Silyamandin, a new flavonolignan isolated from milk thistle tinctures.

Abstract:

:Our investigations into the stability of tincture preparations of milk thistle fruit [ Silybum marianum L. Gaertn. (Asteraceae)] have led to the characterization of a new flavonolignan 4-(4-hydroxy-3-methoxyphenyl)-7-[(2 R,3 R)-3,5,7-trihydroxy-4-oxochroman-2-yl]-1-oxo-1,3,3a,4,5,7a-hexahydro-2-benzofuran-5-carboxylic acid called silyamandin (1). Incubation of the tincture at 40 degrees C for 3 months resulted in an increase in the level of this compound, as observed in the LC/DAD silymarin profile.

journal_name

Planta Med

journal_title

Planta medica

authors

MacKinnon SL,Hodder M,Craft C,Simmons-Boyce J

doi

10.1055/s-2007-981595

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

1214-6

issue

11

eissn

0032-0943

issn

1439-0221

journal_volume

73

pub_type

杂志文章
  • An approach to the antiinflammatory activity of borjatriol.

    abstract::The antiinflammatory activity of borjatriol (a diterpenoid isolated from SIDERITIS MUGRONENSIS Borja) was tested using the cotton pellet-granuloma assay. The compound inhibited the granuloma weight and the serum lysozyme activity in a dose-dependently way. The determination of this enzyme has allowed us to distinguish...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-969630

    authors: Villar A,Salom R,Alcaraz MJ

    更新日期:1984-02-01 00:00:00

  • Regulation of human pregnane X receptor and its target gene cytochrome P450 3A by praeruptorin A isolated from the herbal medicine Peucedanum praeruptorum.

    abstract::Qianhu, the dried roots of Peucedanum praeruptorum, is a well-known traditional Chinese medicinal herb which was officially listed in the Chinese Pharmacopoeia. Praeruptorin A is the major active constituent of Qianhu. Our previous studies show that praeruptorin effectively transactivated the protein expression and ca...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0033-1350795

    authors: Huang L,Bi HC,Li YH,Zhang JQ,Kuang SY,Zhang L,Wang YT,Huang M

    更新日期:2013-11-01 00:00:00

  • Citral is a new inducer of caspase-3 in tumor cell lines.

    abstract::Citral, 3,7-dimethyl-2,6-octadien-1-al, a key component of the lemon-scented essential oils extracted from several herbal plants such as lemon grass (Cymbopogon citratus), melissa (Melissa officinalis), verbena (Verbena officinalis) is used as a food additive and as a fragrance in cosmetics. In this study, we investig...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2005-864146

    authors: Dudai N,Weinstein Y,Krup M,Rabinski T,Ofir R

    更新日期:2005-05-01 00:00:00

  • Assessment of antimycobacterial activity of a series of mainly marine derived natural products.

    abstract::A series of mainly marine derived natural products were tested for their activities against Mycobacterium tuberculosis and M. avium. Of the thirty-nine compounds tested fifteen demonstrated minimum inhibition concentrations (MICs) of 32 micrograms/ml or less, and eleven had MICs of 16 micrograms/ml or less. The most a...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2000-8534

    authors: König GM,Wright AD,Franzblau SG

    更新日期:2000-05-01 00:00:00

  • Inhibition of human dendritic cell activation by hydroethanolic but not lipophilic extracts of turmeric (Curcuma longa).

    abstract::Turmeric has been extensively utilized in Indian and Chinese medicine for its immune-modulatory properties. Dendritic cells (DCs) are antigen-presenting cells specialized to initiate and regulate immunity. The ability of DCs to initiate immunity is linked to their activation status. The effects of turmeric on human DC...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0028-1088367

    authors: Krasovsky J,Chang DH,Deng G,Yeung S,Lee M,Leung PC,Cunningham-Rundles S,Cassileth B,Dhodapkar MV

    更新日期:2009-03-01 00:00:00

  • Anti-complementary activity of Crataegus sinaica.

    abstract::The 80% and 70% acetone extracts from fruits and leaves of Crataegus sinaica Boiss (Rosaceae) and the ethyl acetate-, butanol-, and water-fractions obtained from these initial extracts as well as the isolated compounds, quercetin (1) (1), hyperoside (quercetin 3-O-galactoside) (2) (2), rutin (quercetin 3-O-rutinoside)...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-957786

    authors: Shahat AA,Hammouda F,Ismail SI,Azzam SA,De Bruyne T,Lasure A,Van Poel B,Pieters L,Vlietinck AJ

