Natural Phenolic Compounds and Derivatives as Potential Antimalarial Agents.

abstract：:A new steroidal saponin, timosaponin F, along with six known compounds was isolated from the rhizomes of Anemarrhena asphodeloides Bge. On the basis of chemical and spectroscopic evidence, the structure of timosaponin F was elucidated as (5beta, 25 S):-spirostan-3beta,15alpha,23alpha-triol-3-O-beta- glucopyranosyl-(1-...

journal_title：Planta medica

authors： Meng ZY,Zhang JY,Xu SX,Sugahara K

更新日期：1999-10-01 00:00:00

abstract：:DNA barcoding methods originally developed for the identification of plant specimens have been applied to the authentication of herbal drug materials for industrial quality assurance. These methods are intended to be complementary to current morphological and chemical methods of identification. The adoption of these m...

journal_title：Planta medica

authors： Sgamma T,Lockie-Williams C,Kreuzer M,Williams S,Scheyhing U,Koch E,Slater A,Howard C

更新日期：2017-10-01 00:00:00

abstract：:Ligusticum canbyi (J.M. Coult & Rose) is a medicinal understory forest species used in traditional rituals and ceremonies for spiritual enlightenment and improved mental health. Very little is known about the phytochemical complexity or diversity of L. canbyi tissues or extracts. The current study was undertaken to de...

journal_title：Planta medica

authors： Turi CE,Murch SJ

更新日期：2013-09-01 00:00:00

abstract：:During the screening of antimalarial substances, the 80% EtOH extract from the outer bark of Ochna integerrima Merr. (Ochnaceae) was shown to have a good anti-malarial activity (IC50 value: 6.5 microg/mL) whereas extracts from the inner barks of O.integerrima showed no antimalarial activity. Biflavanone (1), which had...

journal_title：Planta medica

authors： Ichino C,Kiyohara H,Soonthornchareonnon N,Chuakul W,Ishiyama A,Sekiguchi H,Namatame M,Otoguro K,Omura S,Yamada H

更新日期：2006-06-01 00:00:00

abstract：:Targeted isolation based on a combination of NMR and HPLC-PDA-MS of a dichloromethane extract of Thymus vulgaris Varico 3 aerial parts afforded one new p-cymene dimer, 6,3',4'-trihydroxy-5,5'-diisopropyl-2,2'-dimethylbiphenyl (1: ), together with two known p-cymene derivatives (2: and 3: ), as well as five known compo...

journal_title：Planta medica

authors： Stefanis I,Hadjipavlou-Litina D,Bilia AR,Karioti A

更新日期：2019-08-01 00:00:00

abstract：:In the present study, we demonstrate that saucernetin-8 ( 1) and saucernetin-7 ( 2), isolated from the underground parts of Saururus chinensis (Saururaceae), exerted potent inhibitory effects on LPS-induced nitric oxide (NO) and prostaglandin E (2) (PGE (2)) production in RAW 264.7 cells. Both compounds 1 and 2, known...

journal_title：Planta medica

authors： Park HJ,Kim RG,Seo BR,Ha J,Ahn BT,Bok SH,Lee YS,Kim HJ,Lee KT

更新日期：2003-10-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) infection can result in oxidative stress through production of reactive oxygen species (ROS). Simultaneously, oxidative stress is able to activate the replication of virus and lead to the apoptosis of T lymphocytes which is the defense of the immune function. Ampelopsin, belonging to...

journal_title：Planta medica

authors： Ye J,Guan Y,Zeng S,Liu D

更新日期：2008-02-01 00:00:00

abstract：:Two new lignans, (-)-aptosimon ( 1) and (-)-diasesamin-di-gamma-lactone ( 2), together with twenty-two known compounds, have been isolated from the stems and roots of Wikstroemia lanceolata. The structures of the new compounds were determined through spectral analyses. The proton and carbon assignments of the known se...

journal_title：Planta medica

authors： Lin RW,Tsai IL,Duh CY,Lee KH,Chen IS

更新日期：2004-03-01 00:00:00

abstract：:From the leaves of BLUMEA ARFAKIANA Martelli (Asteraceae), used in traditional medicine in Papua New Guinea, besides stigmasterol and beta-eudesmol, four graniline esters ( 1-4) have been isolated. Furthermore, blumealactone C ( 5), deacetylblumealactone C ( 6), and deoxyblumealactone C ( 7) have been identified. ...

journal_title：Planta medica

authors： Rücker G,Paulini G,Sakulas H,Lawong B,Goeltenboth F

更新日期：1991-06-01 00:00:00

abstract：:It has been known that silymarin exhibits protective activity against oxidative liver injury induced by various hepatotoxicants, but the underlying mechanism of its beneficial action remains unclear. We determined the alterations in sulfur-containing amino acid metabolism induced by silymarin in association with its e...

