Citral is a new inducer of caspase-3 in tumor cell lines.


:Citral, 3,7-dimethyl-2,6-octadien-1-al, a key component of the lemon-scented essential oils extracted from several herbal plants such as lemon grass (Cymbopogon citratus), melissa (Melissa officinalis), verbena (Verbena officinalis) is used as a food additive and as a fragrance in cosmetics. In this study, we investigated the anti-cancer potential of citral and its mode of action. Concentrations of 44.5 muM, comparable to the concentration of citral in a cup of tea prepared from 1 g of lemon grass, induced apoptosis in several hematopoietic cancer cell lines. Apoptosis was accompanied by DNA fragmentation and caspase-3 catalytic activity induction. Citral activity (22.25 microM) was compared to a reference compound like staurosporine (0.7 microM), in respect to DNA fragmentation and caspase-3 enzymatic activity. The apoptotic effect of citral depended on the alpha,beta-unsaturated aldehyde group.


Planta Med


Planta medica


Dudai N,Weinstein Y,Krup M,Rabinski T,Ofir R




Has Abstract


2005-05-01 00:00:00












  • New Phenolic Derivatives from Galeola faberi.

    abstract::Seven phenolic derivatives, 2,4-bis(4-hydroxybenzyl)phenol ( 1), bis[4(beta- D-glucopyranosyloxy)-benzyl] ( S)-(-)-2-isopropylmalate ( 2), bis[4-(beta- D-gluco-pyranosyloxy)benzyl] ( S)-(-)-2-sec-butylmalate ( 3), 4-hydroxybenzyaldehyde ( 4), 4,4'-dihydroxydiphenyl-methane ( 5), 4-hydroxybenzyl alcohol ( 6), and 4-(be...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Yi-Ming L,Zhuo-Lun Z,Yong-Fu H

    更新日期:1993-08-01 00:00:00

  • Erythrinaline alkaloids and antimicrobial flavonoids from Erythrina latissima.

    abstract::The seed pods of Erythrina latissima yielded erysotrine, erysodine, syringaresinol, vanillic acid, a new erythrina alkaloid, (+)-10,11-dioxoerysotrine, which was lethal to brine shrimp and 2-(5'-hydroxy-3'-methoxy phenyl)-6-hydroxy-5-methoxybenzofuran, which showed strong antimicrobial activity against the yeast spore...

    journal_title:Planta medica

    pub_type: 信件


    authors: Wanjala CC,Juma BF,Bojase G,Gashe BA,Majinda RR

    更新日期:2002-07-01 00:00:00

  • Leaf Decoction of Carica papaya Combined with Artesunate Prevents Recrudescence in Plasmodium berghei-Infected Mice.

    abstract::Malaria treatment and control have become increasingly difficult because of the spread of drug-resistant strains of Plasmodium falciparum and Plasmodium vivax. Thus, there is a continuous need to develop new combination therapies such as artemisinin-based combination therapies (ACTs) to contrast the emergence of resis...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Sannella AR,Karioti A,Orsini S,Scalone A,Gradoni L,Messori L,Severini C,Bilia AR

    更新日期:2019-08-01 00:00:00

  • Alterations in sulfur amino acid metabolism in mice treated with silymarin: a novel mechanism of its action involved in enhancement of the antioxidant defense in liver.

    abstract::It has been known that silymarin exhibits protective activity against oxidative liver injury induced by various hepatotoxicants, but the underlying mechanism of its beneficial action remains unclear. We determined the alterations in sulfur-containing amino acid metabolism induced by silymarin in association with its e...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Kwon DY,Jung YS,Kim SJ,Kim YS,Choi DW,Kim YC

    更新日期:2013-08-01 00:00:00

  • Inhibition of platelet aggregation by shikonin derivatives isolated from Arnebia euchroma.

    abstract::Four antiplatelet components were isolated from Arnebia euchroma. They inhibited the aggregation of washed rabbit platelets caused by collagen, arachidonic acid, platelet-activating factor, ADP, or thrombin. The potency of inhibiting collagen-induced platelet aggregation is in the following order: acetylshikonin (IC50...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Chang YS,Kuo SC,Weng SH,Jan SC,Ko FN,Teng CM

    更新日期:1993-10-01 00:00:00

  • Berberine inhibits cell growth and mediates caspase-independent cell death in human pancreatic cancer cells.

    abstract::Pancreatic cancer is one of the most aggressive human malignancies with an increasing incidence worldwide. In addition to the poor survival rates, combinations using gemcitabine as a backbone have failed to show any benefit beyond monotherapy. These facts underscore an urgent need for novel therapeutic options and mot...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Pinto-Garcia L,Efferth T,Torres A,Hoheisel JD,Youns M

