Sarothrin from Alkanna orientalis is an antimicrobial agent and efflux pump inhibitor.


:An Alkanna orientalis leaf and flower extract inhibited the growth of Staphylococcus aureus, a pathogen that causes an estimated 478 000 hospitalizations in the US annually. Bioassay-guided fractionation of A. orientalis resulted in isolation of the flavonoid sarothrin (5,7,4'-trihydroxy-3,6,8-trimethoxyflavone), which inhibited the growth of Mycobacterium smegmatis (MIC 75 µM) and S. aureus (MIC > 800 µM), and possessed efflux pump inhibitory activity. This is the first report of antimicrobial or efflux pump inhibitory activity of sarothrin, and of its presence in A. orientalis. Our findings suggest that the effectiveness of A. orientalis extracts is due to a combination of multiple constituents, including sarothrin.


Planta Med


Planta medica


Bame JR,Graf TN,Junio HA,Bussey RO 3rd,Jarmusch SA,El-Elimat T,Falkinham JO 3rd,Oberlies NH,Cech RA,Cech NB




Has Abstract


2013-03-01 00:00:00












  • Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist.

    abstract::Evodiamine, a major alkaloidal principle of Evodia fruits (Evodia rutaecarpa, Rutaceae), showed vanilloid receptor agonistic activities comparable to capsaicin. The Chinese literature refers to Evodia fruits as a "hot nature" herb. In spite of the similarities in the actions of evodiamine and capsaicin in vitro, evodi...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Kobayashi Y,Nakano Y,Kizaki M,Hoshikuma K,Yokoo Y,Kamiya T

    更新日期:2001-10-01 00:00:00

  • Steroidal saponins from Anemarrhena asphodeloides and their effects on superoxide generation.

    abstract::A new steroidal saponin, timosaponin F, along with six known compounds was isolated from the rhizomes of Anemarrhena asphodeloides Bge. On the basis of chemical and spectroscopic evidence, the structure of timosaponin F was elucidated as (5beta, 25 S):-spirostan-3beta,15alpha,23alpha-triol-3-O-beta- glucopyranosyl-(1-...

    journal_title:Planta medica

    pub_type: 信件


    authors: Meng ZY,Zhang JY,Xu SX,Sugahara K

    更新日期:1999-10-01 00:00:00

  • Chemical Varieties of Essential Oils from Elsholtzia polystachya from Two Different Locations in India1.

    abstract::Capillary GC, GC-MS, IR, GC-IR, (1)H- and (13)C-NMR studies of the essential oil from the leaves and cones of ELSHOLTZIA POLYSTACHYA collected from two different locations in India revealed that one oil contained 1,8-cineol (37.3%), the other one perillene (61.2%) as the main constituent. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Mathela CS,Melkani AB,Bisht JC,Pant AK,Bestmann HJ,Erler J,Kobold U,Rauscher J,Vostrowsky O

    更新日期:1992-08-01 00:00:00

  • Bioactivity-guided isolation of cytotoxic sesquiterpenes and flavonoids from Anthemis ruthenica.

    abstract::A new eudesmanolide sesquiterpene, sivasinolide 6-O-angelate (1), was isolated from the aerial parts of Anthemis ruthenica together with the known compounds chrysanin (2), tanacin (3), 3 beta-hydroxycostunolide (4), centauridin (5), and centaureidin (6). The compounds were obtained by means of bioactivity-guided fract...

    journal_title:Planta medica

    pub_type: 信件


    authors: Hajdú Z,Zupkó I,Réthy B,Forgo P,Hohmann J

    更新日期:2010-01-01 00:00:00

  • Vermistatin derivatives with α-glucosidase inhibitory activity from the mangrove endophytic fungus Penicillium sp. HN29-3B1.

    abstract::Three new vermistatin derivatives, 6-demethylpenisimplicissin (1), 5'-hydroxypenisimplicissin (2), and 2''-epihydroxydihydrovermistatin (3), along with five known vermistatin analogues, methoxyvermistatin (4), vermistatin (5), 6-demethylvermistatin (6), hydroxyvermistatin (7), and penisimplicissin (8), were isolated f...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Liu Y,Xia G,Li H,Ma L,Ding B,Lu Y,He L,Xia X,She Z

    更新日期:2014-07-01 00:00:00

  • Telemetry as a tool to measure sedative effects of a valerian root extract and its single constituents in mice.

