Abstract:
:We identified eight diterpenes from Cryptomeria japonica (Taxodiaceae), which inhibit the activity of the androgen receptor (AR) in human prostate cancer (PCa) 22Rv1-derived 103E cells. The compounds 6,12-dihydroxyabieta-5,8,11,13-tetraen-7-one ( 2), sugiol ( 3), ferruginol ( 4), and 5-epixanthoperol ( 7) have near 100 % AR inhibition efficacy at concentrations of 10, 5, 25, and 25 microM, respectively. Because these compounds have very similar structures, analysis of their differential activity may aid in the design of inhibitors for PCa treatment.
journal_name
Planta Medjournal_title
Planta medicaauthors
Tu WC,Wang SY,Chien SC,Lin FM,Chen LR,Chiu CY,Hsiao PWdoi
10.1055/s-2007-990233subject
Has Abstractpub_date
2007-10-01 00:00:00pages
1407-9issue
13eissn
0032-0943issn
1439-0221journal_volume
73pub_type
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