Antiedematogenic and free radical scavenging activity of swertiamarin isolated from Enicostemma axillare.


:Swertiamarin, a secoiridoid isolated from the ethyl acetate extract of Enicostemma axillare, was evaluated for antiedematogenic activity using carrageenan-, formalin-, and histamine-induced paw edema methods in rats. In the carrageenan-induced method, the percentages of edema inhibition obtained after 5 h induction were 38.60, 52.50, and 45.44, respectively, for 100 and 200 mg/kg bw swertiamarin and 100 mg/kg bw of standard diclofenac sodium given orally. The activity of swertiamarin at 200 mg/kg bw was found to be superior to that of standard diclofenac sodium in all these methods. Swertiamarin was also screened for IN VITRO antioxidant activity using seven different methods: good activity was observed in ABTS and hydrogen peroxide methods, and moderate activity was observed in hydroxyl radical by deoxyribose and lipid peroxidation methods, with IC50 values of 2.83, 5.70, 52.56, and 78.33 microg/mL, respectively. The total antioxidant capacity was found to be 4.51 mM of ascorbic acid per gram of swertiamarin. Swertiamarin possesses antiedematogenic and in vitro antioxidant activities, and it may be the active constituent responsible for the anti-inflammatory activity of E. AXILLARE.


Planta Med


Planta medica


Vaijanathappa J,Badami S




Has Abstract


2009-01-01 00:00:00












  • Immunoassays for the quantitative determination of colchicine.

    abstract::A radioimmunoassay as well as an enzyme immunoassay for the quantitation of fmol amounts of the alkaloid colchicine have been developed. The antiserum used for both assays was raised against a conjugate of colchicoside-bovine serum albumin. The crude serum was satisfactory for the performance of the radioimmunoassay. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Poulev A,Deus-Neumann B,Bombardelli E,Zenk MH

    更新日期:1994-02-01 00:00:00

  • Antimicrobial hasubanalactam alkaloid from Stephania glabra.

    abstract::A novel hasubanalactam alkaloid, named glabradine, has been isolated from the tubers of Stephania glabra, together with three known quaternary protoberberine alkaloids, palmatine, dehydrocorydalmine and stepharanine. The structure of glabradine was assigned as 7-O-demethyl-N,O-dimethyloxostephinine, by means of rigoro...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Semwal DK,Rawat U

    更新日期:2009-03-01 00:00:00

  • HPTLC method for the estimation of alkaloids of Cinchona officinalis stem bark and its marketed formulations.

    abstract::We report a sensitive method for the estimation of quinine (Qn), cinchonine (Cn), and cinchonidine (Cnd) and a new method based on fluorescence enhancement and detection and quantification of quinidine (Qnd) from Cinchona stem bark and its formulations, using HPTLC. Standard solutions of Qn, Qnd, Cn, and Cnd were appl...

    journal_title:Planta medica

    pub_type: 信件


    authors: Ravishankara MN,Shrivastava N,Padh H,Rajani M

    更新日期:2001-04-01 00:00:00

  • Quality control of herbal material and phytopharmaceuticals with MS and NMR based metabolic fingerprinting.

    abstract::Metabolic fingerprinting techniques have received a lot of attention in recent years and the annual amount of publications in this field has increased significantly over the past decade. This increase in publications is due to improvements in the analytical performance, most notably in the field of NMR and MS analysis...

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    pub_type: 杂志文章,评审


    authors: van der Kooy F,Maltese F,Choi YH,Kim HK,Verpoorte R

    更新日期:2009-06-01 00:00:00

  • Isoflavonoids from Pueraria mirifica and their estrogenic activity.

    abstract::Nine isoflavonoids including a new pterocarpene, puemiricarpene, were isolated from the tuberous root of Pueraria mirifica (Leguminosae). The structure of puemiricarpene was determined by spectroscopic means. Estrogenic activity of the isolated isoflavonoids was tested using MCF-7 human breast cancer cells. Moderate a...

    journal_title:Planta medica

    pub_type: 信件


    authors: Chansakaow S,Ishikawa T,Sekine K,Okada M,Higuchi Y,Kudo M,Chaichantipyuth C

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  • Antiplasmodial alkaloids from the stem bark of Strychnos malacoclados.