    abstract::Valeriana officinalis L. is a popular herbal treatment for mild sleep disorders. Clinical and non-clinical studies found contradictory results for valerian extracts and single constituents regarding the influence on sleep parameters. It was the aim of this study to investigate the sedative effects of a valerian root e...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Chow NK,Fretz M,Hamburger M,Butterweck V

    更新日期:2011-05-01 00:00:00

  • Essential oil composition and antimicrobial activity of three Zingiberaceae from S.Tomé e Príncipe.

    abstract::The essential oil composition of three Zingiberaceae widely used as medicinal aromatic plants from S. Tomé and Príncipe: Aframomum danielli (Hook. f.) K. Schum., Curcuma longa L. and Zingiber officinale Rosc. was studied. Two samples of the essential oils from fruit of A. danielli and from rhizomes of the other two sp...

    journal_title:Planta medica

    pub_type: 信件


    authors: Martins AP,Salgueiro L,Gonçalves MJ,da Cunha AP,Vila R,Cañigueral S,Mazzoni V,Tomi F,Casanova J

    更新日期:2001-08-01 00:00:00

  • Antispasmodic effects of myrrh due to calcium antagonistic effects in inflamed rat small intestinal preparations.

    abstract::Myrrh is the oleo-gum resin of mainly Commiphora molmol and as a powdered substance, one compound in the traditional medicinal product Myrrhinil-Intest®, which has been used for the treatment of unspecific, inflammatory intestinal disorders. The aim of the present study was to evaluate the antispasmodic effect of myrr...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Vissiennon C,Goos KH,Goos O,Nieber K

    更新日期:2015-01-01 00:00:00

  • Citral is a new inducer of caspase-3 in tumor cell lines.

    abstract::Citral, 3,7-dimethyl-2,6-octadien-1-al, a key component of the lemon-scented essential oils extracted from several herbal plants such as lemon grass (Cymbopogon citratus), melissa (Melissa officinalis), verbena (Verbena officinalis) is used as a food additive and as a fragrance in cosmetics. In this study, we investig...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Dudai N,Weinstein Y,Krup M,Rabinski T,Ofir R

    更新日期:2005-05-01 00:00:00

  • Old and new natural products as the source of modern antithrombotic drugs.

    abstract::Natural compounds have been the first historical source of antithrombotic compounds (heparin, vitamin K antagonists, streptokinase, urokinase); molecules extracted from plants or animals still provide some of the most original and promising approaches for the discovery of new drugs in this class. In this review, we wi...

    journal_title:Planta medica

    pub_type: 杂志文章,评审


    authors: Beretz A,Cazenave JP

    更新日期:1991-10-01 00:00:00

  • Neurotropic action of the hydroalcoholic extract of Melissa officinalis in the mouse.

    abstract::A lyophilised hydroalcoholic extract of Melissa officinalis L. (Lamiaceae) has been evaluated for behavioral effects in mice. According to the traditional use of M. officinalis, sedative properties have been confirmed for low doses by the decrease of behavioral parameters measured in a non-familiar environment test (s...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Soulimani R,Fleurentin J,Mortier F,Misslin R,Derrieu G,Pelt JM

    更新日期:1991-04-01 00:00:00

  • Antineoplastic agents. II. Four furostanol glycosides from rhizomes of Dioscorea collettii var. hypoglauca.

    abstract::During activity-guided fractionations to screen for antineoplastic agents, further studies by means of preparative HPLC led to the isolation of four known furostanol saponins: protoneodioscin, protodioscin, protoneogracillin, protogracillin, along with their corresponding artifacts: methyl protoneodioscin, methyl prot...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Hu K,Dong A,Yao X,Kobayashi H,Iwasaki S

    更新日期:1997-04-01 00:00:00

  • New tetrahydroprotoberberine N-oxide alkaloids and cytotoxic constituents of Corydalis tashiroi.

    abstract::Three new tetrahydroprotoberberine N-oxide alkaloids, (-)- cis-corydalmine N-oxide, (-)- trans-corydalmine N-oxide, and (-)- trans-isocorypalmine N-oxide, along with three known benzo[ C]phenanthridine alkaloids, norsanguinarine, dihydrosanguinarine, and oxysanguinarine, six known berberine alkaloids, (-)-tetrahydropa...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Chen JJ,Duh CY,Chen IS

    更新日期:1999-10-01 00:00:00

  • Alkaloids and saponins as cytochrome P450 inhibitors from blue cohosh (Caulophyllum thalictroides) in an in vitro assay.

