Abstract:
:Gleditsioside E, a triterpene saponin isolated from Gleditsia sinensis, showed significant cytotoxicity against Bel-7402, BGC-823, HeLa, HL-60 and MCF-7 cell lines. The results of flow cytometry with annexin V-FITC/PI double staining proved that gleditsioside E mainly induced early apoptosis in HL-60 cells. Gleditsioside E treatment resulted in a prominent increase of the G 2 /M population in HL-60 cells, and an accumulation of the sub-G 1 (hypoploid) peak was observed.
journal_name
Planta Medjournal_title
Planta medicaauthors
Zhong L,Qu G,Li P,Han J,Guo Ddoi
10.1055/s-2003-40645subject
Has Abstractpub_date
2003-06-01 00:00:00pages
561-3issue
6eissn
0032-0943issn
1439-0221journal_volume
69pub_type
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