    更新日期:2010-08-01 00:00:00

  • Effect of abietane diterpenes from Plectranthus grandidentatus on the growth of human cancer cell lines.

    abstract::Five known abietane diterpenes, fatty acid esters of 7alpha-acyloxy-6beta-hydroxyroyleanone (1), grandidone A (2), 7alpha-acetoxy-6beta-hydroxyroyleanone (3), 6beta,7alpha-dihydroxyroyleanone (4), and coleon U (5), isolated from Plectranthus grandidentatus Gürke, were evaluated for their in vitro antiproliferative act...

    journal_title:Planta medica

    pub_type: 信件


    authors: Marques CG,Pedro M,Simões MF,Nascimento MS,Pinto MM,Rodríguez B

    更新日期:2002-09-01 00:00:00

  • Molecular authentication of the traditional dai medicinal plant Croton caudatus.

    abstract::Croton caudatus is an important species in Dai folk medicine. Some other Croton species, in particular, C. kongensis, C. cascarilloides, C. crassifolius, C. lachnocarpus and C. olivaceus are often marketed as C. caudatus, and thus, the therapeutic effects of C. caudatus are not achieved. The respective morphological f...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Xue HG,Zhou SD,He XJ,Yu Y

    更新日期:2007-06-01 00:00:00

  • Microbiological status of commercially available medicinal herbal drugs--a screening study.

    abstract::One hundred and thirty-eight medicinal herbal drugs obtained from different suppliers were examined for microbial contaminants and for the detectability of pathogenic microorganisms. For this purpose, several microbiological standard parameters (total aerobic mesophilic count, enterobacteria, coliforms, aerobic sporef...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Czech E,Kneifel W,Kopp B

    更新日期:2001-04-01 00:00:00

  • Dodonic Acid, A New Diterpenoid from Dodonaea viscosa1.

    abstract::The aerial parts of DODONAEA VISCOSA afforded a new diterpenoid, dodonic acid, the structure and stereochemistry of which have been established by chemical and spectroscopic means. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Sachdev K,Kulshreshtha DK

    更新日期:1984-10-01 00:00:00

  • The selective antianginal effect without changing blood pressure of butylidenephthalide in conscious rats.

    abstract::Synthetic butylidenephthalide (Bdph), 60 mg/kg per os (p.o.) given 3 h prior to injection of pituitrin (4 U/kg, i.v.), significantly prevented T-wave lowering on lead II electrocardiograph in unanesthetized rats. The effective dose, 60 mg/kg, was about 1/56th of the median lethal dose (LD50, p.o.) in rats. However, Bd...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Ko WC,Sheu JR,Tzeng SH,Chen CM

    更新日期:1998-04-01 00:00:00

  • Aromatase inhibitory activities of standishinal and the diterpenoids from the bark of Thuja standishii.

    abstract::The absolute stereostructure of a novel skeletal diterpene, standishinal (1), from the bark of Thuja standishii was confirmed by X-ray crystallographic analyses of 1 and its p-bromobenzoate derivative. Aromatase inhibitory activities of standishinal, eight known diterpenes, totarol, 12-methoxyabieta-8,11,13-trien-11-o...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Minami T,Iwamoto M,Ohtsu H,Ohishi H,Tanaka R,Yoshitake A

    更新日期:2002-08-01 00:00:00

  • Protective Effects of the Total Coumarin Fraction of Urtica dentata on Experimental Diabetic Nephropathy In Vitro and In Vivo.

    abstract::We previously reported that total coumarins, the major active components of Urtica dentata Hand, exhibited substantial protection against the development of autoimmune diabetes. Diabetic nephropathy is one of the most serious complications of diabetes and is closely correlated with end-stage renal disease. We used the...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Cao H,Ji Y,Li W,Liu Y,Fu R,Xiang M

    更新日期:2015-10-01 00:00:00

  • Phenolic Compounds as Arginase Inhibitors: New Insights Regarding Endothelial Dysfunction Treatment.

    abstract::Endothelial dysfunction is characterised by the low bioavailability of nitric oxide with a relevant negative impact on the nitric oxide/cGMP pathway. The loss of nitric oxide/cGMP signaling may be caused by an increased arginase activity. Plant-derived substances, especially polyphenols, are compounds that have the po...

    journal_title:Planta medica

    pub_type: 杂志文章,评审


    authors: Minozzo BR,Fernandes D,Beltrame FL

    更新日期:2018-03-01 00:00:00

  • Natural Polyketides Isolated from the Endophytic Fungus Phomopsis sp. CAM212 with a Semisynthetic Derivative Downregulating the ERK/IκBα Signaling Pathways.

