Abstract:
:25 Amaryllidaceae alkaloids belonging to different skeletal types were evaluated for their cytotoxic activity against one murine non-tumoral cell line (LMTK) and two human tumoral cell lines (Molt4 and HepG2) according to established protocols. Significant differences of activity related with the type of skeleton of the tested alkaloids could be observed. Pretazettine (22) was among the most active compound among the 25 tested alkaloids on the Molt4 lymphoid cells, but was inactive against HepG2 hepatoma. On the other hand, lycorenine (11) was found to be the most cytotoxic compound against HepG2 hepatoma, even though it appears to be active against Molt4 cells. Almost all of the tested alkaloids showed cytotoxic activity against fibroblastic LMTK cells. Only mesembrenone (25) showed some specificity against Molt4 cells in comparison to LMTK cells.
journal_name
Planta Medjournal_title
Planta medicaauthors
Weniger B,Italiano L,Beck JP,Bastida J,Bergoñon S,Codina C,Lobstein A,Anton Rdoi
10.1055/s-2006-958007subject
Has Abstractpub_date
1995-02-01 00:00:00pages
77-9issue
1eissn
0032-0943issn
1439-0221journal_volume
61pub_type
信件相关文献
PLANTA MEDICA文献大全abstract::A contribution of the volatile oil from ginger rhizomes (Zingiber officinale Roscoe) on inhabiting the 5-HT3 receptor complex had been shown. In the present study a possible interaction of some compounds of the volatile oil with the 5-HT3 receptor system expressed in N1E-115 cells and with the serotoninergic system of...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-967171
更新日期:2007-04-01 00:00:00
abstract::Thyme extract is known to posses spasmolytic effects on isolated trachea and to increase ciliary activity. A small part of this effect is mediated via beta (2) receptors, but other receptors are supposed to be involved. Endothelin has a pathophysiological impact in asthma with respect to hyper-reagibility and contract...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2008-1081349
更新日期:2008-10-01 00:00:00
abstract::From roots of Rubia cordifolia L. four anthraquinones are isolated: 1-hydroxy 2-methoxy anthraquinone; 1,4-dihydroxy 2-methyl 5-methoxy anthraquinone or 1,4-dihydroxy 2-methyl 8-methoxy anthraquinone; 1,3-dimethoxy 2-carboxy anthraquinone and rubiadin. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-971524
更新日期:1981-12-01 00:00:00
abstract::The olive (Olea europaea) leaf is considered an important traditional herbal medicine utilized against infectious diseases, and for the treatment of diabetes and hypertension. Moreover, olive leaf constituents have been related to cardioprotection, probably due to their association with cellular redox modulating effec...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-0035-1546017
更新日期:2015-06-01 00:00:00
abstract::We identified eight diterpenes from Cryptomeria japonica (Taxodiaceae), which inhibit the activity of the androgen receptor (AR) in human prostate cancer (PCa) 22Rv1-derived 103E cells. The compounds 6,12-dihydroxyabieta-5,8,11,13-tetraen-7-one ( 2), sugiol ( 3), ferruginol ( 4), and 5-epixanthoperol ( 7) have near 10...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-990233
更新日期:2007-10-01 00:00:00
abstract::Effects of puerarin, an active principle contained in the roots of Pueraria lobata (Leguminosae), on the regulation of glucose metabolism in an insulin deficient state were investigated in cultured myoblast C 2 C 12 cells using glucose uptake as indicator. Puerarin enhanced the uptake of radioactive glucose into C 2 C...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2002-35656
更新日期:2002-11-01 00:00:00
abstract::The neuroprotective effects of spiramine T, an atisine-type diterpenoid alkaloid isolated from the Chinese herbal medicine Spiraea japonica var. acuta (Rosaceaee), on cerebral ischemia-reperfusion injury produced by 10-min bilateral occlusion of the common carotid arteries followed by 5-day reperfusion in gerbils were...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2001-11510
更新日期:2001-03-01 00:00:00
abstract::Gas chromatography-flame ionization detection (GC-FID) was used to assess the chemical profile and quantification of cannabinoids to identify the differences, if existing, in the chemical constituents of in vitro propagated plants (IVP), conventionally grown plants (VP) and indoor grown mother plants (MP-Indoor) of a ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0029-1240628
更新日期:2010-05-01 00:00:00