    abstract::From the stem bark of Strychnos malacoclados, one new bisindole alkaloid, 3-hydroxylongicaudatine Y (1), was isolated along with the known alkaloids vomicine (2), bisnordihydrotoxiferine (3), divarine (4), longicaudatine (5), longicaudatine Y (6), and longicaudatine F (7). All the compounds were tested for their antim...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Tchinda AT,Ngono AR,Tamze V,Jonville MC,Cao M,Angenot L,Frédérich M

    更新日期:2012-03-01 00:00:00

  • Arbuscular mycorrhizal inoculation enhances survival rates and growth of Micropropagated plantlets of Echinacea pallida.

    abstract::In an attempt to induce positive effects on the acclimatization of in vitro propagated Echinacea pallida, four arbuscular mycorrhizal (AM) fungi, Glomus mosseae, Gigaspora ramisporophora, Scutellospora fulgida and Entrophospora colombiana were selected to aid the soil adaptation process. Fungal inocula affected the su...

    journal_title:Planta medica

    pub_type: 信件


    authors: Lata H,De Andrade Z,Schaneberg B,Bedir E,Khan I,Moraes R

    更新日期:2003-07-01 00:00:00

  • Prevention of hydrogen peroxide damage by soybean saponins to mouse fibroblasts.

    abstract::Soybean saponin is one of several soybean glycosides. Recently, new soybean saponins which possess the DDMP (2,5-dihydroxy-6-methyl-2,3-dihydro-4H-pyran-4-one) moiety have been detected. Soyasaponin beta g of these new soybean saponins was shown to inhibit hydrogen peroxide damage to mouse fibroblast cells. Not only t...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Yoshikoshi M,Yoshiki Y,Okubo K,Seto J,Sasaki Y

    更新日期:1996-06-01 00:00:00

  • Four new lignans from the stems of Kadsura heteroclita.

    abstract::Two new C(18) dibenzocyclooctadiene lignans named heteroclitalignans A and B (1 and 3), one new C(19) homolignan named heteroclitalignan C(4) and one new natural product named heteroclitalignan D(2), together with the four known lignans kadsurarin (5), kadsulignan E (6), d-epigalbacin, and meso-dihydroguaiaretic acid ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Wang W,Liu J,Liu R,Xu Z,Yang M,Wang W,Liu P,Sabia G,Wang X,Guo D

    更新日期:2006-02-01 00:00:00

  • New antioxidant and antimicrobial ellagic acid derivatives from Pteleopsis hylodendron.

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    pub_type: 杂志文章


    authors: Atta-Ur-Rahman,Ngounou FN,Choudhary MI,Malik S,Makhmoor T,Nur-E-Alam M,Zareen S,Lontsi D,Ayafor JF,Sondengam BL

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  • Two New Anthraquinones from the Seeds of Peganum harmala.

    abstract::Two new anthraquinones have been isolated from the seeds of PEGANUM HARMALA Linn and the structures established as 3,6-dihydroxy-8-methoxy-2-methylanthraquinone (peganone; 1) and 8-hydroxy-7-methoxy-2-methylanthraquinone (peganone; 2) by spectral correlations and chemical evidences. ...

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    pub_type: 杂志文章


    authors: Pitre S,Srivastava SK

    更新日期:1987-02-01 00:00:00

  • High performance liquid chromatography in phytochemical analysis of Eurycoma longifolia.

    abstract::An analytical method using HPLC with UV detection was developed to investigate the quassinoid content of Eurycoma longifolia Jack (Simaroubaceae) collected from various sources. Eurycomanone (1), longilactone (2), 14,15beta-dihydroxyklaineanone (3), 15beta-acetyl-14-hydroxyklaineanone (4), 6alpha-hydroxyeurycomalacton...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Chan KL,Choo CY,Morita H,Itokawa H

    更新日期:1998-12-01 00:00:00

  • Nematicidal activities of two phytoalexins from Taverniera abyssinica.

    abstract::The traditional analgesic and antipyretic Ethiopian drug "Dingetegna" is made of dried root material of Taverniera abyssinica A. Rich (Leguminosae). In a screening for nematicidal natural products, "Dingetegna" extracts showed strong nematicidal activities towards C. elegans. In the following, medicarpin and 4-hydroxy...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Stadler M,Dagne E,Anke H

    更新日期:1994-12-01 00:00:00

  • An anti-inflammatory ent-kaurane from the stems of Annona squamosa that inhibits various human neutrophil functions.