    abstract::Three previously undescribed natural products, phomopsinin A - C (1:  - 3: ), together with three known compounds, namely, cis-hydroxymellein (4: ), phomoxanthone A (5: ) and cytochalasin L-696,474 (6: ), were isolated from the solid culture of Phomopsis sp. CAM212, an endophytic fungus obtained from Garcinia xanthoch...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Jouda JB,Njoya EM,Fobofou SAT,Zhou ZY,Qiang Z,Mbazoa CD,Brandt W,Zhang GL,Wandji J,Wang F

    更新日期:2020-09-01 00:00:00

  • Assay of volatile oil-cyclodextrin complexes by pyrolyzis gas-chromatography.

    abstract::A pyrolytic gaschromatographic process was developed for the routine assay of both cyclodextrin inclusion complexes, and for the differentiation of the mechanical mixture of the same oil with beta-cyclodextrin. The method is a direct assay of low material demand. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Pobozsny K,Kernóczi L,Tétényi P,Héthelyi I,Szejtli J

    更新日期:1981-07-01 00:00:00

  • Anti-amoebic Activity of Leaf Extracts and Aporphine Alkaloids Obtained from Annona purpurea.

    abstract::Annona purpurea has been traditionally used by indigenous and socioeconomically disadvantaged people to treat infectious and parasitic diseases, including amoebiasis. The goal of this study was to assess the effect of a crude methanolic extract, an alkaloid extract, and aporphine alkaloids from leaves of A. purpurea o...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Díaz-Godínez C,Ontiveros-Rodríguez JC,Ríos-Valencia DG,Herbert-Pucheta JE,Zepeda-Vallejo LG,Carrero JC

    更新日期:2020-04-01 00:00:00

  • Inhibition of rat adjuvant-induced arthritis by ginkgetin, a biflavone from ginkgo biloba leaves.

    abstract::Ginkgetin, a biflavone isolated from Ginkgo biloba leaves, was previously reported as an inhibitor of group II phospholipase A2. In this study, ginkgetin was evaluated for in vivo antiarthritic and analgesic activities. Ginkgetin (10-20 mg/kg/day) strongly reduced arthritic inflammation in an animal model of rat adjuv...

    journal_title:Planta medica

    pub_type: 信件


    authors: Kim HK,Son KH,Chang HW,Kang SS,Kim HP

    更新日期:1999-06-01 00:00:00

  • Anthelmintic activity of the natural compound (+)-limonene epoxide against Schistosoma mansoni.

    abstract::Blood fluke of the genus Schistosoma are the etiological agents of human schistosomiasis, an important neglected tropical disease that afflicts over 200 million people worldwide. The treatment for this disease relies heavily on a single drug, praziquantel. Recent reports of praziquantel resistance raise concerns about...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Moraes Jd,Almeida AA,Brito MR,Marques TH,Lima TC,Sousa DP,Nakano E,Mendonça RZ,Freitas RM

    更新日期:2013-03-01 00:00:00

  • Minor Alkaloids of Corydalis bulbosa, Structure of Bulbodione.

    abstract::As a result of the reinvestigation of the alkaloid content of CORYDALIS BULBOSA (L.) DC. (Papaveraceae), growing in Bulgaria, a new 8,11-dioxoaporphine alkaloid, named bulbodione, together with dihydrosanguinarine, dehydroglaucine, (+/-)-sinactine, glaucinone and bicucullinine were isolated. These six alkaloids had no...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Kiryakov HG,Iskrenova ES

    更新日期:1984-04-01 00:00:00

  • Immobilization of strictosidine synthase from Catharanthus cell cultures and preparative synthesis of strictosidine.

    abstract::Strictosidine synthase was partially purified from Catharanthus roseus cell suspension cultures and immobilized on CNBr-activated Sepharose. The immobilized enzyme exhibits a thermostability increased 300 fold over that of the soluble enzyme and catalyses exclusively the formation of the 3alpha(S)-isomer, strictosidin...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Pfitzner U,Zenk MH

    更新日期:1982-09-01 00:00:00

  • Four new benzofurans from seeds of Styrax perkinsiae.

    abstract::Four new benzofurans trans-5-(3-hydroxypropyl)-7-methoxy-2-[2,3-dihydro-3-hydroxymethyl-7-methoxy-2-(3-methoxy-4-hydroxyphenyl)-benzofuran-5-yl]benzofuran (1), (E)-5-(2-formylvinyl)-7-methoxy-2-(3,4-methylenedioxyphenyl)benzofuran (2), 5-(3-butanoyloxypropyl)-7-methoxy-2-(3,4-methylenedioxyphenyl)benzofuran (3), and 5...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Li QL,Li BG,Qi HY,Gao XP,Zhang GL