    更新日期:1996-02-01 00:00:00

  • [Iridoid Glucosides from Euphrasia rostkoviana].

    abstract::Eight iridoid glucosides have been isolated from Euphrasia rostkoviana by the combination of open column- and high performance liquid chromatography. The structure of a new compound, named eurostoside, and the identity of the others have been established by chemical transformations and spectral evidence of the compoun...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-969960

    authors: Salama O,Sticher O

    更新日期:1983-02-01 00:00:00

  • The structure and the stereochemistry of atractyliretin.

    abstract::The nor-kaurane diterpene Atractyliretin was obtained by acid hydrolysis of Atractyloside, a toxic substance isolated from ATRACTYLIS GUMMIFERA L (Compositae). On the basis of spectral (IR, (1)H-NMR, (13)C-NMR and MS) analysis and chemical degradation its structure and stereochemistry was identified as 4. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-969185

    authors: Camarda L,Ceraulo L,Ferrugia M,Pascual C,Sprio V

    更新日期:1986-10-01 00:00:00

  • [Determination of structures by H NMR at 400 MHz: albifloranine, a new alkaloid from Tabernaemontana albiflora].

    abstract::The structure of albifloranine 1, a new alkaloid of ibogane type from the stem bark of Tabernaemontana albiflora (M IQ.) Pull. (Apocynaceae) has been determined. A detailed (1)H NMR study of albifloranine 1, coronaridine 2 and heyneanine 3 is presented. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-971678

    authors: Kan C,Husson HP,Kan SK,Lounasmaa M

    更新日期:1981-01-01 00:00:00

  • In vitro effect of valepotriates isolated from Valeriana glechomifolia on rat P-type ATPases.

    abstract::Valepotriates are iridoids found in variable amounts in Valerianaceae and might be among the bioactive compounds which confer anxiolytic properties to the Valeriana species. On the other hand, unspecific cytotoxicity has also been described. Presently, however, no particular molecular target has been defined for these...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0030-1271084

    authors: Bettero GM,Salles L,Rosário Figueira RM,Poser Gv,Rates SM,Noël F,Quintas LE

    更新日期:2011-10-01 00:00:00

  • Cytotoxic activity of Amaryllidaceae alkaloids.

    abstract::25 Amaryllidaceae alkaloids belonging to different skeletal types were evaluated for their cytotoxic activity against one murine non-tumoral cell line (LMTK) and two human tumoral cell lines (Molt4 and HepG2) according to established protocols. Significant differences of activity related with the type of skeleton of t...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2006-958007

    authors: Weniger B,Italiano L,Beck JP,Bastida J,Bergoñon S,Codina C,Lobstein A,Anton R

    更新日期:1995-02-01 00:00:00

  • Composition and antimicrobial activity of the essential oil of Peumus boldus leaves.

    abstract::The composition and the antimicrobial activity of the essential oil from the leaves of Peumus boldus is investigated. Analyses of the oil obtained by hydrodistillation were carried out by GC and GC-MS using columns of two different stationary phases. Fractionation of the essential oil by column chromatography on silic...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2006-960461

    authors: Vila R,Valenzuela L,Bello H,Cañigueral S,Montes M,Adzet T

    更新日期:1999-03-01 00:00:00

  • Composition and antimicrobial activity of the essential oil of Salvia ringens.

    abstract::The essential oils of Salvia ringens (samples A and B), were analyzed by means of GC and GC/MS. From the seventy-five identified constituents representing 99.82 and 99.86% of the oils, 1,8-cineole and alpha-pinene were the major components. Furthermore, sample B exhibited a very interesting antimicrobial profile after...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2001-10627

    authors: Tzakou O,Pitarokili D,Chinou IB,Harvala C

    更新日期:2001-02-01 00:00:00

  • Small-molecule STAT3 signaling pathway modulators from Polygonum cuspidatum.

    abstract::Constitutively activated STAT3 plays a pivotal role in oncogenesis and metastasis in many human cancers, and STAT3 has been validated as a novel anticancer drug target. Thus, the identification of small molecules that modulate STAT3 activity could be of great therapeutic importance. The aim of this study was to isolat...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0032-1315121

    authors: Liu J,Zhang Q,Chen K,Liu J,Kuang S,Chen W,Yu Q

    更新日期:2012-09-01 00:00:00

  • Essential Oil of Chrysanthemum indicum.