abstract::A gas-chromatographical method is described on which seven pyrrolizidine alkaloids (Fuchsisenecionine, Senecionine, Senecivernine, Senkirkine, Retrorsine, O (7)-Angelylheliotridine and Heliotrine) are determinated in a qualitative way and their ratio of concentration in Senecio fuchsii, vernalis, inaequidens and ovire...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-971688
更新日期:1981-02-01 00:00:00
abstract::The aim of the present study was to investigate the antistress potential of LABISIA PUMILA aqueous extract (LPPM/A003) using a battery of tests widely employed in different stressful situations. Pretreatment of experimental animals with LPPM/A003 caused an increase in the swimming endurance and hypoxia time and also s...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0029-1240953
更新日期:2010-10-01 00:00:00
abstract::In the extremely skin irritant and caustic latex of Excoecaria agallocha the major part of the polyfunctional diterpene esters (DTE) (group I) are aliphatic polyunsaturated 9,13,14-orthoesters of the daphnane-type parent alcohol 5 beta-hydroxyresiniferonol-6 alpha, 7 alpha-epoxide, esterified simultaneously in their 2...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-959499
更新日期:1994-08-01 00:00:00
abstract::Continued examination of the stem bark of Newbouldia laevis afforded three minor phenylethanoid glycosides, designated as newbouldiosides D - F. Their structures were elucidated by spectroscopic methods as β-(3,4-dihydroxyphenyl)ethyl 5-O-syringoyl-β-D-apiofuranosyloxy-(1 → 2)-O-[α-L-rhamnopyranosyl-(1 → 3)]-6-O-E-sin...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/a-1270-7761
更新日期:2020-11-06 00:00:00
abstract::Olive oil has been shown to exhibit beneficial effects in the prevention of cardiovascular diseases although its molecular mechanism still remains unclear. In the present study, we investigated the effect of hydroxytyrosol (HT), a major phenolic component in olive oil and leaves from OLEA EUROPAEA L. (Oleaceae family...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0030-1271073
更新日期:2011-10-01 00:00:00
abstract::The cytotoxicity of goniothalamin was found to be strong towards both cancerous (HGC-27, MCF-7, PANC-1, HeLa), and non-cancerous (3T3) cell lines, especially in cases of dividing cells. Drug exposure studies indicated that the cytotoxic action of goniothalamin was time- and dose-dependent. At the ultrastructural level...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-957611
更新日期:1997-02-01 00:00:00
abstract::The dietary intake of flavonoids seems to be inversely related to cardiovascular mortality. The consumption of isoflavonoids is increasing in the general population, especially due to the use of food supplements and a variety of isoflavonoid-rich foods. However, detailed studies on the vascular influence of individual...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/a-1158-9422
更新日期:2020-07-01 00:00:00
abstract::In our ongoing research into anti-inflammatory compounds from Tanacetum microphyllum, four naturally occurring flavonoids (santin, ermanin, centaureidin and 5,3'-dihydroxy-4'-methoxy-7-methoxycarbonylflavonol) and one sesquiterpene lactone (hydroxyachillin) isolated from this plant, were evaluated as potential inhibit...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2004-815452
更新日期:2004-01-01 00:00:00
abstract::There is an obvious discrepancy between the popularity of mistletoe extracts and their classification as a non-conventional treatment modality with unproven efficacy in oncology. The commercial preparations suffer from several major drawbacks: lack of precise declarations for the molecular characteristics and the conc...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-2006-959396
更新日期:1994-02-01 00:00:00
abstract::Fractionation of the aqueous extract of Derris scandens stems extract using tests for eicosanoid inhibition resulted in the isolation of three isoflavonoids, genistein, its 7- O-alpha-rhamno(1-->6)-beta-glucosyl glycoside, a new compound, and two known isoprenyl derivatives 3'-gamma,gamma-dimethylallylweighteone and s...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2004-827147
更新日期:2004-06-01 00:00:00
abstract::YANG XIN is a traditional Chinese medicine formulation used for nervous fatigue and consists of a proprietary blend of concentrated extracts from 18 plant ingredients. The 18 constituent plant ingredients, YANG XIN capsules, and formulations 2014-005_1 A and 1B were extracted by consecutive 24-hour macerations with di...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-106170