journal_title：Planta medica

authors： Kwon DY,Jung YS,Kim SJ,Kim YS,Choi DW,Kim YC

更新日期：2013-08-01 00:00:00

abstract：:YANG XIN is a traditional Chinese medicine formulation used for nervous fatigue and consists of a proprietary blend of concentrated extracts from 18 plant ingredients. The 18 constituent plant ingredients, YANG XIN capsules, and formulations 2014-005_1 A and 1B were extracted by consecutive 24-hour macerations with di...

journal_title：Planta medica

authors： Almalki AJ,Zaher A,Simithy J,Keller WJ,Tripp M,Calderón AI

更新日期：2016-08-01 00:00:00

abstract：:The effect of extracts of MOMORDICA CHARANTIA L. fruits on glucose metabolism and glucose uptake was investigated. The fruit of momordica, at all ripening stages, was found to contain two inhibitory compounds: one against hexokinase activity and the other against glucose uptake by rat intestinal fragments. Both inhibi...

journal_title：Planta medica

authors： Meir P,Yaniv Z

更新日期：1985-02-01 00:00:00

abstract：:Helanalin, a sesquiterpene lactone antineoplastic agent, is toxic at therapeutic doses in murine tumors. The toxicity has been assumed to be correlated with the binding of the drug to cellular thiol groups. Studies were undertaken to increase the intracellular level of GSH in the liver, kidney and other tissues to eli...

journal_title：Planta medica

authors： Hall IH,Grippo AA,Holbrook DJ,Roberts G,Lin HC,Kim HL,Lee KH

更新日期：1989-12-01 00:00:00

abstract：:From the bark of Sclerocarya birrea was isolated (-)-epicatechin-3-galloyl ester of which the structure was elucidated by NMR spectroscopy. The compound has secretagogue activity. ...

journal_title：Planta medica

authors： Galvez Peralta J,Zarzuelo A,Busson R,Cobbaert C,de Witte P

更新日期：1992-04-01 00:00:00

abstract：:Alpinia galanga, or galangal, has been a popular condiment used in Thai and Asian cuisine for many years. However, relatively little is known of the potential beneficial or adverse health effects of this spice. This study was conducted to analyze the capacity of galangal extract to induce cytotoxicity and DNA damage i...

journal_title：Planta medica

authors： Muangnoi P,Lu M,Lee J,Thepouyporn A,Mirzayans R,Le XC,Weinfeld M,Changbumrung S

更新日期：2007-07-01 00:00:00

abstract：:Quality control of drugs consists of identifying the raw material to avoid unwanted admixtures or exchange of material as well as looking for abiotic and biotic contaminations. So far, identity and microbial contamination are analyzed by separate processes and separate methods. Species identification by their DNA ("DN...

journal_title：Planta medica

authors： Schmiderer C,Lukas B,Ruzicka J,Novak J

更新日期：2018-04-01 00:00:00

abstract：:The anti-inflammatory effects of boldine and reticuline isolated from Litsea cubeba were evaluated by using xylene-induced ear edema and carrageenan-induced paw edema in mice and rats. Our results demonstrated that intragastric administration with boldine and reticuline significantly mitigated ear weight in mice and d...

journal_title：Planta medica

authors： Yang X,Gao X,Cao Y,Guo Q,Li S,Zhu Z,Zhao Y,Tu P,Chai X

更新日期：2018-01-01 00:00:00

abstract：:From the rhizomes of HYPOXIS OBTUSA two monoglucosides having the same aglycone as hypoxoside, 1-(3',4'- dihydroxyphenyl)-5-(3'',4''-dihydroxyphenyl)-1-pen-ten-4-yne, have been obtained. By methylation followed by hydrogenation they have been transformed into the same compound, 1-(3'-methoxy-4'- O-beta- D-glucopyranos...

journal_title：Planta medica

authors： Galeffi C,Multari G,De Vicente Y,Messana I,Nicoletti M,Marini-Bettolo GB

更新日期：1989-06-01 00:00:00

abstract：:A plant mixture containing extracts of Nigella sativa possesses blood glucose lowering effects, but the direct antidiabetic effect of Nigella sativa is not yet established. Therefore, the effect of Nigella sativa oil (NSO) on blood glucose concentrations was studied in streptozotocin diabetic rats. In addition, the ef...

journal_title：Planta medica

authors： El-Dakhakhny M,Mady N,Lembert N,Ammon HP

更新日期：2002-05-01 00:00:00

abstract：:Two new phenolic glycosides characterized as idesin salicylate (1) and 2-hydroxyphenol-1-O-beta-D-glucopyranosyl-(6-->1)- alpha-L-rhamnopyranoside (2) were isolated with four known compounds, idescarpin (3), idesin (4), 1-hydroxy-6-oxocyclohex-2-enecarboxylic acid methyl ester (5) and salirepin (6), from the fruits of...

journal_title：Planta medica

authors： Kim SH,Jang YP,Sung SH,Kim YC

更新日期：2007-02-01 00:00:00

abstract：:Shoot-tips from several genotypes of the cardenolide-producing perennial shrub Digitalis obscura L. were successfully cryopreserved using the encapsulation-dehydration technique. Precultivation on MS medium containing 0.5 M sucrose, followed by 2.5 h dehydration (final weight 30 %) induced shoot regrowth in 42 % of cr...

