Berberine inhibits cell growth and mediates caspase-independent cell death in human pancreatic cancer cells.

abstract：:The present study aimed to investigate standardized ethanol extracts of fruit and leaves of Piper sarmentosum for their in vivo antioxidant activity in rats using a CCl (4)-induced oxidative stress model. The standardization was based on the quantification of the markers pellitorine, sarmentine and sarmentosine by hig...

journal_title：Planta medica

authors： Hussain K,Ismail Z,Sadikun A,Ibrahim P

更新日期：2010-03-01 00:00:00

abstract：:A cell-based method for screening drug candidates from herbal extracts that have possible anti-type II diabetic effects was established. The differentiation of preadipocytes into adipocytes was used as a sensitive primary indicator of a drug's potential effect on type II diabetes. We established a quantitative method ...

journal_title：Planta medica

authors： Xu ME,Xiao SZ,Sun YH,Ou-yang Y,Guan C,Zheng XX

更新日期：2006-01-01 00:00:00

abstract：:Three new glycosides, 1,4,8-trihydroxynaphthalene-1-O-D-glucopyranosyl-(1-->6)-beta-D- xylopyranoside (1), 1,4,8-trihydroxynaphthalene-1-O-beta-D-glucopyranosyl-(1-->6)-alph a-L- arabinopyranoside (2), 1-hydroxy-4-methoxynaphthalene-1-O-beta-D-glucopyranosyl-(1-->6)- alpha-L-rhamnopyranoside (3), were isolated from th...

journal_title：Planta medica

authors： Lee SW,Lee KS,Son JK

更新日期：2000-03-01 00:00:00

abstract：:We have examined the immunosuppressive effects of representative ginsenosides (Rb1, Rb2, Re and Rg1) from Panax ginseng C. A. Meyer on CD4+ and CD8+ lymphocyte proliferation. Ginsenosides differentially modulated lymphocyte proliferation induced by concanavalin A (Con A), lipopolysaccharide (LPS), phytohemaglutinin (P...

journal_title：Planta medica

authors： Cho JY,Kim AR,Yoo ES,Baik KU,Park MH

更新日期：2002-06-01 00:00:00

abstract：:Electrospray ionization mass spectrometry (ESI-MS) combined with multiple tandem mass spectrometry (MS (n)) has been applied for simultaneously determining lipo-alkaloids from the aconite tubers. ESI-MS can give a very good mass separation for lipo-alkaloid mixture and MS (n) can provide structural information. Accord...

journal_title：Planta medica

authors： Sun W,Song F,Cui M,Liu S

更新日期：1999-06-01 00:00:00

abstract：:Two new protopine-type alkaloids, argemexicaine A (1) and argemexicaine B (2), along with thirteen known alkaloids, were isolated from MeOH extracts of Formosan Argemone mexicana L. (Papaveraceae). Physical and spectral analyses, particularly IR and thermo-modulated 1D and 2D NMR, were used to determine the transannul...

journal_title：Planta medica

authors： Chang YC,Hsieh PW,Chang FR,Wu RR,Liaw CC,Lee KH,Wu YC

更新日期：2003-02-01 00:00:00

abstract：:Crocin is a pharmacologically active component of Crocus sativus. It is an unusual water-soluble carotenoid responsible for the red color of saffron. In various studies, the anticancer effect of saffron and its constituents has been established. Polyethylene glycolated nanoliposomes with a size range up to 200 nm are ...

journal_title：Planta medica

authors： Rastgoo M,Hosseinzadeh H,Alavizadeh H,Abbasi A,Ayati Z,Jaafari MR

更新日期：2013-04-01 00:00:00

abstract：:According to traditional usage, the extract of Longan Arillus was tested for its anxiolytic-like effect by application of the Vogel-type anti-conflict method in mice. The extract indicated significant activity at a dose of 2 g/kg, s.c., and results of the bioassay-oriented isolation revealed adenosine to be the active...