    abstract::Blue cohosh, Caulophyllum thalictroides (L.) Michx. is a popular herb, roots and rhizomes of which have been extensively used for women's health. Alkaloids and saponins are considered to be responsible for its pharmacological effects. In this investigation the methanolic extract of the roots of blue cohosh, the alkalo...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Madgula VL,Ali Z,Smillie T,Khan IA,Walker LA,Khan SI

    更新日期:2009-03-01 00:00:00

  • Studies on the endocrine effects of the contents of Cimicifuga racemosa:.

    abstract::Endocrine activity can be demonstrated for components of the rhizome of CIMICIFUGA RACEMOSA using ovariectomized rats as experimental model. A selective reduction of the serum concentration of the pituitary luteinizing hormone (LH) takes place upon application of an extract. The active principle can be concentrated by...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Jarry H,Harnischfeger G

    更新日期:1985-02-01 00:00:00

  • Strategies for the genetic manipulation of alkaloid-producing pathways in plants.

    abstract::Increasingly, as a result of recent biochemical work, there exists a realistic possibility of taking a molecular genetic approach to the manipulation of alkaloid-producing pathways in plant tissue cultures. In the pathways forming indole alkaloids in CATHARANTHUS ROSEUS, tropane alkaloids in DATURA and HYOSCYAMUS spec...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Robins RJ,Waltons NJ,Hamill JD,Parr AJ,Rhodes MJ

    更新日期:1991-10-01 00:00:00

  • Analgesic and behavioural effects of Morinda citrifolia.

    abstract::The traditional therapeutic indications for the use of Morinda citrifolia L. (Rubiaceae) have been investigated. The lyophilised aqueous extract of roots of M. citrifolia was evaluated for analgesic and behavioural effects in mice. The extract did not exhibit any toxic effects but did show a significant, dose-related,...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Younos C,Rolland A,Fleurentin J,Lanhers MC,Misslin R,Mortier F

    更新日期:1990-10-01 00:00:00

  • Topical application of luteolin inhibits scratching behavior associated with allergic cutaneous reaction in mice.

    abstract::The present study is aimed at evaluating the effects of luteolin on the scratching behavior associated with an allergic cutaneous reaction in mice. Elicitation of passive cutaneous anaphylaxis, and intradermal injections of compound 48/80, histamine or serotonin induced scratching behavior in ICR mice. Models of irrit...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Baolin L,Weiwei W,Ning T

    更新日期:2005-05-01 00:00:00

  • Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages.

    abstract::Nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) are the major mediators produced in activated macrophages which contribute to the circulatory failure associated with septic shock. An activity-guided fractionation of an MeOH extract of stem bark of Magnolia obovata afforded two inhibitors of NO production...

    journal_title:Planta medica

    pub_type: 信件


    authors: Son HJ,Lee HJ,Yun-Choi HS,Ryu JH

    更新日期:2000-06-01 00:00:00

  • Structural Characterization and Anti-complementary Activities of Two Polysaccharides from Houttuynia cordata.

    abstract::In previous studies, crude Houttuynia cordata polysaccharides showed beneficial effects on acute lung injury in vivo, a syndrome in which anti-complementary activities played an important role. Anti-complementary activity-guided fractionation of H. cordata polysaccharides led to the isolation of two highly branched ho...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Lu Y,Zhang JJ,Huo JY,Chen DF

    更新日期:2019-09-01 00:00:00

  • Immunosuppressive lignans isolated from Saururus chinensis.

    abstract::Bioactivity-guided fractionation of Saururus chinensis (Saururaceae) using a lymphoproliferation assay led us to isolate 5 lignans (compounds 1 - 5). Compounds 1 - 5 were identified as sauchinone, (-)-saucerneol, saucerneol C, manassantin A, and manassantin B, respectively, by spectroscopic analyses. The immunosuppres...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Park SY,Lee SH,Choi WH,Koh EM,Seo JH,Ryu SY,Kim YS,Kwon DY,Koh WS

    更新日期:2007-06-01 00:00:00

  • Composition of the essential fruit oil of Vitex agnus-castus.

    abstract::Vitex agnus-castus, the chaste tree, is used against disorders of the female sexual organs and as an anaphrodisiac. Active constituents are not known. In this study the essential oil of the fruits was investigated by GC and GC-MS. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Zwaving JH,Bos R

    更新日期:1996-02-01 00:00:00

  • The sedative effects and mechanism of action of cedrol inhalation with behavioral pharmacological evaluation.