journal_title：Planta medica

authors： Sales E,Nebauer SG,Arrillaga I,Segura J

更新日期：2001-12-01 00:00:00

abstract：:The analysis of the volatile compounds in the essential oil of SOLIDAGO CANADENSISL. sensu lato (Compositae) GC and GC-MS demonstrated the presence of at least 36 compounds, 18 of which were identified. The Major comonenets are gamma (2)- and delta-cadinenes. ...

journal_title：Planta medica

authors： Kalemba D,Góra J,Kurowska A

更新日期：1990-04-01 00:00:00

abstract：:Turmeric has been extensively utilized in Indian and Chinese medicine for its immune-modulatory properties. Dendritic cells (DCs) are antigen-presenting cells specialized to initiate and regulate immunity. The ability of DCs to initiate immunity is linked to their activation status. The effects of turmeric on human DC...

journal_title：Planta medica

authors： Krasovsky J,Chang DH,Deng G,Yeung S,Lee M,Leung PC,Cunningham-Rundles S,Cassileth B,Dhodapkar MV

更新日期：2009-03-01 00:00:00

abstract：:Healing of predominantly metaphyseal fractures in postmenopausal osteoporosis is delayed and comparatively poor. Hormone replacement therapy could improve fracture healing, but, because of its potential side effects, natural alternatives are more appealing. The aim of this study was to determine if the soy metabolite ...

journal_title：Planta medica

authors： Kolios L,Sehmisch S,Daub F,Rack T,Tezval M,Stuermer KM,Stuermer EK

更新日期：2009-04-01 00:00:00

abstract：:In garlic (Allium sativum L.) the enzyme alliin lyase catalyzes the cleavage of alliin into allicin which reacts further to furnish ajoene. A simultaneous determination of allicin and ajoene is introduced which, in contrast to the determination of alliin only, allows for the testing of the activity of alliin lyase. It...

journal_title：Planta medica

authors： Blania G,Spangenberg B

更新日期：1991-08-01 00:00:00

abstract：:Positive inotropic effects induced by 6-benzylaminopurine (6-BAP), kinetin and zeatin were studied in rat atria. The potency order observed was 6-BAP > or = kinetin > zeatin. Suramin, a P2-purinoceptor antagonist, inhibited the positive effect of 6-BAP suggesting the involvement of P2-purinoceptors in the positive eff...

journal_title：Planta medica

authors： Froldi G,Gallo U,Ragazzi E,Caparrotta L

更新日期：1999-04-01 00:00:00

abstract：:Aerial parts of Persicaria lapathifolia S.F. Gray (Polygonaceae) exhibited an inhibitory effect on superoxide production in unopsonized zymosan-stimulated human monocytes. Two known compounds, quercetin 3-O-beta-(2"-galloyl)-glucopyranoside and quercetin 3-O-beta-(2"-galloyl)-rhamnopyranoside, and a new compound, quer...

journal_title：Planta medica

authors： Kim Y,Jang DS,Park SH,Yun J,Min BK,Min KR,Lee HK

更新日期：2000-02-01 00:00:00

abstract：:Bioactivity-guided fractionation of Saururus chinensis (Saururaceae) using a lymphoproliferation assay led us to isolate 5 lignans (compounds 1 - 5). Compounds 1 - 5 were identified as sauchinone, (-)-saucerneol, saucerneol C, manassantin A, and manassantin B, respectively, by spectroscopic analyses. The immunosuppres...

journal_title：Planta medica

authors： Park SY,Lee SH,Choi WH,Koh EM,Seo JH,Ryu SY,Kim YS,Kwon DY,Koh WS

更新日期：2007-06-01 00:00:00

abstract：:We have previously shown that 11 ent-kauranes isolated from the stems of Annona squamosa exhibited immunomodulating effects in leukocytes. In this study, a cellular model using isolated human neutrophils, which are important in the pathogenesis of rheumatoid arthritis, ischemia-reperfusion injury, chronic obstructive ...

journal_title：Planta medica

authors： Yeh SH,Chang FR,Wu YC,Yang YL,Zhuo SK,Hwang TL

更新日期：2005-10-01 00:00:00

abstract：:Two new sesquiterpenes, (E)-(2S,3S,6R)-atlantone-2,3-diol (1) and (E)-(2S,3S,6S)-atlantone-2,3,6-triol (2), along with two known sesquiterpenes, atlantolone (3) and (E)-α-atlantone (4), were isolated from Cedrus deodara Loud. The structures of the new compounds were elucidated on the basis of UV, IR, NMR, HR‑ESI-QTOF‑...

journal_title：Planta medica

authors： Chaudhary A,Sood S,Kaur P,Kumar N,Thakur A,Gulati A,Singh B

更新日期：2012-01-01 00:00:00