journal_title：Planta medica

authors： Okuyama E,Ebihara H,Takeuchi H,Yamazaki M

更新日期：1999-03-01 00:00:00

abstract：:Phytochemical studies on Galanthus species resulted in the isolation of three new compounds: 3,3'-O-(3',3''-dihydroxybutanoyl)hamayne and 11,3'-O-(3',3''-dihydroxybutanoyl)hamayne from G. nivalis and 2-O-(3'-hydroxybutanoyl)lycorine from G. elwesii. Additionally, 3,11-O-(3',3''-dihydroxybutanoyl)hamayne, 3,11,3'-O-(3'...

journal_title：Planta medica

authors： Berkov S,Cuadrado M,Osorio E,Viladomat F,Codina C,Bastida J

更新日期：2009-10-01 00:00:00

abstract：:In our ongoing research into anti-inflammatory compounds from Tanacetum microphyllum, four naturally occurring flavonoids (santin, ermanin, centaureidin and 5,3'-dihydroxy-4'-methoxy-7-methoxycarbonylflavonol) and one sesquiterpene lactone (hydroxyachillin) isolated from this plant, were evaluated as potential inhibit...

journal_title：Planta medica

authors： Abad MJ,Bermejo P,Alvarez M,Guerra JA,Silván AM,Villar AM

更新日期：2004-01-01 00:00:00

abstract：:Bioassay-guided fractionation of the hexanic root bark extract of Casearia sylvestris var. lingua led to the isolation of a new clerodane diterpene, whose structure was elucidated as rel-(2 S,5 R,6 R,8 S,9 S,10 R,18 S,19 R)-19-acetoxy-18,19-epoxy-6-hydroxy-18-butanoyloxy-2-(2-methylbutanoyloxy)cleroda-3,13(16), 14-tri...

journal_title：Planta medica

authors： Espindola LS,Vasconcelos Júnior JR,de Mesquita ML,Marquié P,de Paula JE,Mambu L,Santana JM

更新日期：2004-11-01 00:00:00

abstract：:The effect of extracts of MOMORDICA CHARANTIA L. fruits on glucose metabolism and glucose uptake was investigated. The fruit of momordica, at all ripening stages, was found to contain two inhibitory compounds: one against hexokinase activity and the other against glucose uptake by rat intestinal fragments. Both inhibi...

journal_title：Planta medica

authors： Meir P,Yaniv Z

更新日期：1985-02-01 00:00:00

abstract：:Three new azaphilones, chaetomugilin S (1), 7,5'-bis-epi-chaetoviridin A (2), and 7-epi-chaetoviridin E (3), and two new chlorinated phenolic glycosides, globosumoside A (4) and globosumoside B (5), were isolated from the crude extract of the fungal strain Chaetomium elatum No. 89-1-3-1. Their structures were determin...

journal_title：Planta medica

authors： Chen GD,Li YJ,Gao H,Chen Y,Li XX,Li J,Guo LD,Cen YZ,Yao XS

更新日期：2012-10-01 00:00:00

abstract：:Five new compounds, including one new xanthone, 1-hydroxy-5-methoxyxanthone 6-O-β-D-glucopyranoside (1), one new lignan, 3-(β-D-glucopyranosyloxymethyl)-2-(4-hydroxy-3-methoxyphenyl)-5-(3-acetoxypropyl)-7-methoxy-(2R,3S)-dihydrobenzofuran (2), and three new γ-pyrones, japonicumone A 4'-O-β-D-glucopyranoside (3), japon...

journal_title：Planta medica

authors： Zhou GS,Ma XL,Zeng KW,Tu PF,Jiang Y

更新日期：2013-05-01 00:00:00

abstract：:Three new vermistatin derivatives, 6-demethylpenisimplicissin (1), 5'-hydroxypenisimplicissin (2), and 2''-epihydroxydihydrovermistatin (3), along with five known vermistatin analogues, methoxyvermistatin (4), vermistatin (5), 6-demethylvermistatin (6), hydroxyvermistatin (7), and penisimplicissin (8), were isolated f...