    abstract::It has been reported that cedarwood oil has sedative effects when inhaled. In this study, we evaluated sedative effects of inhaled cedrol, which is a major component of cedarwood oil. Accumulative spontaneous motor activity was significantly decreased in the cedrol-exposed Wistar rats. Similar results were confirmed i...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Kagawa D,Jokura H,Ochiai R,Tokimitsu I,Tsubone H

    更新日期:2003-07-01 00:00:00

  • A beta-Hydroxychalcone from Leptospermum scoparium.

    abstract::A beta-hydroxychalcone 1, so far not reported as a natural compound, was separated from the diethyl ether extract of LEPTOSPERMUM SCOPARIUM (Myrtaceae). Furthermore, three known flavonoids 2-4 were isolated. The (13)C-NMR spectra of 2-4 are reported, since they have as yet not been reported in the literature. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Mayer R

    更新日期:1993-06-01 00:00:00

  • Differentiation of the traditional Chinese medicinal plants Euphorbia humifusa and E. maculata from adulterants by TaqMan real-time polymerase chain reaction.

    abstract::DNA sequence analysis of the rDNA internal transcribed spacer 1 (ITS1) and TaqMan real-time polymerase chain reaction were exploited for their applications in the differentiation of the traditional chinese medicinal plants euphorbia humifusa and e. maculata from three related adulterants e. hypericifolia, E. atoto and...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Xue HG,Wang H,Li DZ,Xue CY,Wang QZ

    更新日期:2008-02-01 00:00:00

  • Nuciferine Relaxes Tracheal Rings via the Blockade of VDLCC and NSCC Channels.

    abstract::This study aimed to elucidate the mechanisms of nuciferine (a main aporphine alkaloid of lotus leaf extract), which can induce relaxation in contracted tracheal rings. Under Ca2+-free and 2 mM Ca2+ conditions, we found that nuciferine had no effect on the resting muscle tone of tracheal rings. In contrast, nuciferine ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Yang X,Yu MF,Lei J,Peng YB,Zhao P,Xue L,Chen W,Ma LQ,Liu QH,Shen J

    更新日期:2018-01-01 00:00:00

  • NIR Spectroscopy of Actaea racemosa L. rhizome - En Route to Fast and Low-Cost Quality Assessment.

    abstract::Rhizomes of Actaea racemosa L. (formerly Cimicifuga racemosa) gained increasing interest as a plant-derived drug due to its hormone-like activity and the absence of estrogenic activity. According to the Current Good Manufacturing Practices guidelines and pharmacopeial standards, quality assessment of herbal starting m...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Bittner M,Krähmer A,Schenk R,Springer A,Gudi G,Melzig MF

    更新日期:2017-08-01 00:00:00

  • Stabilization of growth factors relevant to wound healing by a plant cell wall biomaterial.

    abstract::Stabilization of growth factors in a wound environment is critical to the wound healing process. Here we report on the stabilization of key growth factors by a unique plant cell wall biomaterial. MicroSheets are clear cell wall fragments isolated from the non-living water storage cells in the pulp or inner gel of Aloe...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Ni Y,Turner D,Yates K,Tizard I

    更新日期:2007-10-01 00:00:00

  • A cytotoxic diacetylene from Dendropanax arboreus.

    abstract::The crude ethanol extract from the leaves of Dendropanax arboreus (Araliaceae) from Monteverde, Costa Rica, exhibits cytotoxic activity against Hep-G2, A-431, H-4IIE, and L-1210 tumor cell lines, but is not toxic against normal hepatocytes. The active component has been isolated by activity-directed separation and ide...

    journal_title:Planta medica

    pub_type: 信件


    authors: Setzer WN,Green TJ,Whitaker KW,Moriarity DM,Yancey CA,Lawton RO,Bates RB

    更新日期:1995-10-01 00:00:00

  • Evaluation of the topical anti-inflammatory activity of ginger dry extracts from solutions and plasters.

    abstract::In this study the skin permeation and the topical anti-inflammatory properties of ginger extracts were investigated. A commercial ginger dry extract (DE) and a gingerols-enriched dry extract (EDE) were evaluated for their in vivo topical anti-inflammatory activity by inhibition of Croton oil-induced ear oedema in mice...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Minghetti P,Sosa S,Cilurzo F,Casiraghi A,Alberti E,Tubaro A,Loggia RD,Montanari L

    更新日期:2007-12-01 00:00:00