    abstract::The steam distilled oils both from flowers and leaves, as well as from total aerial parts of CHRYSANTHEMUM INDICUM L. (small-flowered form), were obtained and analyzed by GC and GC/MS. Their main components are borneol, chrysanthenone and bornyl acetate. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-969858

    authors: Stoianova-Ivanova B,Budzikiewicz H,Koumanova B,Tsoutsoulova A,Mladenova K,Brauner A

    更新日期:1983-12-01 00:00:00

  • A new epoxyflavanone from tephrosia hamiltonii1.

    abstract::A phytochemical study of the whole plant of TEPHROSIA HAMILTONII afforded a new flavonoid, characterised as 5, 7-dimethoxy-8-(2, 3-epoxy-3-methylbutyl)-flavanone, along with other known compounds. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-962679

    authors: Falak AH,Shoeb A

    更新日期:1987-04-01 00:00:00

  • Plasma pharmacokinetics and tissue distribution of arctiin and its main metabolite in rats by HPLC-UV and LC-MS.

    abstract::The pharmacokinetic profile of arctiin, the major active lignan in fruits of Arctium lappa L., was investigated. Its main meta"bolite arctigenin was identified by an LC-MS method, and an HPLC-UV technique was developed for the simultaneous quantification of the metabolite and arctiin in plasma and organs. Chromatograp...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0031-1298433

    authors: He F,Dou DQ,Sun Y,Zhu L,Xiao HB,Kang TG

    更新日期:2012-05-01 00:00:00

  • Isolation and Characterization of the Major Anthraquinone Pigments from Rumex abysinica.

    abstract::Emodin, chrysophanol and physcion have been shown to be the major anthraquinone pigments present in the dry roots of RUMEX ABYSINICA. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-969640

    authors: Munavu RM,Mudamba LO,Ogur JA

    更新日期:1984-02-01 00:00:00

  • In vitro formation of crocetin glucosyl esters by Crocus sativus callus extract.

    abstract::Callus extracts of Crocus sativus exhibited the ability to transform all-trans-crocetin into its related glycosides between pH 7.0 and 7.6 in the presence of uridine-diphospho-glucose. The reactions involved the step-wise addition of a glucose moiety to a free carboxyl function and the 1-->6 addition of a glucose moie...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-957633

    authors: Dufresne C,Cormier F,Dorion S

    更新日期:1997-04-01 00:00:00

  • The effect of the volatile oil from ginger rhizomes (Zingiber officinale), its fractions and isolated compounds on the 5-HT3 receptor complex and the serotoninergic system of the rat ileum.

    abstract::A contribution of the volatile oil from ginger rhizomes (Zingiber officinale Roscoe) on inhabiting the 5-HT3 receptor complex had been shown. In the present study a possible interaction of some compounds of the volatile oil with the 5-HT3 receptor system expressed in N1E-115 cells and with the serotoninergic system of...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-967171

    authors: Riyazi A,Hensel A,Bauer K,Geissler N,Schaaf S,Verspohl EJ

    更新日期:2007-04-01 00:00:00

  • Antiproliferative effects of abietane diterpenes from Aegiphila lhotzkyana.

    abstract::Five abietane diterpenes were isolated from a hexane extract obtained from the roots of Aegiphila lhotzkyana and identified as uncinatone, cyrtophyllone B, teunvicenone E, sugiol and 12,16-epoxy-11,14-dihydroxy-6-methoxy-17(15 - 16)- abeo-abieta-5,8, 11,13,15-pentaene-3,7-dione. The last compound has only been describ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2004-815499

    authors: Costa-Lotufo LV,Silveira ER,Barros MC,Lima MA,De Moraes ME,De Moraes MO,Pessoa C

    更新日期:2004-02-01 00:00:00

  • Labdane diterpenoids and shikimic acid derivatives from Araucaria cunninghamii.

    abstract::Four new (1-4) and two known compounds (5, 6) were isolated from the aerial parts of Araucaria cunninghamii. By analysis of UV, IR, MS, and NMR, the new compounds were identified as ENT-19-(Z)-coumaroyloxylabda-8(17),13(16),14-triene (1), ENT-19-( E)-coumaroyloxylabda-8(17),13(16),14-triene (2), shikimic acid N-butyl ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0030-1250570

    authors: Chen J,Chen JJ,Yang LQ,Hua L,Gao K

    更新日期:2011-03-01 00:00:00

  • Inhibition of the transcription factor NF-kappa B by sesquiterpene lactones from Podachaenium eminens.