    更新日期:2005-09-01 00:00:00

  • Stimulatory effect of paeoniflorin on adenosine release to increase the glucose uptake into white adipocytes of Wistar rat.

    abstract::The present study investigated the role of adenosine in the stimulatory action of paeoniflorin on in vitro glucose transport. Paeoniflorin increased the uptake of a radiolabeled, non-metabolizable glucose derivative into isolated white adipocytes of Wistar rat in a concentration-dependent manner and this action was ab...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Tang LM,Liu IM,Cheng JT

    更新日期:2003-04-01 00:00:00

  • Protective Effects of α-Boswellic Acids in a Pulmonary Arterial Hypertensive Rat Model.

    abstract::The purpose of this study was to observe the protective effects of α-boswellic acids on hypoxia-induced pulmonary vascular structural remodeling in pulmonary arterial smooth muscle cells in a hypertensive rat model. Pulmonary arterial smooth muscle cells were cultured and then randomly divided into four groups: normox...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Xiao B,Zhang G,Ali Sheikh MS,Shi R

    更新日期:2017-01-01 00:00:00

  • Effects of propolis crude hydroalcoholic extract on chromosomal aberrations induced by doxorubicin in rats.

    abstract::Propolis has been reported to display a broad spectrum of biological activities such as anticancer, antioxidant, anti-inflammatory, antibiotic and antifungal properties, among others. There is great interest not only in the determination of the chemical composition of propolis but also in the understanding of the mech...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Tavares DC,Lira WM,Santini CB,Takahashi CS,Bastos JK

    更新日期:2007-12-01 00:00:00

  • Re-introduction of kava (Piper methysticum) to the EU: is there a way forward?

    abstract::Kava (Piper methysticum) is an effective anxiolytic that has been withdrawn from various consumer markets in European countries due to concerns over its hepatotoxicity. It is plausible that the reported hepatotoxicity may be due in part to plant substitution, or an incorrect cultivar, or plant parts being used (such a...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Sarris J,Teschke R,Stough C,Scholey A,Schweitzer I

    更新日期:2011-01-01 00:00:00

  • Composition of the Essential Oil of Cymbopogon travancorensis.

    abstract::The chemical composition of the essential oil of CYMBOPOGON TRAVANCORENSIS Bor. (Poaceae) was investigated by capillary GC and GC-MS. Thirty-five compounds were identified. The oil contains mono- and sesquiterpene hydrocarbons (39.60%), oxygenated terpenes (30.45%), and phenyl propanoids (22.04%). The main constituent...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Mallavarapu GR,Ramesh S,Kulkarni RN,Syamasundar KV

    更新日期:1992-04-01 00:00:00

  • Guaianolides from Lactuca saligna.

    abstract::The phytochemical investigation of the aerial parts of LACTUCA SALIGNA L. revealed the presence of lactucin, lactucopicrin, and a new guaianolide named 11beta,13-dihydrolactucopicrin. The structural configuration was established through spectral data. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Khalil AT,El-Fattah HA,Mansour ES

    更新日期:1991-04-01 00:00:00

  • In vitro antimalarial activity of Coutarea latiflora and Exostema caribaeum extracts on Plasmodium falciparum.

    abstract::The medicinal plants, Coutarea latiflora Sesse & Moc. ex. DC. (Hintonia latiflora Bullock) (Rubiaceae) and Exostema caribaeum (Jacq.) Roem. et Schult. (Rubiaceae) were examined for antimalarial properties. Among different crude solvent extracts of the stem bark, the hydrolysed ethyl acetate extracts were shown to have...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Noster S,Kraus L

    更新日期:1990-02-01 00:00:00

  • Enhanced hypotensive effects of the essential oil of Ocimum gratissimum leaves and its main constituent, eugenol, in DOCA-salt hypertensive conscious rats.

    abstract::The cardiovascular effects of intravenous (i.v.) treatment with the essential oil of Ocimum gratissimum (EOOG) and its main constituent, eugenol (Eug) were investigated in the experimental model of deoxycorticosterone acetate (DOCA-salt)-hypertensive rats. In both conscious DOCA-salt hypertensive rats and their uninep...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Interaminense LF,Leal-Cardoso JH,Magalhães PJ,Duarte GP,Lahlou S

    更新日期:2005-04-01 00:00:00