectomized rats as experimental model. A selective reduction of the serum concentration of the pituitary luteinizing hormone (LH) takes place upon application of an extract. The active principle can be concentrated by...

journal_title：Planta medica

authors： Jarry H,Harnischfeger G

更新日期：1985-02-01 00:00:00

abstract：:The oligomeric stilbenes (+)-alpha-viniferin (1), miyabenol C (2), and kobophenol A (3) have been isolated from Caragana sinica (Buchoz) Rehd (Leguminosae). (+)-alpha-Viniferin (1) and miyabenol C (2) exhibited protein kinase C inhibitory activity at low micromolar concentrations. (+)-alpha-Viniferin inhibited keratin...

journal_title：Planta medica

authors： Kulanthaivel P,Janzen WP,Ballas LM,Jiang JB,Hu CQ,Darges JW,Seldin JC,Cofield DJ,Adams LM

更新日期：1995-02-01 00:00:00

abstract：:Our investigations into the stability of tincture preparations of milk thistle fruit [ Silybum marianum L. Gaertn. (Asteraceae)] have led to the characterization of a new flavonolignan 4-(4-hydroxy-3-methoxyphenyl)-7-[(2 R,3 R)-3,5,7-trihydroxy-4-oxochroman-2-yl]-1-oxo-1,3,3a,4,5,7a-hexahydro-2-benzofuran-5-carboxylic...

journal_title：Planta medica

authors： MacKinnon SL,Hodder M,Craft C,Simmons-Boyce J

更新日期：2007-09-01 00:00:00

abstract：:Scientific achievements in the last two decades have revolutionized the treatment and prevention of breast cancer. This is mainly because of targeted therapies and a better understanding of the relationship between estrogen, its receptor, and breast cancer. One of these discoveries is the use of synthetic selective es...

journal_title：Planta medica

authors： Oseni T,Patel R,Pyle J,Jordan VC

更新日期：2008-10-01 00:00:00

abstract：:Olive oil has been shown to exhibit beneficial effects in the prevention of cardiovascular diseases although its molecular mechanism still remains unclear. In the present study, we investigated the effect of hydroxytyrosol (HT), a major phenolic component in olive oil and leaves from OLEA EUROPAEA L. (Oleaceae family...

journal_title：Planta medica

authors： Zrelli H,Matsuka M,Araki M,Zarrouk M,Miyazaki H

更新日期：2011-10-01 00:00:00

abstract：:Verbascoside is a phenylethanoid glycoside widely distributed in nature, especially among the order Lamiales, occurring in numerous plants that are constituents of folk medicine preparations. This natural compound, previously isolated by our group from the ethyl acetate extract of Lantana trifolia using the gradient a...

journal_title：Planta medica

authors： Leitão GG,Pinto SC,de Oliveira DR,Timoteo P,Guimarães MG,Cordova WH,Leitão SG

更新日期：2015-11-01 00:00:00

abstract：:A plant mixture containing extracts of Nigella sativa possesses blood glucose lowering effects, but the direct antidiabetic effect of Nigella sativa is not yet established. Therefore, the effect of Nigella sativa oil (NSO) on blood glucose concentrations was studied in streptozotocin diabetic rats. In addition, the ef...

journal_title：Planta medica

authors： El-Dakhakhny M,Mady N,Lembert N,Ammon HP

更新日期：2002-05-01 00:00:00

abstract：:From the rhizomes of HYPOXIS OBTUSA two monoglucosides having the same aglycone as hypoxoside, 1-(3',4'- dihydroxyphenyl)-5-(3'',4''-dihydroxyphenyl)-1-pen-ten-4-yne, have been obtained. By methylation followed by hydrogenation they have been transformed into the same compound, 1-(3'-methoxy-4'- O-beta- D-glucopyranos...

journal_title：Planta medica

authors： Galeffi C,Multari G,De Vicente Y,Messana I,Nicoletti M,Marini-Bettolo GB

更新日期：1989-06-01 00:00:00

abstract：:The antisecretory activity of Guazuma ulmifolia bark was examined in rabbit distal colon mounted in an Ussing chamber. Chloride secretion was stimulated by cholera toxin and prostaglandin E2 (PGE2). Guazuma ulmifolia extract (GUE) completely inhibited cholera toxin-induced secretion if the extract was added to the muc...

journal_title：Planta medica

authors： Hör M,Rimpler H,Heinrich M

更新日期：1995-06-01 00:00:00

abstract：:Propolis has been reported to display a broad spectrum of biological activities such as anticancer, antioxidant, anti-inflammatory, antibiotic and antifungal properties, among others. There is great interest not only in the determination of the chemical composition of propolis but also in the understanding of the mech...

journal_title：Planta medica

authors： Tavares DC,Lira WM,Santini CB,Takahashi CS,Bastos JK

更新日期：2007-12-01 00:00:00

abstract：:Five new compounds, including one new xanthone, 1-hydroxy-5-methoxyxanthone 6-O-β-D-glucopyranoside (1), one new lignan, 3-(β-D-glucopyranosyloxymethyl)-2-(4-hydroxy-3-methoxyphenyl)-5-(3-acetoxypropyl)-7-methoxy-(2R,3S)-dihydrobenzofuran (2), and three new γ-pyrones, japonicumone A 4'-O-β-D-glucopyranoside (3), japon...

journal_title：Planta medica

authors： Zhou GS,Ma XL,Zeng KW,Tu PF,Jiang Y

更新日期：2013-05-01 00:00:00

abstract：:Tuberculosis, also called TB, is currently a major health hazard due to multidrug-resistant forms of bacilli. Global efforts are underway to eradicate TB using new drugs with new modes of action, higher activity, and fewer side effects in combination with vaccines. For this reason, unexplored new sources and previousl...

journal_title：Planta medica

authors： Santhosh RS,Suriyanarayanan B

更新日期：2014-01-01 00:00:00

abstract：:Raspberry ketone (RK) is a natural phenolic compound of the red raspberry. The dietary administration of RK to male mice has been reported to prevent high-fat diet-induced elevation in body weight and to increase lipolysis in white adipocytes. To elucidate a possible mechanism for the antiobesity action of RK, its eff...

journal_title：Planta medica

authors： Park KS

更新日期：2010-10-01 00:00:00

abstract：:Alpinia galanga, or galangal, has been a popular condiment used in Thai and Asian cuisine for many years. However, relatively little is known of the potential beneficial or adverse health effects of this spice. This study was conducted to analyze the capacity of galangal extract to induce cytotoxicity and DNA damage i...

journal_title：Planta medica

authors： Muangnoi P,Lu M,Lee J,Thepouyporn A,Mirzayans R,Le XC,Weinfeld M,Changbumrung S

更新日期：2007-07-01 00:00:00