journal_title：Planta medica

authors： Liu Y,Xia G,Li H,Ma L,Ding B,Lu Y,He L,Xia X,She Z

更新日期：2014-07-01 00:00:00

abstract：:The olive (Olea europaea) leaf is considered an important traditional herbal medicine utilized against infectious diseases, and for the treatment of diabetes and hypertension. Moreover, olive leaf constituents have been related to cardioprotection, probably due to their association with cellular redox modulating effec...

journal_title：Planta medica

authors： Efentakis P,Iliodromitis EK,Mikros E,Papachristodoulou A,Dagres N,Skaltsounis AL,Andreadou I

更新日期：2015-06-01 00:00:00

abstract：:Two triterpenoidal saponins having phytolaccagenin as the aglycone were isolated from the roots of Phytolacca esculenta (Phytolaccaceae). The structures of two new saponins, esculentoside I and esculentoside N, were established to be 3-O-[beta-D-glucopyranosyl-(1----4)-beta-D- glucopyranosyl]-28-O-beta-D-glucopyranosy...

journal_title：Planta medica

authors： Yi YH

更新日期：1992-02-01 00:00:00

abstract：:High molecular compounds from Chinese herbal medicines, including ribosome-inactivating proteins and polysaccharides from both fungi and high plants have been tested for the treatment of malignant diseases. Polysaccharides possessing immunostimulating activities can be used as adjuvants in tumor treatment. The fungi c...

journal_title：Planta medica

authors： Tang W,Hemm I,Bertram B

更新日期：2003-03-01 00:00:00

abstract：:Ganoderma is a genus of medicinal mushroom traditionally used for treating various diseases. Ganoderic acid A is one of the major bioactive Ganoderma triterpenoids isolated from Ganoderma species. Herein, we produced a highly specific monoclonal antibody against ganoderic acid A (MAb 12 A) and developed an indirect co...

journal_title：Planta medica

authors： Sakamoto S,Kohno T,Shimizu K,Tanaka H,Morimoto S

更新日期：2016-05-01 00:00:00

abstract：:The ethanolic extract of Ilex aquifolium L. (Aquifoliaceae) concentration-dependently inhibited leukotriene B4 biosynthesis in isolated bovine PMNL with an IC50 value of about 60 micrograms/ml, whereas the effect on epidermal 12(S)-HETE biosynthesis was much less pronounced. The extract also inhibited the non-enzymati...

journal_title：Planta medica

authors： Müller K,Ziereis K,Paper DH

更新日期：1998-08-01 00:00:00

abstract：:Halimium halimifolium (Hh) is a shrub used in Algerian folk medicine to treat gastrointestinal pain. An UHPLC-PDA-ESI/MSn method was developed to identify the metabolic profile of the traditionally used infusion (Hh-A) from the aerial parts. The structures of flavanols were confirmed by NMR analysis after the isolatio...

journal_title：Planta medica

authors： Kerbab K,Sansone F,Zaiter L,Esposito T,Celano R,Franceschelli S,Pecoraro M,Benayache F,Rastrelli L,Picerno P,Aquino RP,Mencherini T

更新日期：2019-08-01 00:00:00

abstract：:Purification of a cytotoxic crude alkaloid extract of Cassytha filiformis led to the isolation of four known aporphine alkaloids: neolitsine, dicentrine, cassythine (= cassyfiline) and actinodaphnine. Their structures were determined by analysis of spectroscopic data. All isolated alkaloids were tested for their cytot...

journal_title：Planta medica

authors： Stévigny C,Block S,De Pauw-Gillet MC,de Hoffmann E,Llabrès G,Adjakidjé V,Quetin-Leclercq J