    abstract::Investigation of Podachaenium eminens afforded nine sesquiterpene lactones (Sls) from which costunolide, 7-hydroxycostunolide, santamarin as well as 3-chlorodehydroleucodin are new for this plant and 3,4-dehydro-4-dehydroxypodachaenin (= 3-costoyloxydehydroleucodin) is found for the first time in nature. All isolated ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2000-8649

    authors: Castro V,Murillo R,Klaas CA,Meunier C,Mora G,Pahl HL,Merfort I

    更新日期:2000-10-01 00:00:00

  • Anti-Inflammatory Effects of Boldine and Reticuline Isolated from Litsea cubeba through JAK2/STAT3 and NF-κB Signaling Pathways.

    abstract::The anti-inflammatory effects of boldine and reticuline isolated from Litsea cubeba were evaluated by using xylene-induced ear edema and carrageenan-induced paw edema in mice and rats. Our results demonstrated that intragastric administration with boldine and reticuline significantly mitigated ear weight in mice and d...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0043-113447

    authors: Yang X,Gao X,Cao Y,Guo Q,Li S,Zhu Z,Zhao Y,Tu P,Chai X

    更新日期:2018-01-01 00:00:00

  • Two new saponins from the roots of Phytolacca esculenta.

    abstract::Two triterpenoidal saponins having phytolaccagenin as the aglycone were isolated from the roots of Phytolacca esculenta (Phytolaccaceae). The structures of two new saponins, esculentoside I and esculentoside N, were established to be 3-O-[beta-D-glucopyranosyl-(1----4)-beta-D- glucopyranosyl]-28-O-beta-D-glucopyranosy...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:

    authors: Yi YH

    更新日期:1992-02-01 00:00:00

  • Quantitative analysis of petasin and pyrrolizidine alkaloids in leaves and rhizomes of in situ grown Petasites hybridus plants.

    abstract::Various locations in Switzerland were screened for Petasites hybridus plants with high petasin and low pyrrolizidine alkaloid content. The mean petasin content of the various populations ranged from 7.4 to 15.3 mg/g dry weight in rhizomes and from 3.3 to 11.4 mg/g dry weight in leaves. Mean pyrrolizidine alkaloid cont...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-957422

    authors: Wildi E,Langer T,Schaffner W,Büter KB

    更新日期:1998-04-01 00:00:00

  • The Volatile Constituents of Ziziphora taurica subsp. cleonioides.

    abstract::The volatile constituents of ZIZIPHORA TAURICA subsp. CLEONIOIDES (Boiss.) P. H. Davis (Lamiaceae) were studied for the first time by analysis of the essential oil. 33 compounds, from the 44 consisting the total of the fraction, are identified by means of capillary GC and GC-MS. The identified components represent abo...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-962379

    authors: Kokkalou E

    更新日期:1988-04-01 00:00:00

  • Naturally occurring norephedrine oxazolidine derivatives in khat (Catha edulis).

    abstract::Khat (Catha edulis Forsk.) is a perennial shrub whose young leaves are chewed for their psychostimulating and anorectic properties. The main active principles of khat are believed to be the phenylpropylamino alkaloids, primarily (-)-cathinone [(S)-α-aminopropiophenone], (+)-cathine [(1S)(2S)-norpseudoephedrine], and (...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0031-1298430

    authors: Krizevski R,Bar E,Dudai N,Levy A,Lewinsohn E,Sitrit Y,Ben-Shabat S

    更新日期:2012-05-01 00:00:00

  • Extraction Method and Analysis of Cannabinoids in Cannabis Olive Oil Preparations.

    abstract::Recently, an increasing number of pharmacists had to supply medicinal products based on Cannabis sativa L. (Cannabaceae), prescribed by physicians to individual patients. Cannabis olive oil preparation is the first choice as a concentrated extract of cannabinoids, even though standardized operative conditions for obta...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0043-123074

    authors: Casiraghi A,Roda G,Casagni E,Cristina C,Musazzi UM,Franzè S,Rocco P,Giuliani C,Fico G,Minghetti P,Gambaro V

    更新日期:2018-03-01 00:00:00

  • Growth inhibition and G1 cell cycle arrest mediated by 25-methoxyhispidol A, a novel triterpenoid, isolated from the fruit of Poncirus trifoliata in human hepatocellular carcinoma cells.

    abstract::Poncirus trifoliata (Rutaceae) extracts have been known to possess anti-allergic, anti-inflammatory and antiviral activities. However, other biological activities, especially, the anticancer potential of extracts of P. trifoliata or its constituents, have not been fully investigated yet. In this study, we have evaluat...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034286

    authors: Hong J,Min HY,Xu GH,Lee JG,Lee SH,Kim YS,Kang SS,Lee SK

    更新日期:2008-02-01 00:00:00