Abstract:
:An Alkanna orientalis leaf and flower extract inhibited the growth of Staphylococcus aureus, a pathogen that causes an estimated 478 000 hospitalizations in the US annually. Bioassay-guided fractionation of A. orientalis resulted in isolation of the flavonoid sarothrin (5,7,4'-trihydroxy-3,6,8-trimethoxyflavone), which inhibited the growth of Mycobacterium smegmatis (MIC 75 µM) and S. aureus (MIC > 800 µM), and possessed efflux pump inhibitory activity. This is the first report of antimicrobial or efflux pump inhibitory activity of sarothrin, and of its presence in A. orientalis. Our findings suggest that the effectiveness of A. orientalis extracts is due to a combination of multiple constituents, including sarothrin.
journal_name
Planta Medjournal_title
Planta medicaauthors
Bame JR,Graf TN,Junio HA,Bussey RO 3rd,Jarmusch SA,El-Elimat T,Falkinham JO 3rd,Oberlies NH,Cech RA,Cech NBdoi
10.1055/s-0032-1328259subject
Has Abstractpub_date
2013-03-01 00:00:00pages
327-9issue
5eissn
0032-0943issn
1439-0221journal_volume
79pub_type
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