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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Yeh SH,Chang FR,Wu YC,Yang YL,Zhuo SK,Hwang TL

    更新日期:2005-10-01 00:00:00

  • New ester alkaloids from lupins (genus lupinus).

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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Mühlbauer P,Witte L,Wink M

    更新日期:1988-06-01 00:00:00

  • Antibacterial activity of calozeyloxanthone isolated from Calophyllum species against vancomycin-resistant Enterococci (VRE) and synergism with antibiotics.

    abstract::Calozeyloxanthone ( 1) was re-isolated from the root bark of Calophyllum moonii, an endemic species of Sri Lanka, and found to be active against vancomycin-resistant Enterococci (VRE) and vancomycin-sensitive Enterococci (VSE) with MIC values of 6.25 microg/ml and 12.5 microg/ml, respectively. Further, a marked synerg...

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    pub_type: 信件


    authors: Sakagami Y,Kajimura K,Wijesinghe WM,Dharmaratne HR

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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Häberlein H,Boonen G,Beck MA

    更新日期:1997-02-01 00:00:00

  • An in vitro Study on the Effect of Momordica charantia on Glucose Uptake and Glucose Metabolism in Rats.

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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Meir P,Yaniv Z

    更新日期:1985-02-01 00:00:00

  • Tetrandrine selectively protects against amyloid-beta protein - but not against MPTP-induced cytotoxicity in SK-N-SH neuroblastoma cells.

    abstract::The evidence for loss of Ca2+ homeostasis due to neuronal degeneration is considerable and rapidly increasing. In this study, we try to evaluate the protective effect of tetrandrine (TET), an alkaloid isolated from the Chinese medicinal herb Radix Stephania tetrandrae S., on amyloid-beta protein (Abeta) and 1-methyl-4...

    journal_title:Planta medica

    pub_type: 杂志文章


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    journal_title:Planta medica

    pub_type: 信件


    authors: Döpke W,Pham LH,Gründemann E,Bartoszek M,Flatau S

    更新日期:1995-12-01 00:00:00

  • Antineoplastic agents. II. Four furostanol glycosides from rhizomes of Dioscorea collettii var. hypoglauca.

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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Hu K,Dong A,Yao X,Kobayashi H,Iwasaki S

    更新日期:1997-04-01 00:00:00

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    pub_type: 杂志文章


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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Reutrakul V,Ningnuek N,Pohmakotr M,Yoosook C,Napaswad C,Kasisit J,Santisuk T,Tuchinda P

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    abstract::The pharmacokinetics of huperzine A in dogs after single intravenous and oral administrations was investigated. Concentrations of huperzine A were determined by a validated liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. Pharmacokinetic parameters were calculated by non-compartmental methods. After s...

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    pub_type: 杂志文章


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  • [On the gas-chromatographical determination of the pyrrolizidine alkaloids of some Senecio-species].

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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Wiedenfeld H,Pastewka U,Stengl P,Röder E

    更新日期:1981-02-01 00:00:00

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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Ma WH,Lu Y,Chen DF

    更新日期:2013-08-01 00:00:00

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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Galvez Peralta J,Zarzuelo A,Busson R,Cobbaert C,de Witte P

    更新日期:1992-04-01 00:00:00

  • Honokiol induces apoptosis via cytochrome c release and caspase activation in activated rat hepatic stellate cells in vitro.

    abstract::The therapeutic goal in liver fibrosis is the reversal of fibrosis and the selective clearance of activated hepatic stellate cells (HSCs) by inducing apoptosis. Over the past several years, we have screened for natural products that mediate apoptosis in activated HSCs. Among the candidate compounds, honokiol, isolated...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Park EJ,Zhao YZ,Kim YH,Lee BH,Sohn DH

    更新日期:2005-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Gu J,Cheng GG,Qian SY,Li Y,Liu YP,Luo XD

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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Wang CZ,Jia ZJ

    更新日期:1997-06-01 00:00:00