更新日期:2016-08-01 00:00:00
abstract::This review describes the current status of the development of techniques combining liquid chromatography and nuclear magnetic resonance and their use in the context of natural products. HPLC-NMR methods have a rapidly growing impact on natural products research by enabling structure determination of natural products ...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-2005-871298
更新日期:2005-08-01 00:00:00
abstract::Geniposide, a main iridoid glucoside component of gardenia fruit, has been shown to possess anti-inflammatory activity. However, its potential use for acute lung injury (ALI) has not yet been studied. The aim of this study was to evaluate the anti-inflammatory properties of geniposide using a mouse ALI model. ALI was ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1298212
更新日期:2012-04-01 00:00:00
abstract::Ginkgetin, a biflavone isolated from Ginkgo biloba leaves, was previously reported as an inhibitor of group II phospholipase A2. In this study, ginkgetin was evaluated for in vivo antiarthritic and analgesic activities. Ginkgetin (10-20 mg/kg/day) strongly reduced arthritic inflammation in an animal model of rat adjuv...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-960815
更新日期:1999-06-01 00:00:00
abstract::Qianhu, the dried roots of Peucedanum praeruptorum, is a well-known traditional Chinese medicinal herb which was officially listed in the Chinese Pharmacopoeia. Praeruptorin A is the major active constituent of Qianhu. Our previous studies show that praeruptorin effectively transactivated the protein expression and ca...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0033-1350795
更新日期:2013-11-01 00:00:00
abstract::In our ongoing efforts to identify effective naturally sourced agents for the treating of diabetic complications, two new (1 and 2) and 11 known phenolic compounds (3-13) were isolated from an 80 % ethanol extract of Litsea japonica leaves. The structures of the new compounds were established by spectroscopic and chem...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-116324
更新日期:2017-02-01 00:00:00
abstract::A new tetrahydrofuran lignan, named henricine ( 1), was isolated from the stems of SCHISANDRA HENRYI. High resolution COSY spectrum was used in the structural elucidation. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969265
更新日期:1986-12-01 00:00:00
abstract::Natural products can exhibit many beneficial effects on human health. As far as cancer is concerned, naturally occurring compounds have been reported to prevent tumorigenesis and also to suppress the growth of established tumors. As cancer cells have evolved multiple mechanisms to resist the induction of programmed ce...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-0030-1249961
更新日期:2010-08-01 00:00:00
abstract::The aim of this study was to determine the molecular mechanism underlying the inhibition of vascular restenosis by Radix Sophorae Flavescentis (RSF) extract after balloon dilatation injury. In a rat carotid model of balloon dilatation injury, the RSF extract showed a significant inhibitory effect on vascular restenosi...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0029-1185602
更新日期:2009-10-01 00:00:00
abstract::HPLC determinations of the aescin contents in calli and embryoids from leaf explants of AESCULUS HIPPOCASTANUM L. were carried out in order to determine whether it was possible to obtain aescin-forming proliferations IN VITRO. The results indicate that embryogenic calli and embryoids derived from them produce an amoun...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-960016
更新日期:1991-02-01 00:00:00
abstract::Products of lipoxygenase metabolism play a role in the pathogenesis of psoriasis. Four protoberberine alkaloids, berberine, oxyberberine, jatrorrhizine, columbamine, and two aporphine alkaloids, magnoflorine, and corytuberine, isolated from Mahonia aquifolium, were tested for lipoxygenase inhibition. Oxyberberine, cor...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-958107
更新日期:1995-08-01 00:00:00
abstract::Since the beginning of this century, Goji berries and juice are being sold as health food products in western countries and praised in advertisements and in the media for well-being and as an anti-aging remedy. The popularity of Goji products has rapidly grown over the last years thanks to efficient marketing strategi...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-0029-1186218
更新日期:2010-01-01 00:00:00