更新日期：2002-11-01 00:00:00

abstract：:Ischemic preconditioning, which is mediated by cell signaling molecules, protects the heart from ischemia-reperfusion injury by limiting the infarct size. Oleuropein, the main polyphenolic constituent of olives, reduced the infarct size in normal and cholesterol-fed rabbits when it was administered at a nutritional do...

journal_title：Planta medica

authors： Andreadou I,Benaki D,Efentakis P,Bibli SI,Milioni AI,Papachristodoulou A,Zoga A,Skaltsounis AL,Mikros E,Iliodromitis EK

更新日期：2015-06-01 00:00:00

abstract：:The high number of citations of the previous review on anti-HIV compounds from plants published in 1998 in Planta Medica indicates the importance of natural products research in the battle against HIV. Therefore, we have decided to write an update of our previous review paper, this time covering the time span 1998 - 2...

journal_title：Planta medica

authors： Cos P,Maes L,Vlietinck A,Pieters L

更新日期：2008-09-01 00:00:00

abstract：:An ionpair-HPLC-technic using a reversed-phase column was developed to screen plant extracts for cardiotonic amines and to isolate them in a preparative scale for direct MS and pharmacological investigations. By this method the positive inotropic tyramine could be isolated from Selenicereus grandiflorus (L.) Britt et ...

journal_title：Planta medica

authors： Wagner H,Grevel J

更新日期：1982-01-01 00:00:00

abstract：:Eleven sesquiterpenoids have been isolated from the whole plants of Youngia japonica (Asteraceae). Among these sesquiterpenoids, five were identified as new compounds on the basis of spectroscopic methods and chemical analysis. Their structures were 3-oxo-8alpha-(4-hydoxyphenyl)acetoxy-10(14),11(13)-guaiadien-12,6-oli...

journal_title：Planta medica

authors： Chen W,Liu Q,Wang J,Zou J,Meng D,Zuo J,Zhu X,Zhao W

更新日期：2006-02-01 00:00:00

abstract：:Catharanthus roseus cell suspension cultures were employed for the biotransformation of 2alpha,5alpha,10beta,14beta-tetraacetoxy-4(20),11-taxadiene ( 1), and four metabolites were obtained. Based on their physical and chemical data, the structures of the four metabolites were respectively elucidated as 10beta-hydroxy-...

journal_title：Planta medica

authors： Dai J,Cui Y,Zhu W,Guo H,Ye M,Hu Q,Zhang D,Zheng J,Guo D

更新日期：2002-12-01 00:00:00

abstract：:Chromatographically purified fractions of aqueous-ethanolic extracts from Baptisia tinctoria roots contained a strong lymphocyte DNA synthesis-stimulating activity. Electrophoretic analysis of these fractions revealed four distinct protein bands with molecular masses of P1 = 58 kD; P4 = 31 kD; P5 = 26 kD; and P6 = 14 ...

journal_title：Planta medica

authors： Beuscher N,Scheit KH,Bodinet C,Kopanski L

更新日期：1989-08-01 00:00:00

abstract：:A new cytotoxic cyclopenta[b]benzofuran derivative, aglaiformosanin (1) and three known cyclopenta[b]benzofuran derivatives (2 - 4) were isolated from the stem bark of Aglaia formosana. Compounds 1 - 4 exhibited potent cytotoxicity against the P-388, KB, HT-29, HL-60, and A549 cell lines. The structure of compound 1 w...

journal_title：Planta medica

authors： Wang SK,Duh CY

更新日期：2001-08-01 00:00:00

abstract：:Stem extracts of Styrax camporum Pohl and Caesalpinia ferrea Martius were administered orally and intraperitoneally to rats and effected a decrease in the acute ulceration number. The volume, pH, and hydrochloric acid concentration of gastric secretions were measured after administration of both extracts, atropine, an...

journal_title：Planta medica

authors： Bacchi EM,Sertié JA

更新日期：1994-04-01 00:00:00