Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes.

Abstract:

:Raspberry ketone (RK) is a natural phenolic compound of the red raspberry. The dietary administration of RK to male mice has been reported to prevent high-fat diet-induced elevation in body weight and to increase lipolysis in white adipocytes. To elucidate a possible mechanism for the antiobesity action of RK, its effects on the expression and the secretion of adiponectin, lipolysis, and fatty acid oxidation in 3T3-L1 were investigated. Treatment with 10 µM of RK increased lipolysis significantly in differentiated 3T3-L1 cells. An immunoassay showed that RK increased both the expression and the secretion of adiponectin, an adipocytokine mainly expressed and secreted by adipose tissue. In addition, treatment with 10 µM of RK increased the fatty acid oxidation and suppressed lipid accumulation in 3T3-L1 adipocytes. These findings suggest that RK holds great promise as an herbal medicine since its biological activities alter the lipid metabolism in 3T3-L1 adipocytes.

journal_name

Planta Med

journal_title

Planta medica

authors

Park KS

doi

10.1055/s-0030-1249860

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

1654-8

issue

15

eissn

0032-0943

issn

1439-0221

journal_volume

76

pub_type

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